Effect of denervation and colchicine treatment of the nerve on electrical and chemical excitability of frog tonic muscle fibre
In order to investigate the role of axoplasmic transport in controlling the acetylcholine sensitivity and action potential generation in frog tonic muscle fibres, a comparison of changes produced in these fibres by denervation or by application of colchicine to the nerve was performed. Extrajunction...
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| Veröffentlicht in: | Neuroscience 1981-01, Vol.6 (2), p.217-222 |
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| creator | Nasledov, G.A. Radzjukevich, T.L. |
| description | In order to investigate the role of axoplasmic transport in controlling the acetylcholine sensitivity and action potential generation in frog tonic muscle fibres, a comparison of changes produced in these fibres by denervation or by application of colchicine to the nerve was performed. Extrajunctional cholinergic sensitivity appeared both after colchicine treatment and after denervation. However, action potential generation appeared after denervation but not after colchicine treatment. Insensitivity of the factor controlling action potential generation to colchicine, which is known to interrupt fast axonal flow, and the low rate of its transport (determined by the time difference in action potential occurrence at various lengths of the nerve stump after denervation and coming to about 1.6 mm/day) suggest that the tropic factor responsible for the suppression of action potentials in tonic fibres is moved by slow axonal transport.
It is concluded that the action potential mechanism in tonic fibres is controlled by the axonal flow of substances which differ from these controlling the acetylcholine receptors. |
| doi_str_mv | 10.1016/0306-4522(81)90057-9 |
| format | Article |
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It is concluded that the action potential mechanism in tonic fibres is controlled by the axonal flow of substances which differ from these controlling the acetylcholine receptors.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/0306-4522(81)90057-9</identifier><identifier>PMID: 6164008</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>acetylchonine ; ACh ; action potential ; Action Potentials - drug effects ; Animals ; Axonal Transport ; Colchicine - pharmacology ; Male ; Membrane Potentials - drug effects ; Motor Endplate - drug effects ; Motor Endplate - physiology ; Muscle Denervation ; Muscles - drug effects ; Muscles - physiology ; Rana temporaria ; Space life sciences</subject><ispartof>Neuroscience, 1981-01, Vol.6 (2), p.217-222</ispartof><rights>1981 IBRO</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-acfdd9846880778c4e861387bb054a9f6545b6c4b3fb39aaeaacc524bcc692ff3</citedby><cites>FETCH-LOGICAL-c357t-acfdd9846880778c4e861387bb054a9f6545b6c4b3fb39aaeaacc524bcc692ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0306-4522(81)90057-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6164008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nasledov, G.A.</creatorcontrib><creatorcontrib>Radzjukevich, T.L.</creatorcontrib><title>Effect of denervation and colchicine treatment of the nerve on electrical and chemical excitability of frog tonic muscle fibre</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>In order to investigate the role of axoplasmic transport in controlling the acetylcholine sensitivity and action potential generation in frog tonic muscle fibres, a comparison of changes produced in these fibres by denervation or by application of colchicine to the nerve was performed. Extrajunctional cholinergic sensitivity appeared both after colchicine treatment and after denervation. However, action potential generation appeared after denervation but not after colchicine treatment. Insensitivity of the factor controlling action potential generation to colchicine, which is known to interrupt fast axonal flow, and the low rate of its transport (determined by the time difference in action potential occurrence at various lengths of the nerve stump after denervation and coming to about 1.6 mm/day) suggest that the tropic factor responsible for the suppression of action potentials in tonic fibres is moved by slow axonal transport.
