Assembly of recombinant rotavirus proteins into virus-like particles and assessment of vaccine potential

Rotavirus structural proteins VP4, VP6 and VP7 from Bovine Rotavirus Strain C486 were cloned and expressed in a baculovirus expression system. Combinations of the proteins were assembled into a series of virus-like particles, and a murine model was used to determine the capacity of the recombinant p...

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Veröffentlicht in:	Vaccine 1993, Vol.11 (2), p.273-281
Hauptverfasser:	Redmond, M.J., Ijaz, M.K., Parker, M.D., Sabara, M.I., Dent, D., Gibbons, E., Babiuk, L.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn - immunology Antibodies, Viral - biosynthesis Antibodies, Viral - immunology Antibody Specificity Antigens, Viral Baculoviridae Biological and medical sciences Capsid - immunology Capsid - ultrastructure Capsid Proteins Cattle - microbiology Female Fundamental and applied biological sciences. Psychology Hemagglutinins, Viral - immunology Mice Microbiology Pregnancy proteins Recombinant Fusion Proteins - immunology Rotavirus Rotavirus - immunology Rotavirus Infections - prevention & control Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Attenuated - immunology Vaccines, Synthetic - immunology Viral Vaccines - immunology Virology virus-like particles
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