Protein:creatinine ratio in uncomplicated twin pregnancy
Objective Women with twin pregnancies may have higher rates of isolated proteinuria than do those with singletons. We compared protein-to-creatinine (P:C) ratios longitudinally through gestation in uncomplicated twin and singleton pregnancies. Study Design P:C ratios were compared at 3 times points...
Gespeichert in:
| Veröffentlicht in: | American journal of obstetrics and gynecology 2010-10, Vol.203 (4), p.381.e1-381.e4 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 381.e4 |
|---|---|
| container_issue | 4 |
| container_start_page | 381.e1 |
| container_title | American journal of obstetrics and gynecology |
| container_volume | 203 |
| creator | Smith, Nicole A., MD, MPH Lyons, Jennifer G., MPH McElrath, Thomas F., MD, PhD |
| description | Objective Women with twin pregnancies may have higher rates of isolated proteinuria than do those with singletons. We compared protein-to-creatinine (P:C) ratios longitudinally through gestation in uncomplicated twin and singleton pregnancies. Study Design P:C ratios were compared at 3 times points in 102 (51 twins, 51 singletons) healthy gravid patients who did not have preeclampsia develop, using linear and logistic regression techniques. Results P:C ratio increased significantly over gestation in all patients. This increase was significantly greater in twins than in singletons. The odds of P:C ratio >0.19 was 3.5 times higher in twins between 34 and 38 weeks. Conclusion Women with uncomplicated twin pregnancies have greater protein excretion as measured by P:C ratios than do those with singletons. In early pregnancy, protein excretion is similar, but it diverges significantly by the latter third trimester. We suggest that normal values for proteinuria in twins may differ from those in singletons, and warrant further evaluation. |
| doi_str_mv | 10.1016/j.ajog.2010.06.013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_755971778</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002937810007714</els_id><sourcerecordid>755971778</sourcerecordid><originalsourceid>FETCH-LOGICAL-c506t-7f1d0823ebdfcfddd60fa574c5d3fa510fccdc2a197bc2373a7c348e4bf6c6943</originalsourceid><addsrcrecordid>eNp9kU2LFDEQQIMo7uzqH_AgcxFPPeajO-mICLK4rrCwC-o5ZCqVJW1PMibdK_PvTTOjggdPqRSvqpJXhLxgdMMok2-GjR3S_YbTmqByQ5l4RFaMatXIXvaPyYpSyhstVH9GzksZlivX_Ck541RqpmW3Iv1dThOG-BYy2inEEHGda5DWIa7nCGm3HwPYCd16-llT-4z30UY4PCNPvB0LPj-dF-Tb1cevl9fNze2nz5cfbhroqJwa5ZmjPRe4dR68c05SbzvVQudEDRj1AA64ZVptgQslrALR9thuvQSpW3FBXh_77nP6MWOZzC4UwHG0EdNcjOo6rZhSfSX5kYScSsnozT6Hnc0Hw6hZhJnBLMLMIsxQaaqwWvTy1H7e7tD9KfltqAKvToAtYEef6-dD-csJwZXWsnLvjhxWGQ8BsykQMAK6kBEm41L4_zve_1MOY91GnfgdD1iGNOdYNRtmCjfUfFl2uWyW1UAp1opfcaaeyw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>755971778</pqid></control><display><type>article</type><title>Protein:creatinine ratio in uncomplicated twin pregnancy</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Smith, Nicole A., MD, MPH ; Lyons, Jennifer G., MPH ; McElrath, Thomas F., MD, PhD</creator><creatorcontrib>Smith, Nicole A., MD, MPH ; Lyons, Jennifer G., MPH ; McElrath, Thomas F., MD, PhD</creatorcontrib><description>Objective Women with twin pregnancies may have higher rates of isolated proteinuria than do those with singletons. We compared protein-to-creatinine (P:C) ratios longitudinally through gestation in uncomplicated twin and singleton pregnancies. Study Design P:C ratios were compared at 3 times points in 102 (51 twins, 51 singletons) healthy gravid patients who did not have preeclampsia develop, using linear and logistic regression techniques. Results P:C ratio increased significantly over gestation in all patients. This increase was significantly greater in twins than in singletons. The odds of P:C ratio >0.19 was 3.5 times higher in twins between 34 and 38 weeks. Conclusion Women with uncomplicated twin pregnancies have greater protein excretion as measured by P:C ratios than do those with singletons. In early pregnancy, protein excretion is similar, but it diverges significantly by the latter third trimester. We suggest that normal values for proteinuria in twins may differ from those in singletons, and warrant further evaluation.