Topical Tretinoin Treatment in Basal Cell Carcinoma
BACKGROUND. The efficiency of topical tretinoin was examined in a patient with basal cell carcinomas (BCC) for which conventional means of removal was inappropriate. METHODS. Topical tretinoin was used to treat multiple arsenic‐induced superficial BCCs in a 64‐year‐old woman. Topical tretinoin (0.05...
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| Veröffentlicht in: | The Journal of Dermatologic Surgery and Oncology 1993-03, Vol.19 (3), p.264-266 |
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| container_end_page | 266 |
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| container_issue | 3 |
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| container_title | The Journal of Dermatologic Surgery and Oncology |
| container_volume | 19 |
| creator | BRENNER, SARAH WOLF, RONNI DASCALU, DANA I. |
| description | BACKGROUND. The efficiency of topical tretinoin was examined in a patient with basal cell carcinomas (BCC) for which conventional means of removal was inappropriate.
METHODS. Topical tretinoin was used to treat multiple arsenic‐induced superficial BCCs in a 64‐year‐old woman. Topical tretinoin (0.05% twice daily) was administered to four lesions for 3 weeks followed by a 3‐week interruption.
RESULTS. After three cycles of treatment clinical healing of all the lesions was observed. Histopathological examination of the lesional biopsies showed no evidence of a tumor. However, 9 months later all four lesions relapsed and surgical excision disclosed BCC.
CONCLUSION. The data indicate that topical tretinoin treatment of multiple superficial BCCs induces clinical and pathological regression of the lesions with a high rate of relapse. This report suggests that topical tretinoin is not an effective therapy for the cure of arsenic‐induced superficial BCCs. |
| doi_str_mv | 10.1111/j.1524-4725.1993.tb00346.x |
| format | Article |
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METHODS. Topical tretinoin was used to treat multiple arsenic‐induced superficial BCCs in a 64‐year‐old woman. Topical tretinoin (0.05% twice daily) was administered to four lesions for 3 weeks followed by a 3‐week interruption.
RESULTS. After three cycles of treatment clinical healing of all the lesions was observed. Histopathological examination of the lesional biopsies showed no evidence of a tumor. However, 9 months later all four lesions relapsed and surgical excision disclosed BCC.
CONCLUSION. The data indicate that topical tretinoin treatment of multiple superficial BCCs induces clinical and pathological regression of the lesions with a high rate of relapse. This report suggests that topical tretinoin is not an effective therapy for the cure of arsenic‐induced superficial BCCs.</description><identifier>ISSN: 0148-0812</identifier><identifier>EISSN: 1524-4725</identifier><identifier>EISSN: 2374-846X</identifier><identifier>DOI: 10.1111/j.1524-4725.1993.tb00346.x</identifier><identifier>PMID: 8445111</identifier><identifier>CODEN: JDSODJ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Cutaneous ; Biological and medical sciences ; Carcinoma, Basal Cell - drug therapy ; Carcinoma, Basal Cell - pathology ; Female ; Humans ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Skin Neoplasms - drug therapy ; Skin Neoplasms - pathology ; Skin, nail, hair, dermoskeleton ; Tretinoin - therapeutic use</subject><ispartof>The Journal of Dermatologic Surgery and Oncology, 1993-03, Vol.19 (3), p.264-266</ispartof><rights>1993 American Society for Dermatologic Surgery, Inc.</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3984-b8a07db3bac6704fc19da055a466676b6d8f1039a7257c605fba25b179911d173</citedby><cites>FETCH-LOGICAL-c3984-b8a07db3bac6704fc19da055a466676b6d8f1039a7257c605fba25b179911d173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4649082$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8445111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BRENNER, SARAH</creatorcontrib><creatorcontrib>WOLF, RONNI</creatorcontrib><creatorcontrib>DASCALU, DANA I.</creatorcontrib><title>Topical Tretinoin Treatment in Basal Cell Carcinoma</title><title>The Journal of Dermatologic Surgery and Oncology</title><addtitle>J Dermatol Surg Oncol</addtitle><description>BACKGROUND. The efficiency of topical tretinoin was examined in a patient with basal cell carcinomas (BCC) for which conventional means of removal was inappropriate.
METHODS. Topical tretinoin was used to treat multiple arsenic‐induced superficial BCCs in a 64‐year‐old woman. Topical tretinoin (0.05% twice daily) was administered to four lesions for 3 weeks followed by a 3‐week interruption.
RESULTS. After three cycles of treatment clinical healing of all the lesions was observed. Histopathological examination of the lesional biopsies showed no evidence of a tumor. However, 9 months later all four lesions relapsed and surgical excision disclosed BCC.
