Synthesis of Fatty Acid Amides of Catechol Metabolites that Exhibit Antiobesity Properties

A series of fatty acid amides of 3,4‐methylenedioxymethamphetamine (MDMA) catechol metabolites were synthesized in order to evaluate their biological activities. Upon administration, all synthesized compounds resulted in negative modulation of food intake in rats. The most active compounds have affi...

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Veröffentlicht in:	ChemMedChem 2010-10, Vol.5 (10), p.1781-1787
Hauptverfasser:	Almeida, Bruno, Joglar, Jesús, Luque Rojas, María Jesús, Decara, Juan Manuel, Bermúdez-Silva, Francisco Javier, Macias-González, Manuel, Fitó, Montserrat, Romero-Cuevas, Miguel, Farré, Magí, Covas, María Isabel, Rodríguez de Fonseca, Fernando, de la Torre, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - chemistry Amides - pharmacology Animals Anti-Obesity Agents - chemical synthesis Anti-Obesity Agents - chemistry Anti-Obesity Agents - pharmacology Catechols - chemistry Catechols - metabolism CB1 endocannabinoids Fatty Acids - chemistry Kinetics Male N-Methyl-3,4-methylenedioxyamphetamine - chemistry N-Methyl-3,4-methylenedioxyamphetamine - metabolism obesity PPAR alpha - chemistry PPAR alpha - metabolism PPAR-α Rats Rats, Wistar Receptor, Cannabinoid, CB1 - chemistry Receptor, Cannabinoid, CB1 - metabolism receptors
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