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2010.06.013</identifier><identifier>PMID: 20691965</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Biological and medical sciences ; Body Mass Index ; Creatinine - urine ; Female ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Logistic Models ; Medical sciences ; Obstetrics and Gynecology ; Pregnancy ; Pregnancy, Multiple ; Prospective Studies ; protein-to-creatinine ratio ; proteinuria ; Proteinuria - epidemiology ; Reproductive Techniques, Assisted ; Smoking - adverse effects ; twin ; Twins</subject><ispartof>American journal of obstetrics and gynecology, 2010-10, Vol.203 (4), p.381.e1-381.e4</ispartof><rights>Mosby, Inc.</rights><rights>2010 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-7f1d0823ebdfcfddd60fa574c5d3fa510fccdc2a197bc2373a7c348e4bf6c6943</citedby><cites>FETCH-LOGICAL-c506t-7f1d0823ebdfcfddd60fa574c5d3fa510fccdc2a197bc2373a7c348e4bf6c6943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2010.06.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23327996$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20691965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Nicole A., MD, MPH</creatorcontrib><creatorcontrib>Lyons, Jennifer G., MPH</creatorcontrib><creatorcontrib>McElrath, Thomas F., MD, PhD</creatorcontrib><title>Protein:creatinine ratio in uncomplicated twin pregnancy</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective Women with twin pregnancies may have higher rates of isolated proteinuria than do those with singletons. We compared protein-to-creatinine (P:C) ratios longitudinally through gestation in uncomplicated twin and singleton pregnancies. Study Design P:C ratios were compared at 3 times points in 102 (51 twins, 51 singletons) healthy gravid patients who did not have preeclampsia develop, using linear and logistic regression techniques. Results P:C ratio increased significantly over gestation in all patients. This increase was significantly greater in twins than in singletons. The odds of P:C ratio >0.19 was 3.5 times higher in twins between 34 and 38 weeks. Conclusion Women with uncomplicated twin pregnancies have greater protein excretion as measured by P:C ratios than do those with singletons. In early pregnancy, protein excretion is similar, but it diverges significantly by the latter third trimester. We suggest that normal values for proteinuria in twins may differ from those in singletons, and warrant further evaluation.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Creatinine - urine</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Medical sciences</subject><subject>Obstetrics and Gynecology</subject><subject>Pregnancy</subject><subject>Pregnancy, Multiple</subject><subject>Prospective Studies</subject><subject>protein-to-creatinine ratio</subject><subject>proteinuria</subject><subject>Proteinuria - epidemiology</subject><subject>Reproductive Techniques, Assisted</subject><subject>Smoking - adverse effects</subject><subject>twin</subject><subject>Twins</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQQIMo7uzqH_AgcxFPPeajO-mICLK4rrCwC-o5ZCqVJW1PMibdK_PvTTOjggdPqRSvqpJXhLxgdMMok2-GjR3S_YbTmqByQ5l4RFaMatXIXvaPyYpSyhstVH9GzksZlivX_Ck541RqpmW3Iv1dThOG-BYy2inEEHGda5DWIa7nCGm3HwPYCd16-llT-4z30UY4PCNPvB0LPj-dF-Tb1cevl9fNze2nz5cfbhroqJwa5ZmjPRe4dR68c05SbzvVQudEDRj1AA64ZVptgQslrALR9thuvQSpW3FBXh_77nP6MWOZzC4UwHG0EdNcjOo6rZhSfSX5kYScSsnozT6Hnc0Hw6hZhJnBLMLMIsxQaaqwWvTy1H7e7tD9KfltqAKvToAtYEef6-dD-csJwZXWsnLvjhxWGQ8BsykQMAK6kBEm41L4_zve_1MOY91GnfgdD1iGNOdYNRtmCjfUfFl2uWyW1UAp1opfcaaeyw</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Smith, Nicole A., MD, MPH</creator><creator>Lyons, Jennifer G., MPH</creator><creator>McElrath, Thomas