Multiple brain systems generating the rat auditory evoked potential. I. Characterization of the auditory cortex response
The objectives of this study were to characterize the auditory cortex response in the rat and to examine its contributions to the auditory evoked potentials (AEPs) recorded from the dorsal and lateral skull. This was accomplished by simultaneously recording AEPs from the cortical surface and from sk...
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| Veröffentlicht in: | Brain research 1993-02, Vol.602 (2), p.240-250 |
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| creator | Simpson, Gregory V. Knight, Robert T. |
| description | The objectives of this study were to characterize the auditory cortex response in the rat and to examine its contributions to the auditory evoked potentials (AEPs) recorded from the dorsal and lateral skull. This was accomplished by simultaneously recording AEPs from the cortical surface and from skull screw electrodes in anesthetized animals. The initial positive-negative response (P17-N32) was largely restricted to the cortical region corresponding to area 41. More detailed examination of the AEP mapping revealed multiple subcomponents (P9, P14, P17, P19) underlying the initial positivity, with differing topographies. Stimulus-response properties further dissociated the multiple positive subcomponents Reversible local neurochemical suppression confirmed the auditory cortical origin of these AEPs. The auditory cortex-generated AEPs were refractory to barbiturate anesthesia which eliminated all dorsal skull AEPs, indicating that primary auditory cortical AEPs do not make a significant contribution to the dorsal skull-recorded (‘vertex’) AEPs. The findings raise issues regarding multiple parallel auditory processing systems and their associated AEPs. |
| doi_str_mv | 10.1016/0006-8993(93)90689-K |
| format | Article |
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I. Characterization of the auditory cortex response</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Simpson, Gregory V. ; Knight, Robert T.</creator><creatorcontrib>Simpson, Gregory V. ; Knight, Robert T.</creatorcontrib><description>The objectives of this study were to characterize the auditory cortex response in the rat and to examine its contributions to the auditory evoked potentials (AEPs) recorded from the dorsal and lateral skull. This was accomplished by simultaneously recording AEPs from the cortical surface and from skull screw electrodes in anesthetized animals. The initial positive-negative response (P17-N32) was largely restricted to the cortical region corresponding to area 41. More detailed examination of the AEP mapping revealed multiple subcomponents (P9, P14, P17, P19) underlying the initial positivity, with differing topographies. Stimulus-response properties further dissociated the multiple positive subcomponents Reversible local neurochemical suppression confirmed the auditory cortical origin of these AEPs. The auditory cortex-generated AEPs were refractory to barbiturate anesthesia which eliminated all dorsal skull AEPs, indicating that primary auditory cortical AEPs do not make a significant contribution to the dorsal skull-recorded (‘vertex’) AEPs. The findings raise issues regarding multiple parallel auditory processing systems and their associated AEPs.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(93)90689-K</identifier><identifier>PMID: 8448669</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Acoustic Stimulation ; Animals ; Auditory Cortex - drug effects ; Auditory Cortex - physiology ; Auditory cortex response ; Auditory evoked potential ; Biological and medical sciences ; Brain Mapping ; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation ; Electrodes ; Electroencephalography - drug effects ; Evoked Potentials, Auditory - drug effects ; Evoked Potentials, Auditory - physiology ; Evoked Potentials, Auditory, Brain Stem - drug effects ; Evoked Potentials, Auditory, Brain Stem - physiology ; Fundamental and applied biological sciences. Psychology ; gamma-Aminobutyric Acid - pharmacology ; Male ; Multiple auditory system ; Rat ; Rats ; Rats, Inbred F344 ; Reflex - drug effects ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1993-02, Vol.602 (2), p.240-250</ispartof><rights>1993 Elsevier Science Publishers B.V. All rights reserved</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-6a8e92f62bd5b9bace712d28628a53a323972d441fbb2744e595810cd5adfcf33</citedby><cites>FETCH-LOGICAL-c383t-6a8e92f62bd5b9bace712d28628a53a323972d441fbb2744e595810cd5adfcf33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(93)90689-K$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4545239$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8448669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simpson, Gregory V.</creatorcontrib><creatorcontrib>Knight, Robert T.</creatorcontrib><title>Multiple brain systems generating the rat auditory evoked potential. I. Characterization of the auditory cortex response</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The objectives of this study were to characterize the auditory cortex response in the rat and to examine its contributions to the auditory evoked potentials (AEPs) recorded from the dorsal and lateral skull. This was accomplished by simultaneously recording AEPs from the cortical surface and from skull screw electrodes in anesthetized animals. The initial positive-negative response (P17-N32) was largely restricted to the cortical region corresponding to area 41. More detailed examination of the AEP mapping revealed multiple subcomponents (P9, P14, P17, P19) underlying the initial positivity, with differing topographies. Stimulus-response properties further dissociated the multiple positive subcomponents Reversible local neurochemical suppression confirmed the auditory cortical origin of these AEPs. The auditory cortex-generated AEPs were refractory to barbiturate anesthesia which eliminated all dorsal skull AEPs, indicating that primary auditory cortical AEPs do not make a significant contribution to the dorsal skull-recorded (‘vertex’) AEPs. The findings raise issues regarding multiple parallel auditory processing systems and their associated AEPs.