Regulation of endothelin-1 action on the perfused rat liver
Endothelin-1 (ET-1) was found to be a very potent stimulus for contraction and glycogenolysis in the perfused rat liver. At 1 nM it caused a dramatic increase in portal pressure of 22.1 ± 2.7 cm water and enhanced the glucose output up to 3-fold. Extracellular Ca 2+ and protein kinase C were involve...
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| Veröffentlicht in: | FEBS letters 1993-03, Vol.318 (3), p.353-357 |
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| creator | Tran-Thi, Thuy-Anh Kawada, Norifumi Decker, Karl |
| description | Endothelin-1 (ET-1) was found to be a very potent stimulus for contraction and glycogenolysis in the perfused rat liver. At 1 nM it caused a dramatic increase in portal pressure of 22.1 ± 2.7 cm water and enhanced the glucose output up to 3-fold. Extracellular Ca
2+ and protein kinase C were involved in the signal transduction of ET-1. ET-1 action does not seem to be mediated by endogenous eicosanoids. The effects of ET-1 were significantly reduced in the presence of 1 μM Iloprost, a prostaglandin I
2 analogue, or by 100 μM sin-1, a nitric oxide donor. In cultured hepatocytes, glycogenolysis was also stimulated by ET-1 although to an extent too small to explain the high glucose output found in the perfused liver. |
| doi_str_mv | 10.1016/0014-5793(93)80544-5 |
| format | Article |
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2+ and protein kinase C were involved in the signal transduction of ET-1. ET-1 action does not seem to be mediated by endogenous eicosanoids. The effects of ET-1 were significantly reduced in the presence of 1 μM Iloprost, a prostaglandin I
2 analogue, or by 100 μM sin-1, a nitric oxide donor. In cultured hepatocytes, glycogenolysis was also stimulated by ET-1 although to an extent too small to explain the high glucose output found in the perfused liver.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(93)80544-5</identifier><identifier>PMID: 8440394</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Aminoacids, peptides. Hormones. Neuropeptides ; Analytical, structural and metabolic biochemistry ; Animals ; Bile - physiology ; Biological and medical sciences ; Calcium - pharmacology ; Calcium ion ; Cells, Cultured ; Eicosanoid ; Endothelins - pharmacology ; Epoprostenol - biosynthesis ; ET-1, endothelin-1 ; Fundamental and applied biological sciences. Psychology ; Glucose - metabolism ; Glycogen - metabolism ; Indomethacin - pharmacology ; Kinetics ; Liver - blood supply ; Liver - metabolism ; Male ; Nitric oxide ; Nitric Oxide - metabolism ; Nitric Oxide - pharmacology ; NO, nitric oxide ; Perfusion ; PG, prostaglandin ; Portal Pressure ; Protein kinase C ; Protein Kinase C - antagonists & inhibitors ; Proteins ; Rats ; Rats, Wistar ; sin-1, 3-morpholino-sydnoimine-N-ethylcarbamide ; SNP, sodium nitroprusside ; Vasoconstriction</subject><ispartof>FEBS letters, 1993-03, Vol.318 (3), p.353-357</ispartof><rights>1993</rights><rights>FEBS Letters 318 (1993) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5615-9e1f276314c8a77f035ae2f1885e864084cf7292024d4c4ae46791ee49ae298e3</citedby><cites>FETCH-LOGICAL-c5615-9e1f276314c8a77f035ae2f1885e864084cf7292024d4c4ae46791ee49ae298e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014579393805445$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4677060$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8440394$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tran-Thi, Thuy-Anh</creatorcontrib><creatorcontrib>Kawada, Norifumi</creatorcontrib><creatorcontrib>Decker, Karl</creatorcontrib><title>Regulation of endothelin-1 action on the perfused rat liver</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Endothelin-1 (ET-1) was found to be a very potent stimulus for contraction and glycogenolysis in the perfused rat liver. At 1 nM it caused a dramatic increase in portal pressure of 22.1 ± 2.7 cm water and enhanced the glucose output up to 3-fold. Extracellular Ca
2+ and protein kinase C were involved in the signal transduction of ET-1. ET-1 action does not seem to be mediated by endogenous eicosanoids. The effects of ET-1 were significantly reduced in the presence of 1 μM Iloprost, a prostaglandin I
2 analogue, or by 100 μM sin-1, a nitric oxide donor. In cultured hepatocytes, glycogenolysis was also stimulated by ET-1 although to an extent too small to explain the high glucose output found in the perfused liver.