F., MD, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101001</creationdate><title>Protein:creatinine ratio in uncomplicated twin pregnancy</title><author>Smith, Nicole A., MD, MPH ; Lyons, Jennifer G., MPH ; McElrath, Thomas F., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-7f1d0823ebdfcfddd60fa574c5d3fa510fccdc2a197bc2373a7c348e4bf6c6943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Creatinine - urine</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Medical sciences</topic><topic>Obstetrics and Gynecology</topic><topic>Pregnancy</topic><topic>Pregnancy, Multiple</topic><topic>Prospective Studies</topic><topic>protein-to-creatinine ratio</topic><topic>proteinuria</topic><topic>Proteinuria - epidemiology</topic><topic>Reproductive Techniques, Assisted</topic><topic>Smoking - adverse effects</topic><topic>twin</topic><topic>Twins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Nicole A., MD, MPH</creatorcontrib><creatorcontrib>Lyons, Jennifer G., MPH</creatorcontrib><creatorcontrib>McElrath, Thomas F., MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Nicole A., MD, MPH</au><au>Lyons, Jennifer G., MPH</au><au>McElrath, Thomas F., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein:creatinine ratio in uncomplicated twin pregnancy</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>203</volume><issue>4</issue><spage>381.e1</spage><epage>381.e4</epage><pages>381.e1-381.e4</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective Women with twin pregnancies may have higher rates of isolated proteinuria than do those with singletons. We compared protein-to-creatinine (P:C) ratios longitudinally through gestation in uncomplicated twin and singleton pregnancies. Study Design P:C ratios were compared at 3 times points in 102 (51 twins, 51 singletons) healthy gravid patients who did not have preeclampsia develop, using linear and logistic regression techniques. Results P:C ratio increased significantly over gestation in all patients. This increase was significantly greater in twins than in singletons. The odds of P:C ratio >0.19 was 3.5 times higher in twins between 34 and 38 weeks. Conclusion Women with uncomplicated twin pregnancies have greater protein excretion as measured by P:C ratios than do those with singletons. In early pregnancy, protein excretion is similar, but it diverges significantly by the latter third trimester. We suggest that normal values for proteinuria in twins may differ from those in singletons, and warrant further evaluation.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>20691965</pmid><doi>10.1016/j.ajog.2010.06.013</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 2010-10, Vol.203 (4), p.381.e1-381.e4 |
| issn | 0002-9378 1097-6868 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_755971778 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Biological and medical sciences Body Mass Index Creatinine - urine Female Gestational Age Gynecology. Andrology. Obstetrics Humans Logistic Models Medical sciences Obstetrics and Gynecology Pregnancy Pregnancy, Multiple Prospective Studies protein-to-creatinine ratio proteinuria Proteinuria - epidemiology Reproductive Techniques, Assisted Smoking - adverse effects twin Twins |
| title | Protein:creatinine ratio in uncomplicated twin pregnancy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T02%3A01%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protein:creatinine%20ratio%20in%20uncomplicated%20twin%20pregnancy&rft.jtitle=American%20journal%20of%20obstetrics%20and%20gynecology&rft.au=Smith,%20Nicole%20A.,%20MD,%20MPH&rft.date=2010-10-01&rft.volume=203&rft.issue=4&rft.spage=381.e1&rft.epage=381.e4&rft.pages=381.e1-381.e4&rft.issn=0002-9378&rft.eissn=1097-6868&rft.coden=AJOGAH&rft_id=info:doi/10.1016/j.ajog.2010.06.013&rft_dat=%3Cproquest_cross%3E755971778%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=755971778&rft_id=info:pmid/20691965&rft_els_id=S0002937810007714&rfr_iscdi=true |