Risk of Melanoma and Other Cancers in Melanoma-Prone Families
We evaluated the risk of developing melanoma over time in members of 23 melanoma-prone families. All 23 families had dysplastic nevi as well as melanoma. Forty-seven melanomas occurred prospectively, all in family members with dysplastic nevi. The prospective melanomas were markedly thinner than the...
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| Veröffentlicht in: | Journal of investigative dermatology 1993-03, Vol.100 (3), p.S350-S355 |
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| container_title | Journal of investigative dermatology |
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| creator | Tucker, Margaret A. Fraser, Mary C. Goldstein, Alisa M. Elder, David E. Guerry, DuPont Organic, Sara M. |
| description | We evaluated the risk of developing melanoma over time in members of 23 melanoma-prone families. All 23 families had dysplastic nevi as well as melanoma. Forty-seven melanomas occurred prospectively, all in family members with dysplastic nevi. The prospective melanomas were markedly thinner than the melanomas diagnosed prior to or at the time of the subject's entry into the study. The cumulative risk of melanoma by age 50 years among people with dysplastic nevi was 48.9±4.2%. Overall, the relative risk of a prospective melanoma among family members with previous melanoma was 229 (95% confidence interval 110–422). The risk varied by time interval and was 362 in the first 5 years, decreasing to 120 after 5 years. The risk of developing melanoma was 85 times increased (95% confidence interval 41–156) in family members with dysplastic nevi and also declined over time in this group. There was no significant excess of cancers other than melanoma. Close surveillance of these high-risk families has led to diagnosis of melanoma at an earlier developmental stage, which should result in a decrease in mortality over time. |
| doi_str_mv | 10.1038/jid.1993.62 |
| format | Article |
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All 23 families had dysplastic nevi as well as melanoma. Forty-seven melanomas occurred prospectively, all in family members with dysplastic nevi. The prospective melanomas were markedly thinner than the melanomas diagnosed prior to or at the time of the subject's entry into the study. The cumulative risk of melanoma by age 50 years among people with dysplastic nevi was 48.9±4.2%. Overall, the relative risk of a prospective melanoma among family members with previous melanoma was 229 (95% confidence interval 110–422). The risk varied by time interval and was 362 in the first 5 years, decreasing to 120 after 5 years. The risk of developing melanoma was 85 times increased (95% confidence interval 41–156) in family members with dysplastic nevi and also declined over time in this group. There was no significant excess of cancers other than melanoma. Close surveillance of these high-risk families has led to diagnosis of melanoma at an earlier developmental stage, which should result in a decrease in mortality over time.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1038/jid.1993.62</identifier><identifier>PMID: 8440923</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Child ; Dermatology ; Disease Susceptibility - complications ; Dysplastic Nevus Syndrome - complications ; Dysplastic Nevus Syndrome - epidemiology ; Dysplastic Nevus Syndrome - pathology ; Family Health ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Medical sciences ; Melanoma - complications ; Melanoma - epidemiology ; Melanoma - genetics ; Melanoma - pathology ; Middle Aged ; Neoplasm Invasiveness ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Journal of investigative dermatology, 1993-03, Vol.100 (3), p.S350-S355</ispartof><rights>1993 The Society for Investigative Dermatology, Inc</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3112-44af80a8956da9e3c972fe1d1bc716f292682f4037efe018cbd62db8d2ec17073</citedby><cites>FETCH-LOGICAL-c3112-44af80a8956da9e3c972fe1d1bc716f292682f4037efe018cbd62db8d2ec17073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4637783$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8440923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tucker, Margaret A.</creatorcontrib><creatorcontrib>Fraser, Mary C.</creatorcontrib><creatorcontrib>Goldstein, Alisa M.</creatorcontrib><creatorcontrib>Elder, David E.</creatorcontrib><creatorcontrib>Guerry, DuPont</creatorcontrib><creatorcontrib>Organic, Sara M.</creatorcontrib><title>Risk of Melanoma and Other Cancers in Melanoma-Prone Families</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>We evaluated the risk of developing melanoma over time in members of 23 melanoma-prone families. All 23 families had dysplastic nevi as well as melanoma. Forty-seven melanomas occurred prospectively, all in family members with dysplastic nevi. The prospective melanomas were markedly thinner than the melanomas diagnosed prior to or at the time of the subject's entry into the study. The cumulative risk of melanoma by age 50 years among people with dysplastic nevi was 48.9±4.2%. Overall, the relative risk of a prospective melanoma among family members with previous melanoma was 229 (95% confidence interval 110–422). The risk varied by time interval and was 362 in the first 5 years, decreasing to 120 after 5 years. The risk of developing melanoma was 85 times increased (95% confidence interval 41–156) in family members with dysplastic nevi and also declined over time in this group. There was no significant excess of cancers other than melanoma. Close surveillance of these high-risk families has led to diagnosis of melanoma at an earlier developmental stage, which should result in a decrease in mortality over time.