</description><subject>Acoustic Stimulation</subject><subject>Animals</subject><subject>Auditory Cortex - drug effects</subject><subject>Auditory Cortex - physiology</subject><subject>Auditory cortex response</subject><subject>Auditory evoked potential</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</subject><subject>Electrodes</subject><subject>Electroencephalography - drug effects</subject><subject>Evoked Potentials, Auditory - drug effects</subject><subject>Evoked Potentials, Auditory - physiology</subject><subject>Evoked Potentials, Auditory, Brain Stem - drug effects</subject><subject>Evoked Potentials, Auditory, Brain Stem - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gamma-Aminobutyric Acid - pharmacology</subject><subject>Male</subject><subject>Multiple auditory system</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Reflex - drug effects</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFvFCEUhYnR1LX6DzThwTT6MCsDDAMvJmbT1qZtfNFnwsCdFp0dRmCarr--jLvZR01IgNzv3AvnIPS2Juua1OITIURUUin2QbGPigipqutnaFXLllaCcvIcrY7IS_QqpZ_lypgiJ-hEci6FUCv0eDsP2U8D4C4aP-K0Sxm2Cd_BCNFkP97hfA-4HLGZnc8h7jA8hF_g8BQyjNmbYY2v1nhzb6KxGaL_U2RhxKH_qzyqbIgZHnGENIUxwWv0ojdDgjeH_RT9uDj_vvla3Xy7vNp8uakskyxXwkhQtBe0c02nOmOhramjUlBpGmYYZaqljvO67zracg6NamRNrGuM623P2Ck62_edYvg9Q8p665OFYTAjhDnpthGk4WXW_8BacMUEUQXke9DGkFKEXk_Rb03c6ZroJRm92K4X2_WylmT0dZG9O_Sfuy24o-gQRam_P9RNsmbooxmtT0eMN7wpny3Y5z0GxbQHD1En62G04HwEm7UL_t_veALKp6xc</recordid><startdate>19930205</startdate><enddate>19930205</enddate><creator>Simpson, Gregory V.</creator><creator>Knight, Robert T.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19930205</creationdate><title>Multiple brain systems generating the rat auditory evoked potential. I. Characterization of the auditory cortex response</title><author>Simpson, Gregory V. ; Knight, Robert T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-6a8e92f62bd5b9bace712d28628a53a323972d441fbb2744e595810cd5adfcf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Acoustic Stimulation</topic><topic>Animals</topic><topic>Auditory Cortex - drug effects</topic><topic>Auditory Cortex - physiology</topic><topic>Auditory cortex response</topic><topic>Auditory evoked potential</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</topic><topic>Electrodes</topic><topic>Electroencephalography - drug effects</topic><topic>Evoked Potentials, Auditory - drug effects</topic><topic>Evoked Potentials, Auditory - physiology</topic><topic>Evoked Potentials, Auditory, Brain Stem - drug effects</topic><topic>Evoked Potentials, Auditory, Brain Stem - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gamma-Aminobutyric Acid - pharmacology</topic><topic>Male</topic><topic>Multiple auditory system</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Reflex - drug effects</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simpson, Gregory V.</creatorcontrib><creatorcontrib>Knight, Robert T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simpson, Gregory V.</au><au>Knight, Robert T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple brain systems generating the rat auditory evoked potential. I. Characterization of the auditory cortex response</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1993-02-05</date><risdate>1993</risdate><volume>602</volume><issue>2</issue><spage>240</spage><epage>250</epage><pages>240-250</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The objectives of this study were to characterize the auditory cortex response in the rat and to examine its contributions to the auditory evoked potentials (AEPs) recorded from the dorsal and lateral skull. This was accomplished by simultaneously recording AEPs from the cortical surface and from skull screw electrodes in anesthetized animals. The initial positive-negative response (P17-N32) was largely restricted to the cortical region corresponding to area 41. More detailed examination of the AEP mapping revealed multiple subcomponents (P9, P14, P17, P19) underlying the initial positivity, with differing topographies. Stimulus-response properties further dissociated the multiple positive subcomponents Reversible local neurochemical suppression confirmed the auditory cortical origin of these AEPs. The auditory cortex-generated AEPs were refractory to barbiturate anesthesia which eliminated all dorsal skull AEPs, indicating that primary auditory cortical AEPs do not make a significant contribution to the dorsal skull-recorded (‘vertex’) AEPs. The findings raise issues regarding multiple parallel auditory processing systems and their associated AEPs.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8448669</pmid><doi>10.1016/0006-8993(93)90689-K</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acoustic Stimulation Animals Auditory Cortex - drug effects Auditory Cortex - physiology Auditory cortex response Auditory evoked potential Biological and medical sciences Brain Mapping Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Electrodes Electroencephalography - drug effects Evoked Potentials, Auditory - drug effects Evoked Potentials, Auditory - physiology Evoked Potentials, Auditory, Brain Stem - drug effects Evoked Potentials, Auditory, Brain Stem - physiology Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - pharmacology Male Multiple auditory system Rat Rats Rats, Inbred F344 Reflex - drug effects Vertebrates: nervous system and sense organs |
| title | Multiple brain systems generating the rat auditory evoked potential. I. Characterization of the auditory cortex response |
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