A Comparison of the Anti-rhinoviral Drug Binding Pocket in HRV14 and HRV1A

The three-dimensional structures of two human rhinovirus serotypes (HRV14 and HRV1A) are compared when complexed with various antiviral agents. Although these agents all bind into the same hydrophobic pocket, the exact viral-drug interactions differ. In the absence of drugs, the pocket is occupied b...

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Veröffentlicht in:	Journal of molecular biology 1993-03, Vol.230 (1), p.206-226
Hauptverfasser:	Kim, Kyung H., Willingmann, Peter, Gong, Zu Xun, Kremer, Marcia J., Chapman, Michael S., Minor, Iwona, Oliveira, Marcos A., Rossmann, Michael G., Andries, Koen, Diana, Guy D., Dutko, Frank J., McKinlay, Mark A., Pevear, Daniel C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibiotics. Antiinfectious agents. Antiparasitic agents antiviral Antiviral agents Antiviral Agents - chemistry Binding Sites Biological and medical sciences Capsid - ultrastructure Conserved Sequence Drug Design drugs HRV14 HRV1A Isoxazoles - chemistry Medical sciences Models, Molecular Molecular Sequence Data Pharmacology. Drug treatments Pyridazines - chemistry rhinovirus Rhinovirus - classification Rhinovirus - drug effects Rhinovirus - ultrastructure Sequence Alignment Serotyping Structure-Activity Relationship
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