</description><subject>Aminoacids, peptides. Hormones. Neuropeptides</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Bile - physiology</subject><subject>Biological and medical sciences</subject><subject>Calcium - pharmacology</subject><subject>Calcium ion</subject><subject>Cells, Cultured</subject><subject>Eicosanoid</subject><subject>Endothelins - pharmacology</subject><subject>Epoprostenol - biosynthesis</subject><subject>ET-1, endothelin-1</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose - metabolism</subject><subject>Glycogen - metabolism</subject><subject>Indomethacin - pharmacology</subject><subject>Kinetics</subject><subject>Liver - blood supply</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide - pharmacology</subject><subject>NO, nitric oxide</subject><subject>Perfusion</subject><subject>PG, prostaglandin</subject><subject>Portal Pressure</subject><subject>Protein kinase C</subject><subject>Protein Kinase C - antagonists & inhibitors</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>sin-1, 3-morpholino-sydnoimine-N-ethylcarbamide</subject><subject>SNP, sodium nitroprusside</subject><subject>Vasoconstriction</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkN1KxDAQhYMouv68gUIvRPSimjRJkyAIurgqCILodYjpRCPddk1axbc3tcteihAIc-abk8lBaJ_gU4JJeYYxYTkXih4reiIxZ6laQxMiBc0pK-U6mqyQLbQd4ztOtSRqE21KxjBVbILOH-G1r03n2yZrXQZN1XZvUPsmJ5mxo9xkScoWEFwfocqC6bLaf0LYRRvO1BH2lvcOep5dP01v8_uHm7vp5X1ueUl4roC4QpSUMCuNEA5TbqBwREoOsmRYMutEoQpcsIpZZoCVQhEAphKmJNAddDT6LkL70UPs9NxHC3VtGmj7qAXnShFZJpCNoA1tjAGcXgQ_N-FbE6yHzPQQiB4C0en8ZqZ5GjtY-vcvc6hWQ8uQUv9w2TfRmtoF01gfV1haV-ASJ2w2Yl--hu9_Pa1n11fF0Bh0RX_VYZ-L0QhSqJ8ego7WQ2Oh8gFsp6vW__2hH4LmmOo</recordid><startdate>19930308</startdate><enddate>19930308</enddate><creator>Tran-Thi, Thuy-Anh</creator><creator>Kawada, Norifumi</creator><creator>Decker, Karl</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930308</creationdate><title>Regulation of endothelin-1 action on the perfused rat liver</title><author>Tran-Thi, Thuy-Anh ; Kawada, Norifumi ; Decker, Karl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5615-9e1f276314c8a77f035ae2f1885e864084cf7292024d4c4ae46791ee49ae298e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Aminoacids, peptides. Hormones. Neuropeptides</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Bile - physiology</topic><topic>Biological and medical sciences</topic><topic>Calcium - pharmacology</topic><topic>Calcium ion</topic><topic>Cells, Cultured</topic><topic>Eicosanoid</topic><topic>Endothelins - pharmacology</topic><topic>Epoprostenol - biosynthesis</topic><topic>ET-1, endothelin-1</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose - metabolism</topic><topic>Glycogen - metabolism</topic><topic>Indomethacin - pharmacology</topic><topic>Kinetics</topic><topic>Liver - blood supply</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide - pharmacology</topic><topic>NO, nitric oxide</topic><topic>Perfusion</topic><topic>PG, prostaglandin</topic><topic>Portal Pressure</topic><topic>Protein kinase C</topic><topic>Protein Kinase C - antagonists & inhibitors</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>sin-1, 3-morpholino-sydnoimine-N-ethylcarbamide</topic><topic>SNP, sodium nitroprusside</topic><topic>Vasoconstriction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tran-Thi, Thuy-Anh</creatorcontrib><creatorcontrib>Kawada, Norifumi</creatorcontrib><creatorcontrib>Decker, Karl</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tran-Thi, Thuy-Anh</au><au>Kawada, Norifumi</au><au>Decker, Karl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of endothelin-1 action on the perfused rat liver</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1993-03-08</date><risdate>1993</risdate><volume>318</volume><issue>3</issue><spage>353</spage><epage>357</epage><pages>353-357</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>Endothelin-1 (ET-1) was found to be a very potent stimulus for contraction and glycogenolysis in the perfused rat liver. At 1 nM it caused a dramatic increase in portal pressure of 22.1 ± 2.7 cm water and enhanced the glucose output up to 3-fold. Extracellular Ca
2+ and protein kinase C were involved in the signal transduction of ET-1. ET-1 action does not seem to be mediated by endogenous eicosanoids. The effects of ET-1 were significantly reduced in the presence of 1 μM Iloprost, a prostaglandin I
2 analogue, or by 100 μM sin-1, a nitric oxide donor. In cultured hepatocytes, glycogenolysis was also stimulated by ET-1 although to an extent too small to explain the high glucose output found in the perfused liver.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8440394</pmid><doi>10.1016/0014-5793(93)80544-5</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Bile - physiology Biological and medical sciences Calcium - pharmacology Calcium ion Cells, Cultured Eicosanoid Endothelins - pharmacology Epoprostenol - biosynthesis ET-1, endothelin-1 Fundamental and applied biological sciences. Psychology Glucose - metabolism Glycogen - metabolism Indomethacin - pharmacology Kinetics Liver - blood supply Liver - metabolism Male Nitric oxide Nitric Oxide - metabolism Nitric Oxide - pharmacology NO, nitric oxide Perfusion PG, prostaglandin Portal Pressure Protein kinase C Protein Kinase C - antagonists & inhibitors Proteins Rats Rats, Wistar sin-1, 3-morpholino-sydnoimine-N-ethylcarbamide SNP, sodium nitroprusside Vasoconstriction |
| title | Regulation of endothelin-1 action on the perfused rat liver |
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