Prevention of experimental autoimmune arthritis with a peptide fragment of type II collagen
Collagen arthritis is induced in inbred rats with the injection of native type II collagen. The pathogenesis of this experimental autoimmune disease is T cell dependent. This study demonstrates that collagen‐specific Tcells, derived from pathogenic and nonpathogenic rat Tcell lines, both recognize t...
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| Veröffentlicht in: | European journal of immunology 1993-03, Vol.23 (3), p.591-599 |
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| container_title | European journal of immunology |
| container_volume | 23 |
| creator | Ku, Grace Kronenberg, Mitchell Peacock, Derek J. Tempst, Paul Banquerigo, Mona Lisa Braun, Benjamin S. Reeve, Joseph R. Brahn, Ernest |
| description | Collagen arthritis is induced in inbred rats with the injection of native type II collagen. The pathogenesis of this experimental autoimmune disease is T cell dependent. This study demonstrates that collagen‐specific Tcells, derived from pathogenic and nonpathogenic rat Tcell lines, both recognize the same peptide epitope. The epitope, consisting of amino acids 58–73 of cyanogen bromide fragment 11 of type II collagen, was as effective as whole collagen in stimulating a panel of collagen‐specific rat/mouse Tcell hybridomas. This peptide may, therefore, constitute a dominant epitope for CD4+ rat Tcells in their response to type II collagen. Administration of the peptide to either neonatal or adult rats prevented the subsequent induction of experimental arthritis with whole collagen, demonstrating that the in vivo response to this dominant epitope is, therefore, relevant in the pathogenesis of arthritis. Despite its ability to prevent collagen‐induced arthritis, administration of this peptide in incomplete Freund's adjuvant intradermally did not induce disease. |
| doi_str_mv | 10.1002/eji.1830230302 |
| format | Article |
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The pathogenesis of this experimental autoimmune disease is T cell dependent. This study demonstrates that collagen‐specific Tcells, derived from pathogenic and nonpathogenic rat Tcell lines, both recognize the same peptide epitope. The epitope, consisting of amino acids 58–73 of cyanogen bromide fragment 11 of type II collagen, was as effective as whole collagen in stimulating a panel of collagen‐specific rat/mouse Tcell hybridomas. This peptide may, therefore, constitute a dominant epitope for CD4+ rat Tcells in their response to type II collagen. Administration of the peptide to either neonatal or adult rats prevented the subsequent induction of experimental arthritis with whole collagen, demonstrating that the in vivo response to this dominant epitope is, therefore, relevant in the pathogenesis of arthritis. Despite its ability to prevent collagen‐induced arthritis, administration of this peptide in incomplete Freund's adjuvant intradermally did not induce disease.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830230302</identifier><identifier>PMID: 7680609</identifier><identifier>CODEN: EJIMAF</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Amino Acid Sequence ; Animal model ; Animals ; Antibodies - immunology ; Arthritis, Experimental - prevention & control ; Biological and medical sciences ; Collagen - immunology ; Collagen arthritis ; Diseases of the osteoarticular system ; Epitopes ; Hypersensitivity, Delayed - immunology ; Immune Tolerance ; Immunization ; Inflammatory joint diseases ; Medical sciences ; Molecular Sequence Data ; Peptide therapy ; Peptides - chemistry ; Peptides - immunology ; Rats ; Rats, Inbred Strains ; T cell epitope ; T-Lymphocytes - immunology ; Tolerance</subject><ispartof>European journal of immunology, 1993-03, Vol.23 (3), p.591-599</ispartof><rights>Copyright © 1993 WILEY‐VCH Verlag GmbH & Co. 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The pathogenesis of this experimental autoimmune disease is T cell dependent. This study demonstrates that collagen‐specific Tcells, derived from pathogenic and nonpathogenic rat Tcell lines, both recognize the same peptide epitope. The epitope, consisting of amino acids 58–73 of cyanogen bromide fragment 11 of type II collagen, was as effective as whole collagen in stimulating a panel of collagen‐specific rat/mouse Tcell hybridomas. This peptide may, therefore, constitute a dominant epitope for CD4+ rat Tcells in their response to type II collagen. Administration of the peptide to either neonatal or adult rats prevented the subsequent induction of experimental arthritis with whole collagen, demonstrating that the in vivo response to this dominant epitope is, therefore, relevant in the pathogenesis of arthritis. Despite its ability to prevent collagen‐induced arthritis, administration of this peptide in incomplete Freund's adjuvant intradermally did not induce disease.