CONCLUSION. The data indicate that topical tretinoin treatment of multiple superficial BCCs induces clinical and pathological regression of the lesions with a high rate of relapse. This report suggests that topical tretinoin is not an effective therapy for the cure of arsenic‐induced superficial BCCs.</description><subject>Administration, Cutaneous</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Basal Cell - drug therapy</subject><subject>Carcinoma, Basal Cell - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Skin Neoplasms - drug therapy</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin, nail, hair, dermoskeleton</subject><subject>Tretinoin - therapeutic use</subject><issn>0148-0812</issn><issn>1524-4725</issn><issn>2374-846X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1LwzAUhoMoc05_gjBEvGtNmq_GC0HnJwy8cLsOJ2kKHWs7kw63f2_Kyu7NRXLC-56TNw9CNwSnJK77VUp4xhImM54SpWjaGYwpE-nuBI2P0ikaY8LyBOckO0cXIaww5oxJOkKjnDEeJ40RXbSbysJ6uvCuq5q2avoKuto13TReniFEcebWcQNvo6OGS3RWwjq4q-GcoOXb62L2kcy_3j9nT_PEUpWzxOSAZWGoASskZqUlqgDMOTAhhBRGFHlJMFUQs0orMC8NZNwQqRQhBZF0gu4Ocze-_dm60Om6CjZGgca126AlFySLP4rGh4PR-jYE70q98VUNfq8J1j0xvdI9Ft1j0T0xPRDTu9h8PbyyNbUrjq0DoqjfDjqECKr00NgqHG1MMIXzLNoeD7bfau32_wigX76XmWD0Dy6EhgY</recordid><startdate>199303</startdate><enddate>199303</enddate><creator>BRENNER, SARAH</creator><creator>WOLF, RONNI</creator><creator>DASCALU, DANA I.</creator><general>Blackwell Publishing Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199303</creationdate><title>Topical Tretinoin Treatment in Basal Cell Carcinoma</title><author>BRENNER, SARAH ; WOLF, RONNI ; DASCALU, DANA I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3984-b8a07db3bac6704fc19da055a466676b6d8f1039a7257c605fba25b179911d173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Administration, Cutaneous</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Basal Cell - drug therapy</topic><topic>Carcinoma, Basal Cell - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Skin Neoplasms - drug therapy</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin, nail, hair, dermoskeleton</topic><topic>Tretinoin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BRENNER, SARAH</creatorcontrib><creatorcontrib>WOLF, RONNI</creatorcontrib><creatorcontrib>DASCALU, DANA I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of Dermatologic Surgery and Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BRENNER, SARAH</au><au>WOLF, RONNI</au><au>DASCALU, DANA I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topical Tretinoin Treatment in Basal Cell Carcinoma</atitle><jtitle>The Journal of Dermatologic Surgery and Oncology</jtitle><addtitle>J Dermatol Surg Oncol</addtitle><date>1993-03</date><risdate>1993</risdate><volume>19</volume><issue>3</issue><spage>264</spage><epage>266</epage><pages>264-266</pages><issn>0148-0812</issn><eissn>1524-4725</eissn><eissn>2374-846X</eissn><coden>JDSODJ</coden><abstract>BACKGROUND. The efficiency of topical tretinoin was examined in a patient with basal cell carcinomas (BCC) for which conventional means of removal was inappropriate.
METHODS. Topical tretinoin was used to treat multiple arsenic‐induced superficial BCCs in a 64‐year‐old woman. Topical tretinoin (0.05% twice daily) was administered to four lesions for 3 weeks followed by a 3‐week interruption.
RESULTS. After three cycles of treatment clinical healing of all the lesions was observed. Histopathological examination of the lesional biopsies showed no evidence of a tumor. However, 9 months later all four lesions relapsed and surgical excision disclosed BCC.
CONCLUSION. The data indicate that topical tretinoin treatment of multiple superficial BCCs induces clinical and pathological regression of the lesions with a high rate of relapse. This report suggests that topical tretinoin is not an effective therapy for the cure of arsenic‐induced superficial BCCs.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8445111</pmid><doi>10.1111/j.1524-4725.1993.tb00346.x</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0148-0812 |
| ispartof | The Journal of Dermatologic Surgery and Oncology, 1993-03, Vol.19 (3), p.264-266 |
| issn | 0148-0812 1524-4725 2374-846X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Administration, Cutaneous Biological and medical sciences Carcinoma, Basal Cell - drug therapy Carcinoma, Basal Cell - pathology Female Humans Medical sciences Middle Aged Pharmacology. Drug treatments Skin Neoplasms - drug therapy Skin Neoplasms - pathology Skin, nail, hair, dermoskeleton Tretinoin - therapeutic use |
| title | Topical Tretinoin Treatment in Basal Cell Carcinoma |
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