Bone Marrow Clones Representing an Intermediate Stage of Development Between Hematopoietic Stem Cells and Pro-T-Lymphocyte or Pro-B-Lymphocyte Progenitors
We have established in culture several nontransformed bone marrow clones (called PR) that show phenotypic and genotypic characteristics that distinguish them from totipotent stem cells and lineage-restricted Pro-T lymphocytes, Pro-B lymphocytes, and myeloid cell progenitors. In vivo and/or in vitro...
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| Veröffentlicht in: | Blood 1993-03, Vol.81 (5), p.1222-1238 |
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| creator | Palacios, Ronald Samaridis, Jacqueline |
| description | We have established in culture several nontransformed bone marrow clones (called PR) that show phenotypic and genotypic characteristics that distinguish them from totipotent stem cells and lineage-restricted Pro-T lymphocytes, Pro-B lymphocytes, and myeloid cell progenitors. In vivo and/or in vitro the PR clones give rise to T lymphocytes, B lymphocytes, and some myeloid-lineage cells, but they appear not to be able to generate cells of the erythroid lineage, nor can they rescue mice from a lethal dose of irradiation. We conclude that the PR clones are precursor cells representing an intermediate stage of development between the totipotential stem cell and lineage-restricted progenitor cells. The results described here support a model of blood cell formation in which stem cell differentiation is a progressive process marked by the stepwise loss of self renewal and functional potential. In addition, they provide evidence that cytokines and specialized microenvironments can direct the fate of the developing multipotent progenitor cells. |
| doi_str_mv | 10.1182/blood.V81.5.1222.1222 |
| format | Article |
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In vivo and/or in vitro the PR clones give rise to T lymphocytes, B lymphocytes, and some myeloid-lineage cells, but they appear not to be able to generate cells of the erythroid lineage, nor can they rescue mice from a lethal dose of irradiation. We conclude that the PR clones are precursor cells representing an intermediate stage of development between the totipotential stem cell and lineage-restricted progenitor cells. The results described here support a model of blood cell formation in which stem cell differentiation is a progressive process marked by the stepwise loss of self renewal and functional potential. In addition, they provide evidence that cytokines and specialized microenvironments can direct the fate of the developing multipotent progenitor cells.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V81.5.1222.1222</identifier><identifier>PMID: 8443383</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Animals ; B-Lymphocytes - immunology ; B-Lymphocytes - physiology ; Base Sequence ; Biological and medical sciences ; Bone Marrow Cells ; Cell Differentiation ; Cell differentiation, maturation, development, hematopoiesis ; Cell physiology ; Clone Cells ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Growth Substances - pharmacology ; Hematopoietic Stem Cells - immunology ; Hematopoietic Stem Cells - physiology ; Mice ; Mice, Inbred CBA ; Molecular and cellular biology ; Molecular Sequence Data ; Phenotype ; Receptors, Antigen, T-Cell, alpha-beta - analysis ; Receptors, Antigen, T-Cell, gamma-delta - analysis ; T-Lymphocytes - immunology ; T-Lymphocytes - physiology</subject><ispartof>Blood, 1993-03, Vol.81 (5), p.1222-1238</ispartof><rights>1993 American Society of Hematology</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3512-b5dca4c42b78078e8eb1957e061b50665cff0bef50c4457f7a86e292eb22d96b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4680798$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8443383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Palacios, Ronald</creatorcontrib><creatorcontrib>Samaridis, Jacqueline</creatorcontrib><title>Bone Marrow Clones Representing an Intermediate Stage of Development Between Hematopoietic Stem Cells and Pro-T-Lymphocyte or Pro-B-Lymphocyte Progenitors</title><title>Blood</title><addtitle>Blood</addtitle><description>We have established in culture several nontransformed bone marrow clones (called PR) that show phenotypic and genotypic characteristics that distinguish them from totipotent stem cells and lineage-restricted Pro-T lymphocytes, Pro-B lymphocytes, and myeloid cell progenitors. In vivo and/or in vitro the PR clones give rise to T lymphocytes, B lymphocytes, and some myeloid-lineage cells, but they appear not to be able to generate cells of the erythroid lineage, nor can they rescue mice from a lethal dose of irradiation. We conclude that the PR clones are precursor cells representing an intermediate stage of development between the totipotential stem cell and lineage-restricted progenitor cells. The results described here support a model of blood cell formation in which stem cell differentiation is a progressive process marked by the stepwise loss of self renewal and functional potential. In addition, they provide evidence that cytokines and specialized microenvironments can direct the fate of the developing multipotent progenitor cells.