Does HCG treatment induce inflammation-like changes in undescended testes in boys?
Twenty-two cryptorchid boys previously unsuccessfully treated with human chorionic gonadotropin (hCG) were operated. Testicular biopsies were taken and a routine orchidopexy was performed in each case. As controls eight cryptorchid boys without prior hormonal treatment were operated in the same way....
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| Veröffentlicht in: | Journal of pediatric surgery 1993-02, Vol.28 (2), p.254-258 |
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| container_end_page | 258 |
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| container_issue | 2 |
| container_start_page | 254 |
| container_title | Journal of pediatric surgery |
| container_volume | 28 |
| creator | Hjertkvist, Mats Läckgren, Göran Plöen, Leif Bergh, Anders |
| description | Twenty-two cryptorchid boys previously unsuccessfully treated with human chorionic gonadotropin (hCG) were operated. Testicular biopsies were taken and a routine orchidopexy was performed in each case. As controls eight cryptorchid boys without prior hormonal treatment were operated in the same way. A mild inflammation-like reaction was found in the cryptorchid testes in the period immediately following the last hCG injection. However, in testes studied 6 to 12 months after the last hCG injection there were no apparent signs of hCG-induced tubular damage. |
| doi_str_mv | 10.1016/S0022-3468(05)80288-X |
| format | Article |
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Testicular biopsies were taken and a routine orchidopexy was performed in each case. As controls eight cryptorchid boys without prior hormonal treatment were operated in the same way. A mild inflammation-like reaction was found in the cryptorchid testes in the period immediately following the last hCG injection. However, in testes studied 6 to 12 months after the last hCG injection there were no apparent signs of hCG-induced tubular damage.</description><identifier>ISSN: 0022-3468</identifier><identifier>EISSN: 1531-5037</identifier><identifier>DOI: 10.1016/S0022-3468(05)80288-X</identifier><identifier>PMID: 8094747</identifier><identifier>CODEN: JPDSA3</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Biological and medical sciences ; Biopsy ; Child ; Child, Preschool ; Chorionic Gonadotropin - administration & dosage ; Chorionic Gonadotropin - adverse effects ; Chorionic Gonadotropin - therapeutic use ; Cryptorchidism ; Cryptorchidism - drug therapy ; Cryptorchidism - pathology ; Cryptorchidism - surgery ; Erythrocytes - drug effects ; Follow-Up Studies ; Hormones. Endocrine system ; Hospitals, University ; human chorionic gonadotropin ; Humans ; Inflammation ; Leydig Cells - drug effects ; Male ; Medical sciences ; Microcirculation - drug effects ; Neutrophils - drug effects ; Pharmacology. Drug treatments ; Sweden ; Time Factors ; Treatment Failure</subject><ispartof>Journal of pediatric surgery, 1993-02, Vol.28 (2), p.254-258</ispartof><rights>1993 W.B. Saunders Company. 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Testicular biopsies were taken and a routine orchidopexy was performed in each case. As controls eight cryptorchid boys without prior hormonal treatment were operated in the same way. A mild inflammation-like reaction was found in the cryptorchid testes in the period immediately following the last hCG injection. However, in testes studied 6 to 12 months after the last hCG injection there were no apparent signs of hCG-induced tubular damage.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chorionic Gonadotropin - administration & dosage</subject><subject>Chorionic Gonadotropin - adverse effects</subject><subject>Chorionic Gonadotropin - therapeutic use</subject><subject>Cryptorchidism</subject><subject>Cryptorchidism - drug therapy</subject><subject>Cryptorchidism - pathology</subject><subject>Cryptorchidism - surgery</subject><subject>Erythrocytes - drug effects</subject><subject>Follow-Up Studies</subject><subject>Hormones. Endocrine system</subject><subject>Hospitals, University</subject><subject>human chorionic gonadotropin</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Leydig Cells - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microcirculation - drug effects</subject><subject>Neutrophils - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Sweden</subject><subject>Time Factors</subject><subject>Treatment Failure</subject><issn>0022-3468</issn><issn>1531-5037</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtr3DAQgEVISTZpfsKCDyE0B6cjyZK9p1C27W4gUOgDchOyNEqU2HIi2YX8-2of7LU6aGDmm9HoI2RO4YYClZ9_ATBW8ko2n0BcN8Capnw4IjMqOC0F8PqYzA7IKTlL6Rkgp4GekJMGFlVd1TPy8-uAqVgvV8UYUY89hrHwwU4Gc3Cd7ns9-iGUnX_Bwjzp8JhxH4opWEwG822LEdO4y7bDe7r9SD443SW82Mdz8uf7t9_LdXn_Y3W3_HJfmoo2Y2kZlxJQL6QAZjhvazT5SMnaWhohaypxUaETxlUtA8fAZgy4pq5tnRX8nFzt5r7G4W3KO6je55W6TgccpqRqIfP_Ocug2IEmDilFdOo1-l7Hd0VBbVyqrUu1EaVAqK1L9ZD75vsHprZHe-jay8v1y31dJ6M7F3UwPh2wqgYuGpmx2x2GWcZfj1El4zEYtD6iGZUd_H8W-Qc-rpC_</recordid><startdate>19930201</startdate><enddate>19930201</enddate><creator>Hjertkvist, Mats</creator><creator>Läckgren, Göran</creator><creator>Plöen, Leif</creator><creator>Bergh, Anders</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930201</creationdate><title>Does HCG treatment induce inflammation-like changes in undescended testes in boys?</title><author>Hjertkvist, Mats ; Läckgren, Göran ; Plöen, Leif ; Bergh, Anders</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-d23660ea96502c33b7ecccc662b76c56716e94ef5cf4b20f20d2c303a1fbbfd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chorionic Gonadotropin - administration & dosage</topic><topic>Chorionic Gonadotropin - adverse effects</topic><topic>Chorionic Gonadotropin - therapeutic use</topic><topic>Cryptorchidism</topic><topic>Cryptorchidism - drug therapy</topic><topic>Cryptorchidism - pathology</topic><topic>Cryptorchidism - surgery</topic><topic>Erythrocytes - drug effects</topic><topic>Follow-Up Studies</topic><topic>Hormones. Endocrine system</topic><topic>Hospitals, University</topic><topic>human chorionic gonadotropin</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Leydig Cells - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microcirculation - drug effects</topic><topic>Neutrophils - drug effects</topic><topic>Pharmacology. 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Testicular biopsies were taken and a routine orchidopexy was performed in each case. As controls eight cryptorchid boys without prior hormonal treatment were operated in the same way. A mild inflammation-like reaction was found in the cryptorchid testes in the period immediately following the last hCG injection. However, in testes studied 6 to 12 months after the last hCG injection there were no apparent signs of hCG-induced tubular damage.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>8094747</pmid><doi>10.1016/S0022-3468(05)80288-X</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of pediatric surgery, 1993-02, Vol.28 (2), p.254-258 |
| issn | 0022-3468 1531-5037 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Biopsy Child Child, Preschool Chorionic Gonadotropin - administration & dosage Chorionic Gonadotropin - adverse effects Chorionic Gonadotropin - therapeutic use Cryptorchidism Cryptorchidism - drug therapy Cryptorchidism - pathology Cryptorchidism - surgery Erythrocytes - drug effects Follow-Up Studies Hormones. Endocrine system Hospitals, University human chorionic gonadotropin Humans Inflammation Leydig Cells - drug effects Male Medical sciences Microcirculation - drug effects Neutrophils - drug effects Pharmacology. Drug treatments Sweden Time Factors Treatment Failure |
| title | Does HCG treatment induce inflammation-like changes in undescended testes in boys? |
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