Platelet-activating factor secreted by DDAVP-treated monocytes mediates von willebrand factor release from endothelial cells
We have previously shown that although DDAVP (1‐deamino‐8‐D‐arginine vasopressin), a synthetic analogue of the natural hormone arginine vasopressin, does not directly promote release of vWf from human umbilical vein endothelial cells (ECs), enhanced release does occur when ECs were exposed to either...
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Veröffentlicht in: | Journal of cellular physiology 1993-03, Vol.154 (3), p.496-505 |
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description | We have previously shown that although DDAVP (1‐deamino‐8‐D‐arginine vasopressin), a synthetic analogue of the natural hormone arginine vasopressin, does not directly promote release of vWf from human umbilical vein endothelial cells (ECs), enhanced release does occur when ECs were exposed to either monocytes or to supernatants recovered from DDAVP‐treated monocytes. In the present study, we have found that exposure of monocytes to DDAVP did not increase secretion of interleukins (IL)‐1β, IL‐6, IL‐8, tumor necrosis factor (TNF‐α), growth factors G‐CSF (granulocyte‐), GM‐CSF (granulocyte, monocyte‐colony stimulating factor), prostaglandins (PG) E2, PGF2α, or PGI2 or purine nucleotides such as ATP and ADP. However, increased levels of platelet‐activating factor (PAF) were secreted by DDAVP‐treated monocytes in a time‐ and dose‐dependent manner that positively correlated with the enhancement in vWf release from ECs. Moreover, this effect could also be elicited when lipid extracts of these supernatants or purified PAF were added directly to ECs. This response could be inhibited with (±)‐trans‐2,5‐Bis(3,4,5‐trimethoxyphenyl)‐1,3‐dioxolane, a specific PAF receptor antagonist, when the ECs were exposed to supernatants from DDAVP‐treated monocytes or to pure PAF. The present data indicate that enhanced secretion of PAF from monocytes is one mechanism whereby DDAVP can provoke release of vWf from ECs. © 1993 Wiley‐Liss, Inc. |
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S. ; Aye, M. T. ; Ganz, P. R.</creator><creatorcontrib>Hashemi, S. ; Palmer, D. S. ; Aye, M. T. ; Ganz, P. R.</creatorcontrib><description>We have previously shown that although DDAVP (1‐deamino‐8‐D‐arginine vasopressin), a synthetic analogue of the natural hormone arginine vasopressin, does not directly promote release of vWf from human umbilical vein endothelial cells (ECs), enhanced release does occur when ECs were exposed to either monocytes or to supernatants recovered from DDAVP‐treated monocytes. In the present study, we have found that exposure of monocytes to DDAVP did not increase secretion of interleukins (IL)‐1β, IL‐6, IL‐8, tumor necrosis factor (TNF‐α), growth factors G‐CSF (granulocyte‐), GM‐CSF (granulocyte, monocyte‐colony stimulating factor), prostaglandins (PG) E2, PGF2α, or PGI2 or purine nucleotides such as ATP and ADP. However, increased levels of platelet‐activating factor (PAF) were secreted by DDAVP‐treated monocytes in a time‐ and dose‐dependent manner that positively correlated with the enhancement in vWf release from ECs. Moreover, this effect could also be elicited when lipid extracts of these supernatants or purified PAF were added directly to ECs. This response could be inhibited with (±)‐trans‐2,5‐Bis(3,4,5‐trimethoxyphenyl)‐1,3‐dioxolane, a specific PAF receptor antagonist, when the ECs were exposed to supernatants from DDAVP‐treated monocytes or to pure PAF. The present data indicate that enhanced secretion of PAF from monocytes is one mechanism whereby DDAVP can provoke release of vWf from ECs. © 1993 Wiley‐Liss, Inc.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.1041540307</identifier><identifier>PMID: 8436598</identifier><identifier>CODEN: JCLLAX</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenosine Diphosphate - metabolism ; Adenosine Triphosphate - metabolism ; Biological and medical sciences ; Cells, Cultured ; Cytokines - metabolism ; Deamino Arginine Vasopressin - pharmacology ; Dioxolanes - pharmacology ; Endothelium, Vascular - metabolism ; Epoprostenol - metabolism ; Fundamental and applied biological sciences. Psychology ; Humans ; Kinetics ; Monocytes - drug effects ; Monocytes - metabolism ; Platelet Activating Factor - metabolism ; Platelet Activating Factor - pharmacology ; Prostaglandins - metabolism ; Vertebrates: blood, hematopoietic organs, reticuloendothelial system ; von Willebrand Factor - metabolism</subject><ispartof>Journal of cellular physiology, 1993-03, Vol.154 (3), p.496-505</ispartof><rights>Copyright © 1993 Wiley‐Liss, Inc.