Knowledge of Panton–Valentine leukocidin–associated Staphylococcus aureus infections among paediatric registrars in England
1 2 PVL gene carriage is relatively uncommon in the UK, 3 but the association of PVL-producing Staphylococcus aureus (PVL+S aureus) with severe disease led the UK Health Protection Agency to publish guidance on the recognition and management of PVL+S aureus infection. 4 We surveyed paediatric regist...
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| Veröffentlicht in: | Archives of disease in childhood 2010-10, Vol.95 (10), p.855-856 |
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| creator | Freeman, H R Hutchings, F A Marriage, S C |
| description | 1 2 PVL gene carriage is relatively uncommon in the UK, 3 but the association of PVL-producing Staphylococcus aureus (PVL+S aureus) with severe disease led the UK Health Protection Agency to publish guidance on the recognition and management of PVL+S aureus infection. 4 We surveyed paediatric registrars to assess knowledge of this organism and the published guidance. The Health Protection Agency guidance advises supportive care of patients with PVL+S aureus necrotising pneumonia with early referral to intensive care. [beta]-Lactam antibiotics are not recommended owing to concerns that they may increase toxin production at suboptimal tissue concentrations, whereas antibiotics that inhibit toxin production, such as clindamycin and linezolid, are recommended. |
| doi_str_mv | 10.1136/adc.2010.184655 |
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The Health Protection Agency guidance advises supportive care of patients with PVL+S aureus necrotising pneumonia with early referral to intensive care. [beta]-Lactam antibiotics are not recommended owing to concerns that they may increase toxin production at suboptimal tissue concentrations, whereas antibiotics that inhibit toxin production, such as clindamycin and linezolid, are recommended.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.2010.184655</identifier><identifier>PMID: 20656735</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Antibiotics ; Bacterial diseases ; Bacterial Toxins - biosynthesis ; Biological and medical sciences ; Care and treatment ; Causes of ; Child ; Childhood pneumonia ; Clinical Competence ; Diagnosis ; England ; Exotoxins - biosynthesis ; General aspects ; Guidance ; Human bacterial diseases ; Humans ; Infections ; Infectious diseases ; Leukocidins - biosynthesis ; Medical sciences ; Medical Staff, Hospital - standards ; Miscellaneous ; Patients ; Pediatricians ; Pneumonia ; Pneumonia in children ; Pneumonia, