Human Herpesvirus-6 (HHV-6) Infection in Allogeneic Bone Marrow Transplant Recipients: Evidence of a Marrow-Suppressive Role for HHV-6 In Vivo
Sixteen adults were studied for the first 100 days after allogeneic bone marrow transplant to assess the pathogenic role of human herpesvirus-6 (HHV-6) infection in patients with unexplained febrile illnesses. HHV-6 was directly isolated from the blood of 6 patients. Analysis of the clinical courses...
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| Veröffentlicht in: | The Journal of infectious diseases 1993-03, Vol.167 (3), p.735-739 |
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| container_title | The Journal of infectious diseases |
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| creator | Drobyski, William R. Dunne, W. Michael Burd, Eileen M. Knox, Konstance K. Ash, Robert C. Horowitz, Mary M. Flomenberg, Neal Carrigan, Donald R. |
| description | Sixteen adults were studied for the first 100 days after allogeneic bone marrow transplant to assess the pathogenic role of human herpesvirus-6 (HHV-6) infection in patients with unexplained febrile illnesses. HHV-6 was directly isolated from the blood of 6 patients. Analysis of the clinical courses of these 16 patients revealed otherwise unexplained posttransplant marrow suppression in 5 patients. Idiopathic marrow suppression occurred more frequently in patients with concurrent HHV-6 viremia (4/6) than in those from whom HHV-6 was not isolated from peripheral blood (1/10, P < .05). An etiologic role for the virus was also supported by isolation of HHV-6 from the bone marrow of all 4 patients at the time of marrow suppression and by in vitro colony-forming unit (cfu) assays that demonstrated that HHV-6 could inhibit cfu-granulocytemacrophage and burst-forming unit-erythroid growth from human bone marrow. By restriction enzyme mapping, all clinical isolates were type B, suggesting that bone marrow transplant recipients may be preferentially infected with and reactivate this HHV-6 subtype. This study implicates HHV-6 as a novel cause of bone marrow suppression in marrow transplant recipients. |
| doi_str_mv | 10.1093/infdis/167.3.735 |
| format | Article |
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Michael ; Burd, Eileen M. ; Knox, Konstance K. ; Ash, Robert C. ; Horowitz, Mary M. ; Flomenberg, Neal ; Carrigan, Donald R.</creator><creatorcontrib>Drobyski, William R. ; Dunne, W. Michael ; Burd, Eileen M. ; Knox, Konstance K. ; Ash, Robert C. ; Horowitz, Mary M. ; Flomenberg, Neal ; Carrigan, Donald R.</creatorcontrib><description>Sixteen adults were studied for the first 100 days after allogeneic bone marrow transplant to assess the pathogenic role of human herpesvirus-6 (HHV-6) infection in patients with unexplained febrile illnesses. HHV-6 was directly isolated from the blood of 6 patients. Analysis of the clinical courses of these 16 patients revealed otherwise unexplained posttransplant marrow suppression in 5 patients. Idiopathic marrow suppression occurred more frequently in patients with concurrent HHV-6 viremia (4/6) than in those from whom HHV-6 was not isolated from peripheral blood (1/10, P < .05). An etiologic role for the virus was also supported by isolation of HHV-6 from the bone marrow of all 4 patients at the time of marrow suppression and by in vitro colony-forming unit (cfu) assays that demonstrated that HHV-6 could inhibit cfu-granulocytemacrophage and burst-forming unit-erythroid growth from human bone marrow. By restriction enzyme mapping, all clinical isolates were type B, suggesting that bone marrow transplant recipients may be preferentially infected with and reactivate this HHV-6 subtype. This study implicates HHV-6 as a novel cause of bone marrow suppression in marrow transplant recipients.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/167.3.735</identifier><identifier>PMID: 8382723</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Base Sequence ; Biological and medical sciences ; Bone Marrow - microbiology ; Bone Marrow - physiopathology ; Bone Marrow Transplantation ; Cohort Studies ; Colony-Forming Units Assay ; Fever - etiology ; Foscarnet - therapeutic use ; Ganciclovir - therapeutic use ; Hematologic and hematopoietic diseases ; Hematopoiesis ; Herpesviridae Infections - drug therapy ; Herpesviridae Infections - etiology ; Herpesviridae Infections - physiopathology ; Herpesvirus 6, Human - classification ; Herpesvirus 6, Human - isolation & purification ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Molecular Sequence Data ; Polymerase Chain Reaction ; Restriction Mapping ; Viremia</subject><ispartof>The Journal of infectious diseases, 1993-03, Vol.167 (3), p.735-739</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-1c658b3eb640f2d7d7404b68c3324a5f74a39fa2e2dea109dace71d503b4e5e93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4624762$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8382723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drobyski, William R.