Lactate Accumulation in Isolated Hypoxic Rat Ventricular Myocardium: Effect of Different Modulators of the Cyclic GMP System

: Different agents which are known to increase tissue levels of cyclic guanosine 3′5′‐monophosphate (cGMP), were found to decrease the lactate accumulation induced by hypoxia in isolated, non‐beating rat myocardium from the right ventricle. One μM sodium nitroprusside increased the intracellular cGM...

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Veröffentlicht in:	Pharmacology & toxicology 1993-01, Vol.72 (1), p.56-60
Hauptverfasser:	Ljusegren, Marie Ekstam, Axelsson, Krister L.
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors Animals Atrial Natriuretic Factor - pharmacology Biological and medical sciences Calcium Channel Blockers - pharmacology Cardiology. Vascular system Coronary heart disease Cyclic GMP - analogs & derivatives Cyclic GMP - metabolism Cyclic GMP - pharmacology Heart Heart Ventricles - drug effects Lactates - metabolism Lactic Acid Male Medical sciences Myocardium - metabolism Oxygen Consumption Rats Rats, Sprague-Dawley
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