Influence of Cadmium on the Intestinal Uptake and Absorption of Calcium in the Rat
To determine the effects of cadmium on the intestinal absorption of calcium, everted gut sacs from rats orally dosed with 0, 0.05, 0.5 or 5.0 mg Cd daily for 3 weeks were placed in media containing 4 × 10-5m Ca. Tissue content of calcium after 1 hour incubation was approximately 1.5 times greater fo...
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| Veröffentlicht in: | The Journal of nutrition 1981-04, Vol.111 (4), p.631-638 |
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| container_title | The Journal of nutrition |
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| creator | Chertok, R.J. Sasser, L.B. Callaham, M.F. Jarboe, G.E. |
| description | To determine the effects of cadmium on the intestinal absorption of calcium, everted gut sacs from rats orally dosed with 0, 0.05, 0.5 or 5.0 mg Cd daily for 3 weeks were placed in media containing 4 × 10-5m Ca. Tissue content of calcium after 1 hour incubation was approximately 1.5 times greater for the 5-mg Cd dose. Serosal fluid content of calcium was decreased by the 0.5- and 5-mg Cd/day doses. In other experiments, gut sacs were incubated in bathing media containng 4 × 10-5 Ca and Cd in concentrations of 10-4 to 10-2m. Tissue and serosal fluid uptake of calcium decreased as Cd concentration increased. To determine the effects of cadmium on the accumulation of calcium against a concentration gradient, equimolar concentrations of Cd were placed in the mucosal and serosal fluids. Cadmium was added to the mucosal fluid. The accumulation of calcium was abolished by 1.5 × 10-4m Cd while at 10-6m Cd the accumulation was decreased to one-third the control value. The results indicate that acute or chronic exposure of the intestine to cadmium decreases the intestinal absorption of calcium.
cadmium calcium absorption |
| doi_str_mv | 10.1093/jn/111.4.631 |
| format | Article |
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cadmium calcium absorption</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/111.4.631</identifier><identifier>PMID: 7218036</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>absorption ; Animals ; cadmium ; Cadmium - pharmacology ; calcium ; Calcium - metabolism ; Dose-Response Relationship, Drug ; In Vitro Techniques ; Intestinal Absorption - drug effects ; intestine ; Kinetics ; Male ; Rats ; uptake</subject><ispartof>The Journal of nutrition, 1981-04, Vol.111 (4), p.631-638</ispartof><rights>1981 American Society for Nutrition.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-b1ae34848d26c50a186a1c9fc5f9910342f2f1157da05bf0ed81a906c09f6e183</citedby><cites>FETCH-LOGICAL-c421t-b1ae34848d26c50a186a1c9fc5f9910342f2f1157da05bf0ed81a906c09f6e183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7218036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chertok, R.J.</creatorcontrib><creatorcontrib>Sasser, L.B.</creatorcontrib><creatorcontrib>Callaham, M.F.</creatorcontrib><creatorcontrib>Jarboe, G.E.</creatorcontrib><title>Influence of Cadmium on the Intestinal Uptake and Absorption of Calcium in the Rat</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>To determine the effects of cadmium on the intestinal absorption of calcium, everted gut sacs from rats orally dosed with 0, 0.05, 0.5 or 5.0 mg Cd daily for 3 weeks were placed in media containing 4 × 10-5m Ca. Tissue content of calcium after 1 hour incubation was approximately 1.5 times greater for the 5-mg Cd dose. Serosal fluid content of calcium was decreased by the 0.5- and 5-mg Cd/day doses. In other experiments, gut sacs were incubated in bathing media containng 4 × 10-5 Ca and Cd in concentrations of 10-4 to 10-2m. Tissue and serosal fluid uptake of calcium decreased as Cd concentration increased. To determine the effects of cadmium on the accumulation of calcium against a concentration gradient, equimolar concentrations of Cd were placed in the mucosal and serosal fluids. Cadmium was added to the mucosal fluid. The accumulation of calcium was abolished by 1.5 × 10-4m Cd while at 10-6m Cd the accumulation was decreased to one-third the control value. The results indicate that acute or chronic exposure of the intestine to cadmium decreases the intestinal absorption of calcium.