</description><subject>Animals</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - physiology</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Cells</subject><subject>Cell Differentiation</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell physiology</subject><subject>Clone Cells</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Growth Substances - pharmacology</subject><subject>Hematopoietic Stem Cells - immunology</subject><subject>Hematopoietic Stem Cells - physiology</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>Phenotype</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - analysis</subject><subject>Receptors, Antigen, T-Cell, gamma-delta - analysis</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - physiology</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9uEzEQxi0EKmnhESr5gLhtsL32rveESPjTSkEgKFwt2zsbjHbtxXZa5VV42rpJVHHjMpZnfvN5PB9Cl5QsKZXsjRlD6Jc_JV2KJWWMHcITtKCCyYoQRp6iBSGkqXjX0ufoPKXfhFBeM3GGziTndS3rBfq7Ch7wZx1juMPrsVwS_gZzhAQ-O7_F2uNrnyFO0DudAX_Pegs4DPg93MIY5qlweAX5DsDjK5h0DnNwkJ0tKEx4DeOYikqPv8ZQ3VSb_TT_CnZfpEI85Fb_5kpiC97lENML9GzQY4KXp_MC_fj44WZ9VW2-fLpev9tUthaUVUb0VnPLmWklaSVIMLQTLZCGGkGaRthhIAYGQSznoh1aLRtgHQPDWN81pr5Ar4-6cwx_dpCymlyyZWztIeySakVDJGFdAcURtDGkFGFQc3STjntFiXrwRB08UcUTJdSDHYdQ-i5PD-xMWeNj18mEUn91qutk9ThE7a1Ljxhvyr86WbC3RwzKMm4dRJWsA2-LMRFsVn1w_xnkHiCHras</recordid><startdate>19930301</startdate><enddate>19930301</enddate><creator>Palacios, Ronald</creator><creator>Samaridis, Jacqueline</creator><general>Elsevier Inc</general><general>The Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930301</creationdate><title>Bone Marrow Clones Representing an Intermediate Stage of Development Between Hematopoietic Stem Cells and Pro-T-Lymphocyte or Pro-B-Lymphocyte Progenitors</title><author>Palacios, Ronald ; Samaridis, Jacqueline</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3512-b5dca4c42b78078e8eb1957e061b50665cff0bef50c4457f7a86e292eb22d96b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>B-Lymphocytes - immunology</topic><topic>B-Lymphocytes - physiology</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Cells</topic><topic>Cell Differentiation</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell physiology</topic><topic>Clone Cells</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Growth Substances - pharmacology</topic><topic>Hematopoietic Stem Cells - immunology</topic><topic>Hematopoietic Stem Cells - physiology</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Phenotype</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - analysis</topic><topic>Receptors, Antigen, T-Cell, gamma-delta - analysis</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palacios, Ronald</creatorcontrib><creatorcontrib>Samaridis, Jacqueline</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palacios, Ronald</au><au>Samaridis, Jacqueline</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone Marrow Clones Representing an Intermediate Stage of Development Between Hematopoietic Stem Cells and Pro-T-Lymphocyte or Pro-B-Lymphocyte Progenitors</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1993-03-01</date><risdate>1993</risdate><volume>81</volume><issue>5</issue><spage>1222</spage><epage>1238</epage><pages>1222-1238</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>We have established in culture several nontransformed bone marrow clones (called PR) that show phenotypic and genotypic characteristics that distinguish them from totipotent stem cells and lineage-restricted Pro-T lymphocytes, Pro-B lymphocytes, and myeloid cell progenitors. In vivo and/or in vitro the PR clones give rise to T lymphocytes, B lymphocytes, and some myeloid-lineage cells, but they appear not to be able to generate cells of the erythroid lineage, nor can they rescue mice from a lethal dose of irradiation. We conclude that the PR clones are precursor cells representing an intermediate stage of development between the totipotential stem cell and lineage-restricted progenitor cells. The results described here support a model of blood cell formation in which stem cell differentiation is a progressive process marked by the stepwise loss of self renewal and functional potential. In addition, they provide evidence that cytokines and specialized microenvironments can direct the fate of the developing multipotent progenitor cells.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>8443383</pmid><doi>10.1182/blood.V81.5.1222.1222</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-4971 |
| ispartof | Blood, 1993-03, Vol.81 (5), p.1222-1238 |
| issn | 0006-4971 1528-0020 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75608029 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals B-Lymphocytes - immunology B-Lymphocytes - physiology Base Sequence Biological and medical sciences Bone Marrow Cells Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell physiology Clone Cells Female Fundamental and applied biological sciences. Psychology Gene Expression Growth Substances - pharmacology Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - physiology Mice Mice, Inbred CBA Molecular and cellular biology Molecular Sequence Data Phenotype Receptors, Antigen, T-Cell, alpha-beta - analysis Receptors, Antigen, T-Cell, gamma-delta - analysis T-Lymphocytes - immunology T-Lymphocytes - physiology |
| title | Bone Marrow Clones Representing an Intermediate Stage of Development Between Hematopoietic Stem Cells and Pro-T-Lymphocyte or Pro-B-Lymphocyte Progenitors |
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