</creatorcontrib><creatorcontrib>Dunne, W. Michael</creatorcontrib><creatorcontrib>Burd, Eileen M.</creatorcontrib><creatorcontrib>Knox, Konstance K.</creatorcontrib><creatorcontrib>Ash, Robert C.</creatorcontrib><creatorcontrib>Horowitz, Mary M.</creatorcontrib><creatorcontrib>Flomenberg, Neal</creatorcontrib><creatorcontrib>Carrigan, Donald R.</creatorcontrib><title>Human Herpesvirus-6 (HHV-6) Infection in Allogeneic Bone Marrow Transplant Recipients: Evidence of a Marrow-Suppressive Role for HHV-6 In Vivo</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Sixteen adults were studied for the first 100 days after allogeneic bone marrow transplant to assess the pathogenic role of human herpesvirus-6 (HHV-6) infection in patients with unexplained febrile illnesses. HHV-6 was directly isolated from the blood of 6 patients. Analysis of the clinical courses of these 16 patients revealed otherwise unexplained posttransplant marrow suppression in 5 patients. Idiopathic marrow suppression occurred more frequently in patients with concurrent HHV-6 viremia (4/6) than in those from whom HHV-6 was not isolated from peripheral blood (1/10, P < .05). An etiologic role for the virus was also supported by isolation of HHV-6 from the bone marrow of all 4 patients at the time of marrow suppression and by in vitro colony-forming unit (cfu) assays that demonstrated that HHV-6 could inhibit cfu-granulocytemacrophage and burst-forming unit-erythroid growth from human bone marrow. By restriction enzyme mapping, all clinical isolates were type B, suggesting that bone marrow transplant recipients may be preferentially infected with and reactivate this HHV-6 subtype. This study implicates HHV-6 as a novel cause of bone marrow suppression in marrow transplant recipients.</description><subject>Adult</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - microbiology</subject><subject>Bone Marrow - physiopathology</subject><subject>Bone Marrow Transplantation</subject><subject>Cohort Studies</subject><subject>Colony-Forming Units Assay</subject><subject>Fever - etiology</subject><subject>Foscarnet - therapeutic use</subject><subject>Ganciclovir - therapeutic use</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematopoiesis</subject><subject>Herpesviridae Infections - drug therapy</subject><subject>Herpesviridae Infections - etiology</subject><subject>Herpesviridae Infections - physiopathology</subject><subject>Herpesvirus 6, Human - classification</subject><subject>Herpesvirus 6, Human - isolation & purification</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Polymerase Chain Reaction</subject><subject>Restriction Mapping</subject><subject>Viremia</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUFv1DAQhS0EKkvhzgXJB4TgkK1jO3bCra0KqbQVYluqiovlOGNkyNrBThb4E_xmDBt6msP75o3mPYSel2RdkoadOG97l05KIddsLVn1AK3KislCiJI9RCtCKC3KumkeoycpfSWEcCbkETqqWU0lZSv0u5132uMW4ghp7-KcCoFft-1tId7gS2_BTC547Dw-HYbwBTw4g8-CB3ylYww_8E3UPo2D9hPegnGjAz-lt_hi73rwBnCwWC9scT2PY4SU3B7wNgyAbYj43618Ct-6fXiKHlk9JHi2zGP06d3FzXlbbD68vzw_3RSGcToVpRFV3THoBCeW9rKXnPBO1IYxynVlJdessZoC7UHnoHptQJZ9RVjHoYKGHaNXB98xhu8zpEntXDIw5D8gzEnJShBZkyqD5ACaGFKKYNUY3U7HX6ok6m8F6lCByhUopnIFeeXF4j13O-jvF5bMs_5y0XUyerA5QJMN_mNcUC4FzVhxwFya4Oe9rOM3JSSTlWrvPqv67Op6y-826iP7AyDJn2Y</recordid><startdate>199303</startdate><enddate>199303</enddate><creator>Drobyski, William R.</creator><creator>Dunne, W. Michael</creator><creator>Burd, Eileen M.</creator><creator>Knox, Konstance K.</creator><creator>Ash, Robert C.</creator><creator>Horowitz, Mary M.</creator><creator>Flomenberg, Neal</creator><creator>Carrigan, Donald R.