</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4077-15cd8c4ef468c5dfa9c763bb0912767226eb044442739b57ca37f08a9d76c7283</citedby><cites>FETCH-LOGICAL-c4077-15cd8c4ef468c5dfa9c763bb0912767226eb044442739b57ca37f08a9d76c7283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.1041540307$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.1041540307$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4660989$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8436598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashemi, S.</creatorcontrib><creatorcontrib>Palmer, D. S.</creatorcontrib><creatorcontrib>Aye, M. T.</creatorcontrib><creatorcontrib>Ganz, P. R.</creatorcontrib><title>Platelet-activating factor secreted by DDAVP-treated monocytes mediates von willebrand factor release from endothelial cells</title><title>Journal of cellular physiology</title><addtitle>J. Cell. Physiol</addtitle><description>We have previously shown that although DDAVP (1‐deamino‐8‐D‐arginine vasopressin), a synthetic analogue of the natural hormone arginine vasopressin, does not directly promote release of vWf from human umbilical vein endothelial cells (ECs), enhanced release does occur when ECs were exposed to either monocytes or to supernatants recovered from DDAVP‐treated monocytes. In the present study, we have found that exposure of monocytes to DDAVP did not increase secretion of interleukins (IL)‐1β, IL‐6, IL‐8, tumor necrosis factor (TNF‐α), growth factors G‐CSF (granulocyte‐), GM‐CSF (granulocyte, monocyte‐colony stimulating factor), prostaglandins (PG) E2, PGF2α, or PGI2 or purine nucleotides such as ATP and ADP. However, increased levels of platelet‐activating factor (PAF) were secreted by DDAVP‐treated monocytes in a time‐ and dose‐dependent manner that positively correlated with the enhancement in vWf release from ECs. Moreover, this effect could also be elicited when lipid extracts of these supernatants or purified PAF were added directly to ECs. This response could be inhibited with (±)‐trans‐2,5‐Bis(3,4,5‐trimethoxyphenyl)‐1,3‐dioxolane, a specific PAF receptor antagonist, when the ECs were exposed to supernatants from DDAVP‐treated monocytes or to pure PAF. The present data indicate that enhanced secretion of PAF from monocytes is one mechanism whereby DDAVP can provoke release of vWf from ECs. © 1993 Wiley‐Liss, Inc.</description><subject>Adenosine Diphosphate - metabolism</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Cytokines - metabolism</subject><subject>Deamino Arginine Vasopressin - pharmacology</subject><subject>Dioxolanes - pharmacology</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Epoprostenol - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - metabolism</subject><subject>Platelet Activating Factor - metabolism</subject><subject>Platelet Activating Factor - pharmacology</subject><subject>Prostaglandins - metabolism</subject><subject>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><subject>von Willebrand Factor - metabolism</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1v1DAQxS0EKkvhyg3JB8QtxYm_4mO1hZZVVYL4vFmOMwEXJ1lsb2Gl_vF1tNtFnPDFo5n33ox-CD0vyUlJSPX62q5zwUrOCCXyAVqURMmCCV49RIssKAvFWfkYPYnxmhCiFKVH6KhmVHBVL9Bt400CD6kwNrkbk9z4Hfe5ngKOYAMk6HC7xWdnp1-aIgUwc2OYxsluE0Q8QOfMXNxMI_7tvIc2mLG7jwg52kTAfZgGDGM3pR_gnfHYgvfxKXrUGx_h2f4_Rp_fvvm0vCgu35-_W55eFpYRKYuS2662DHomasu73igrBW1bospKCllVAlrC8qskVS2X1lDZk9qoTgorq5oeo1e73HWYfm0gJj24OF9gRpg2UUvOlZJcZeHJTmjDFGOAXq-DG0zY6pLoGbfOuPVf3NnwYp-8aTOKg3zPN89f7ucmWuP7zMa6eJAxIYiq571qJ8sEYfufpXq1bP45odh5XUzw5-A14acWkkquv16d62b1sVGrbxf6A70DV8mpag</recordid><startdate>199303</startdate><enddate>199303</enddate><creator>Hashemi, S.</creator><creator>Palmer, D. S.</creator><creator>Aye, M. T.</creator><creator>Ganz, P. R.