cadmium calcium absorption</description><subject>absorption</subject><subject>Animals</subject><subject>cadmium</subject><subject>Cadmium - pharmacology</subject><subject>calcium</subject><subject>Calcium - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>In Vitro Techniques</subject><subject>Intestinal Absorption - drug effects</subject><subject>intestine</subject><subject>Kinetics</subject><subject>Male</subject><subject>Rats</subject><subject>uptake</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFr2zAUh8VY6dJut50GA596mpP3JEuRjiW0a6BQaJuzUGRpU2bLmWQX9t_XiUNPg550-H2_98T3CPmKMEdQbLGLC0ScV3PB8AOZIa-wFAjwkcwAKC0ZCvGJXOS8AwCslDwn50uKEpiYkcd19M3gonVF54uVqdswtEUXi_63K9axd7kP0TTFZt-bP64wsS6ut7lL-z6M0LHS2EMlTJVH038mZ9402X05vZdkc3vzvLor7x9-rlfX96WtKPblFo1jlaxkTYXlYFAKg1Z5y71SCKyinnpEvqwN8K0HV0s0CoQF5YVDyS7J1TR3n7q_w_hR3YZsXdOY6Loh6yXnSqJg74LIGUN6BH9MoE1dzsl5vU-hNemfRtAH13oX9ehaV3p0PeLfT3OHbevqN_gkd8y_Tbk3nTa_Ush68ySBKsphDMUUulHRS3BJZxsOd6hDcrbXdRf-v_UVSi6Ssg</recordid><startdate>198104</startdate><enddate>198104</enddate><creator>Chertok, R.J.</creator><creator>Sasser, L.B.</creator><creator>Callaham, M.F.</creator><creator>Jarboe, G.E.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>198104</creationdate><title>Influence of Cadmium on the Intestinal Uptake and Absorption of Calcium in the Rat</title><author>Chertok, R.J. ; Sasser, L.B. ; Callaham, M.F. ; Jarboe, G.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-b1ae34848d26c50a186a1c9fc5f9910342f2f1157da05bf0ed81a906c09f6e183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>absorption</topic><topic>Animals</topic><topic>cadmium</topic><topic>Cadmium - pharmacology</topic><topic>calcium</topic><topic>Calcium - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>In Vitro Techniques</topic><topic>Intestinal Absorption - drug effects</topic><topic>intestine</topic><topic>Kinetics</topic><topic>Male</topic><topic>Rats</topic><topic>uptake</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chertok, R.J.</creatorcontrib><creatorcontrib>Sasser, L.B.</creatorcontrib><creatorcontrib>Callaham, M.F.</creatorcontrib><creatorcontrib>Jarboe, G.E.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chertok, R.J.</au><au>Sasser, L.B.</au><au>Callaham, M.F.</au><au>Jarboe, G.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Cadmium on the Intestinal Uptake and Absorption of Calcium in the Rat</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1981-04</date><risdate>1981</risdate><volume>111</volume><issue>4</issue><spage>631</spage><epage>638</epage><pages>631-638</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><abstract>To determine the effects of cadmium on the intestinal absorption of calcium, everted gut sacs from rats orally dosed with 0, 0.05, 0.5 or 5.0 mg Cd daily for 3 weeks were placed in media containing 4 × 10-5m Ca. Tissue content of calcium after 1 hour incubation was approximately 1.5 times greater for the 5-mg Cd dose. Serosal fluid content of calcium was decreased by the 0.5- and 5-mg Cd/day doses. In other experiments, gut sacs were incubated in bathing media containng 4 × 10-5 Ca and Cd in concentrations of 10-4 to 10-2m. Tissue and serosal fluid uptake of calcium decreased as Cd concentration increased. To determine the effects of cadmium on the accumulation of calcium against a concentration gradient, equimolar concentrations of Cd were placed in the mucosal and serosal fluids. Cadmium was added to the mucosal fluid. The accumulation of calcium was abolished by 1.5 × 10-4m Cd while at 10-6m Cd the accumulation was decreased to one-third the control value. The results indicate that acute or chronic exposure of the intestine to cadmium decreases the intestinal absorption of calcium.
cadmium calcium absorption</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7218036</pmid><doi>10.1093/jn/111.4.631</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | absorption Animals cadmium Cadmium - pharmacology calcium Calcium - metabolism Dose-Response Relationship, Drug In Vitro Techniques Intestinal Absorption - drug effects intestine Kinetics Male Rats uptake |
| title | Influence of Cadmium on the Intestinal Uptake and Absorption of Calcium in the Rat |
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