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Dermatology</subject><subject>Disease Susceptibility - complications</subject><subject>Dysplastic Nevus Syndrome - complications</subject><subject>Dysplastic Nevus Syndrome - epidemiology</subject><subject>Dysplastic Nevus Syndrome - pathology</subject><subject>Family Health</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma - complications</subject><subject>Melanoma - epidemiology</subject><subject>Melanoma - genetics</subject><subject>Melanoma - pathology</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLAzEUhYMoWqsr18IsxI1MzU1mkszChRRfUKmIgruQSW4wOg9NWsF_75SWrlzdxfk45_IRcgJ0ApSry4_gJlBVfCLYDhlByXgOspC7ZEQpYzmj7O2AHKb0QSmIolT7ZF8VBa0YH5Gr55A-s95nj9iYrm9NZjqXzRfvGLOp6SzGlIVum-ZPse8wuzVtaAKmI7LnTZPweHPH5PX25mV6n8_mdw_T61luOQDLi8J4RY2qSuFMhdxWknkEB7WVIDyrmFDMF5RL9EhB2doJ5mrlGFqQVPIxOV_3fsX-e4lpoduQLDbDU9gvk5alAFUCDODFGrSxTymi118xtCb-aqB6JUsPsvRKlhZsoE83tcu6RbdlN3aG_GyTm2RN4-MgJKQtVggupVph5RrDQcFPwKiTDTi4cyGiXWjXh3_n_wCUPoI8</recordid><startdate>199303</startdate><enddate>199303</enddate><creator>Tucker, Margaret A.</creator><creator>Fraser, Mary C.</creator><creator>Goldstein, Alisa M.</creator><creator>Elder, David E.</creator><creator>Guerry, DuPont</creator><creator>Organic, Sara M.</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199303</creationdate><title>Risk of Melanoma and Other Cancers in Melanoma-Prone Families</title><author>Tucker, Margaret A. ; Fraser, Mary C. ; Goldstein, Alisa M. ; Elder, David E. ; Guerry, DuPont ; Organic, Sara M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3112-44af80a8956da9e3c972fe1d1bc716f292682f4037efe018cbd62db8d2ec17073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Dermatology</topic><topic>Disease Susceptibility - complications</topic><topic>Dysplastic Nevus Syndrome - complications</topic><topic>Dysplastic Nevus Syndrome - epidemiology</topic><topic>Dysplastic Nevus Syndrome - pathology</topic><topic>Family Health</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanoma - complications</topic><topic>Melanoma - epidemiology</topic><topic>Melanoma - genetics</topic><topic>Melanoma - pathology</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tucker, Margaret A.</creatorcontrib><creatorcontrib>Fraser, Mary C.</creatorcontrib><creatorcontrib>Goldstein, Alisa M.</creatorcontrib><creatorcontrib>Elder, David E.</creatorcontrib><creatorcontrib>Guerry, DuPont</creatorcontrib><creatorcontrib>Organic, Sara M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tucker, Margaret A.</au><au>Fraser, Mary C.</au><au>Goldstein, Alisa M.</au><au>Elder, David E.</au><au>Guerry, DuPont</au><au>Organic, Sara M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of Melanoma and Other Cancers in Melanoma-Prone Families</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>1993-03</date><risdate>1993</risdate><volume>100</volume><issue>3</issue><spage>S350</spage><epage>S355</epage><pages>S350-S355</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><coden>JIDEAE</coden><abstract>We evaluated the risk of developing melanoma over time in members of 23 melanoma-prone families. All 23 families had dysplastic nevi as well as melanoma. Forty-seven melanomas occurred prospectively, all in family members with dysplastic nevi. The prospective melanomas were markedly thinner than the melanomas diagnosed prior to or at the time of the subject's entry into the study. The cumulative risk of melanoma by age 50 years among people with dysplastic nevi was 48.9±4.2%. Overall, the relative risk of a prospective melanoma among family members with previous melanoma was 229 (95% confidence interval 110–422). The risk varied by time interval and was 362 in the first 5 years, decreasing to 120 after 5 years. The risk of developing melanoma was 85 times increased (95% confidence interval 41–156) in family members with dysplastic nevi and also declined over time in this group. There was no significant excess of cancers other than melanoma. Close surveillance of these high-risk families has led to diagnosis of melanoma at an earlier developmental stage, which should result in a decrease in mortality over time.</abstract><cop>Danvers, MA</cop><pub>Elsevier Inc</pub><pmid>8440923</pmid><doi>10.1038/jid.1993.62</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Biological and medical sciences Child Dermatology Disease Susceptibility - complications Dysplastic Nevus Syndrome - complications Dysplastic Nevus Syndrome - epidemiology Dysplastic Nevus Syndrome - pathology Family Health Female Genetic Predisposition to Disease Humans Male Medical sciences Melanoma - complications Melanoma - epidemiology Melanoma - genetics Melanoma - pathology Middle Aged Neoplasm Invasiveness Prospective Studies Retrospective Studies Risk Factors Tumors of the skin and soft tissue. Premalignant lesions |
| title | Risk of Melanoma and Other Cancers in Melanoma-Prone Families |
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