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199303</creationdate><title>Human Herpesvirus-6 (HHV-6) Infection in Allogeneic Bone Marrow Transplant Recipients: Evidence of a Marrow-Suppressive Role for HHV-6 In Vivo</title><author>Drobyski, William R. ; Dunne, W. Michael ; Burd, Eileen M. ; Knox, Konstance K. ; Ash, Robert C. ; Horowitz, Mary M. ; Flomenberg, Neal ; Carrigan, Donald R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-1c658b3eb640f2d7d7404b68c3324a5f74a39fa2e2dea109dace71d503b4e5e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - microbiology</topic><topic>Bone Marrow - physiopathology</topic><topic>Bone Marrow Transplantation</topic><topic>Cohort Studies</topic><topic>Colony-Forming Units Assay</topic><topic>Fever - etiology</topic><topic>Foscarnet - therapeutic use</topic><topic>Ganciclovir - therapeutic use</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematopoiesis</topic><topic>Herpesviridae Infections - drug therapy</topic><topic>Herpesviridae Infections - etiology</topic><topic>Herpesviridae Infections - physiopathology</topic><topic>Herpesvirus 6, Human - classification</topic><topic>Herpesvirus 6, Human - isolation & purification</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Polymerase Chain Reaction</topic><topic>Restriction Mapping</topic><topic>Viremia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drobyski, William R.</creatorcontrib><creatorcontrib>Dunne, W. Michael</creatorcontrib><creatorcontrib>Burd, Eileen M.</creatorcontrib><creatorcontrib>Knox, Konstance K.</creatorcontrib><creatorcontrib>Ash, Robert C.</creatorcontrib><creatorcontrib>Horowitz, Mary M.</creatorcontrib><creatorcontrib>Flomenberg, Neal</creatorcontrib><creatorcontrib>Carrigan, Donald R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drobyski, William R.</au><au>Dunne, W. Michael</au><au>Burd, Eileen M.</au><au>Knox, Konstance K.</au><au>Ash, Robert C.</au><au>Horowitz, Mary M.</au><au>Flomenberg, Neal</au><au>Carrigan, Donald R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Herpesvirus-6 (HHV-6) Infection in Allogeneic Bone Marrow Transplant Recipients: Evidence of a Marrow-Suppressive Role for HHV-6 In Vivo</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1993-03</date><risdate>1993</risdate><volume>167</volume><issue>3</issue><spage>735</spage><epage>739</epage><pages>735-739</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Sixteen adults were studied for the first 100 days after allogeneic bone marrow transplant to assess the pathogenic role of human herpesvirus-6 (HHV-6) infection in patients with unexplained febrile illnesses. HHV-6 was directly isolated from the blood of 6 patients. Analysis of the clinical courses of these 16 patients revealed otherwise unexplained posttransplant marrow suppression in 5 patients. Idiopathic marrow suppression occurred more frequently in patients with concurrent HHV-6 viremia (4/6) than in those from whom HHV-6 was not isolated from peripheral blood (1/10, P < .05). An etiologic role for the virus was also supported by isolation of HHV-6 from the bone marrow of all 4 patients at the time of marrow suppression and by in vitro colony-forming unit (cfu) assays that demonstrated that HHV-6 could inhibit cfu-granulocytemacrophage and burst-forming unit-erythroid growth from human bone marrow. By restriction enzyme mapping, all clinical isolates were type B, suggesting that bone marrow transplant recipients may be preferentially infected with and reactivate this HHV-6 subtype. This study implicates HHV-6 as a novel cause of bone marrow suppression in marrow transplant recipients.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>8382723</pmid><doi>10.1093/infdis/167.3.735</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1993-03, Vol.167 (3), p.735-739 |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adult Base Sequence Biological and medical sciences Bone Marrow - microbiology Bone Marrow - physiopathology Bone Marrow Transplantation Cohort Studies Colony-Forming Units Assay Fever - etiology Foscarnet - therapeutic use Ganciclovir - therapeutic use Hematologic and hematopoietic diseases Hematopoiesis Herpesviridae Infections - drug therapy Herpesviridae Infections - etiology Herpesviridae Infections - physiopathology Herpesvirus 6, Human - classification Herpesvirus 6, Human - isolation & purification Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Molecular Sequence Data Polymerase Chain Reaction Restriction Mapping Viremia |
| title | Human Herpesvirus-6 (HHV-6) Infection in Allogeneic Bone Marrow Transplant Recipients: Evidence of a Marrow-Suppressive Role for HHV-6 In Vivo |
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