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199303</creationdate><title>Platelet-activating factor secreted by DDAVP-treated monocytes mediates von willebrand factor release from endothelial cells</title><author>Hashemi, S. ; Palmer, D. S. ; Aye, M. T. ; Ganz, P. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4077-15cd8c4ef468c5dfa9c763bb0912767226eb044442739b57ca37f08a9d76c7283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adenosine Diphosphate - metabolism</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Cytokines - metabolism</topic><topic>Deamino Arginine Vasopressin - pharmacology</topic><topic>Dioxolanes - pharmacology</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Epoprostenol - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Monocytes - drug effects</topic><topic>Monocytes - metabolism</topic><topic>Platelet Activating Factor - metabolism</topic><topic>Platelet Activating Factor - pharmacology</topic><topic>Prostaglandins - metabolism</topic><topic>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</topic><topic>von Willebrand Factor - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashemi, S.</creatorcontrib><creatorcontrib>Palmer, D. S.</creatorcontrib><creatorcontrib>Aye, M. T.</creatorcontrib><creatorcontrib>Ganz, P. R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashemi, S.</au><au>Palmer, D. S.</au><au>Aye, M. T.</au><au>Ganz, P. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet-activating factor secreted by DDAVP-treated monocytes mediates von willebrand factor release from endothelial cells</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J. Cell. Physiol</addtitle><date>1993-03</date><risdate>1993</risdate><volume>154</volume><issue>3</issue><spage>496</spage><epage>505</epage><pages>496-505</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><coden>JCLLAX</coden><abstract>We have previously shown that although DDAVP (1‐deamino‐8‐D‐arginine vasopressin), a synthetic analogue of the natural hormone arginine vasopressin, does not directly promote release of vWf from human umbilical vein endothelial cells (ECs), enhanced release does occur when ECs were exposed to either monocytes or to supernatants recovered from DDAVP‐treated monocytes. In the present study, we have found that exposure of monocytes to DDAVP did not increase secretion of interleukins (IL)‐1β, IL‐6, IL‐8, tumor necrosis factor (TNF‐α), growth factors G‐CSF (granulocyte‐), GM‐CSF (granulocyte, monocyte‐colony stimulating factor), prostaglandins (PG) E2, PGF2α, or PGI2 or purine nucleotides such as ATP and ADP. However, increased levels of platelet‐activating factor (PAF) were secreted by DDAVP‐treated monocytes in a time‐ and dose‐dependent manner that positively correlated with the enhancement in vWf release from ECs. Moreover, this effect could also be elicited when lipid extracts of these supernatants or purified PAF were added directly to ECs. This response could be inhibited with (±)‐trans‐2,5‐Bis(3,4,5‐trimethoxyphenyl)‐1,3‐dioxolane, a specific PAF receptor antagonist, when the ECs were exposed to supernatants from DDAVP‐treated monocytes or to pure PAF. The present data indicate that enhanced secretion of PAF from monocytes is one mechanism whereby DDAVP can provoke release of vWf from ECs. © 1993 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8436598</pmid><doi>10.1002/jcp.1041540307</doi><tpages>10</tpages></addata></record> |
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subjects | Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Biological and medical sciences Cells, Cultured Cytokines - metabolism Deamino Arginine Vasopressin - pharmacology Dioxolanes - pharmacology Endothelium, Vascular - metabolism Epoprostenol - metabolism Fundamental and applied biological sciences. Psychology Humans Kinetics Monocytes - drug effects Monocytes - metabolism Platelet Activating Factor - metabolism Platelet Activating Factor - pharmacology Prostaglandins - metabolism Vertebrates: blood, hematopoietic organs, reticuloendothelial system von Willebrand Factor - metabolism |
title | Platelet-activating factor secreted by DDAVP-treated monocytes mediates von willebrand factor release from endothelial cells |
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