It is concluded that the action potential mechanism in tonic fibres is controlled by the axonal flow of substances which differ from these controlling the acetylcholine receptors.</description><subject>acetylchonine</subject><subject>ACh</subject><subject>action potential</subject><subject>Action Potentials - drug effects</subject><subject>Animals</subject><subject>Axonal Transport</subject><subject>Colchicine - pharmacology</subject><subject>Male</subject><subject>Membrane Potentials - drug effects</subject><subject>Motor Endplate - drug effects</subject><subject>Motor Endplate - physiology</subject><subject>Muscle Denervation</subject><subject>Muscles - drug effects</subject><subject>Muscles - physiology</subject><subject>Rana temporaria</subject><subject>Space life sciences</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1vFDEQhi1EFI7APwDJFYJig33rr22QUBQ-pEhpQm3Zs2POaHcdbF9EGn473rtTSqaxRvO8Y81DyBvOLjnj6iPrmeqE3G7fG_5hYEzqbnhGNtzovtNSiOdk84S8IC9L-cVaSdGfk3PFlWDMbMjf6xAQKk2BjrhgfnA1poW6ZaSQJthFiAvSmtHVGZcDV3dIVxJpA3Fq6RzBTcfMDudDg38gVufjFOvjGgo5_aQ1LRHovC8wIQ3RZ3xFzoKbCr4-vRfkx5fru6tv3c3t1-9Xn2866KWunYMwjoMRyhimtQGBRvHeaO_bPW4ISgrpFQjfB98PzqFzAHIrPIAatiH0F-Tdce99Tr_3WKqdYwGcJrdg2herpWputGygOIKQUykZg73PcXb50XJmV-12dWpXp9Zwe9BuhxZ7e9q_9zOOT6GT5zb_dJxjO_IhYrYFIi6AY8xNoB1T_P8H_wD6tZPf</recordid><startdate>19810101</startdate><enddate>19810101</enddate><creator>Nasledov, G.A.</creator><creator>Radzjukevich, T.L.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19810101</creationdate><title>Effect of denervation and colchicine treatment of the nerve on electrical and chemical excitability of frog tonic muscle fibre</title><author>Nasledov, G.A. ; Radzjukevich, T.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-acfdd9846880778c4e861387bb054a9f6545b6c4b3fb39aaeaacc524bcc692ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>acetylchonine</topic><topic>ACh</topic><topic>action potential</topic><topic>Action Potentials - drug effects</topic><topic>Animals</topic><topic>Axonal Transport</topic><topic>Colchicine - pharmacology</topic><topic>Male</topic><topic>Membrane Potentials - drug effects</topic><topic>Motor Endplate - drug effects</topic><topic>Motor Endplate - physiology</topic><topic>Muscle Denervation</topic><topic>Muscles - drug effects</topic><topic>Muscles - physiology</topic><topic>Rana temporaria</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nasledov, G.A.</creatorcontrib><creatorcontrib>Radzjukevich, T.L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nasledov, G.A.</au><au>Radzjukevich, T.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of denervation and colchicine treatment of the nerve on electrical and chemical excitability of frog tonic muscle fibre</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1981-01-01</date><risdate>1981</risdate><volume>6</volume><issue>2</issue><spage>217</spage><epage>222</epage><pages>217-222</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>In order to investigate the role of axoplasmic transport in controlling the acetylcholine sensitivity and action potential generation in frog tonic muscle fibres, a comparison of changes produced in these fibres by denervation or by application of colchicine to the nerve was performed. Extrajunctional cholinergic sensitivity appeared both after colchicine treatment and after denervation. However, action potential generation appeared after denervation but not after colchicine treatment. Insensitivity of the factor controlling action potential generation to colchicine, which is known to interrupt fast axonal flow, and the low rate of its transport (determined by the time difference in action potential occurrence at various lengths of the nerve stump after denervation and coming to about 1.6 mm/day) suggest that the tropic factor responsible for the suppression of action potentials in tonic fibres is moved by slow axonal transport.
It is concluded that the action potential mechanism in tonic fibres is controlled by the axonal flow of substances which differ from these controlling the acetylcholine receptors.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>6164008</pmid><doi>10.1016/0306-4522(81)90057-9</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 1981-01, Vol.6 (2), p.217-222 |
| issn | 0306-4522 1873-7544 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | acetylchonine ACh action potential Action Potentials - drug effects Animals Axonal Transport Colchicine - pharmacology Male Membrane Potentials - drug effects Motor Endplate - drug effects Motor Endplate - physiology Muscle Denervation Muscles - drug effects Muscles - physiology Rana temporaria Space life sciences |
| title | Effect of denervation and colchicine treatment of the nerve on electrical and chemical excitability of frog tonic muscle fibre |
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