</description><subject>Amino Acid Sequence</subject><subject>Animal model</subject><subject>Animals</subject><subject>Antibodies - immunology</subject><subject>Arthritis, Experimental - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Collagen - immunology</subject><subject>Collagen arthritis</subject><subject>Diseases of the osteoarticular system</subject><subject>Epitopes</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Immune Tolerance</subject><subject>Immunization</subject><subject>Inflammatory joint diseases</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Peptide therapy</subject><subject>Peptides - chemistry</subject><subject>Peptides - immunology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>T cell epitope</subject><subject>T-Lymphocytes - immunology</subject><subject>Tolerance</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPGzEQgK2KClLg2huSD4jbpp61vbaPKAKaKhIc6KmHlfHOgqN9Ye9C8-9xlIj2lotH8nzz-gj5DmwOjOU_cO3noDnLOUvPFzIDmUMmQMARmTEGIsuNZifkW4xrxpgppDkmx6rQrGBmRv48BHzDbvR9R_ua4t8Bg2_Th22oncbet-3UIbVhfAl-9JG--_GFWjrgMPoKaR3s8xbfFo-bAelySV3fNPYZuzPytbZNxPN9PCW_b28eFz-z1f3dcnG9ypxIF2TcCanyvNK1hKrQdWWUsYpLUSkNEg04pRRn0mgHqnIWJNNPwCtwiEblip-Sq13fIfSvE8axbH10mJbosJ9iqWQBHHJxEIRCGA7cJHC-A13oYwxYl0OyYsOmBFZutZdJe_lPeyq42HeenlqsPvG955S_3OdtdLZJ1jrn4ycmCq24KBJmdti7b3BzYGh582v53wofNjCaVA</recordid><startdate>199303</startdate><enddate>199303</enddate><creator>Ku, Grace</creator><creator>Kronenberg, Mitchell</creator><creator>Peacock, Derek J.</creator><creator>Tempst, Paul</creator><creator>Banquerigo, Mona Lisa</creator><creator>Braun, Benjamin S.</creator><creator>Reeve, Joseph R.</creator><creator>Brahn, Ernest</creator><general>WILEY‐VCH Verlag GmbH</general><general>Wiley-VCH</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199303</creationdate><title>Prevention of experimental autoimmune arthritis with a peptide fragment of type II collagen</title><author>Ku, Grace ; Kronenberg, Mitchell ; Peacock, Derek J. ; Tempst, Paul ; Banquerigo, Mona Lisa ; Braun, Benjamin S. ; Reeve, Joseph R. ; Brahn, Ernest</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4002-3c45722d8f51d68fd979a7354d7815e91c77730598c17dca1508b13d1cee97273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Amino Acid Sequence</topic><topic>Animal model</topic><topic>Animals</topic><topic>Antibodies - immunology</topic><topic>Arthritis, Experimental - prevention & control</topic><topic>Biological and medical sciences</topic><topic>Collagen - immunology</topic><topic>Collagen arthritis</topic><topic>Diseases of the osteoarticular system</topic><topic>Epitopes</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>Immune Tolerance</topic><topic>Immunization</topic><topic>Inflammatory joint diseases</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Peptide therapy</topic><topic>Peptides - chemistry</topic><topic>Peptides - immunology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>T cell epitope</topic><topic>T-Lymphocytes - immunology</topic><topic>Tolerance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ku, Grace</creatorcontrib><creatorcontrib>Kronenberg, Mitchell</creatorcontrib><creatorcontrib>Peacock, Derek J.</creatorcontrib><creatorcontrib>Tempst, Paul</creatorcontrib><creatorcontrib>Banquerigo, Mona Lisa</creatorcontrib><creatorcontrib>Braun, Benjamin S.</creatorcontrib><creatorcontrib>Reeve, Joseph R.</creatorcontrib><creatorcontrib>Brahn, Ernest</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ku, Grace</au><au>Kronenberg, Mitchell</au><au>Peacock, Derek J.</au><au>Tempst, Paul</au><au>Banquerigo, Mona Lisa</au><au>Braun, Benjamin S.</au><au>Reeve, Joseph R.</au><au>Brahn, Ernest</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of experimental autoimmune arthritis with a peptide fragment of type II collagen</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1993-03</date><risdate>1993</risdate><volume>23</volume><issue>3</issue><spage>591</spage><epage>599</epage><pages>591-599</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><coden>EJIMAF</coden><abstract>Collagen arthritis is induced in inbred rats with the injection of native type II collagen. The pathogenesis of this experimental autoimmune disease is T cell dependent. This study demonstrates that collagen‐specific Tcells, derived from pathogenic and nonpathogenic rat Tcell lines, both recognize the same peptide epitope. The epitope, consisting of amino acids 58–73 of cyanogen bromide fragment 11 of type II collagen, was as effective as whole collagen in stimulating a panel of collagen‐specific rat/mouse Tcell hybridomas. This peptide may, therefore, constitute a dominant epitope for CD4+ rat Tcells in their response to type II collagen. Administration of the peptide to either neonatal or adult rats prevented the subsequent induction of experimental arthritis with whole collagen, demonstrating that the in vivo response to this dominant epitope is, therefore, relevant in the pathogenesis of arthritis. Despite its ability to prevent collagen‐induced arthritis, administration of this peptide in incomplete Freund's adjuvant intradermally did not induce disease.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>7680609</pmid><doi>10.1002/eji.1830230302</doi><tpages>9</tpages></addata></record> |
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| ispartof | European journal of immunology, 1993-03, Vol.23 (3), p.591-599 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Amino Acid Sequence Animal model Animals Antibodies - immunology Arthritis, Experimental - prevention & control Biological and medical sciences Collagen - immunology Collagen arthritis Diseases of the osteoarticular system Epitopes Hypersensitivity, Delayed - immunology Immune Tolerance Immunization Inflammatory joint diseases Medical sciences Molecular Sequence Data Peptide therapy Peptides - chemistry Peptides - immunology Rats Rats, Inbred Strains T cell epitope T-Lymphocytes - immunology Tolerance |
| title | Prevention of experimental autoimmune arthritis with a peptide fragment of type II collagen |
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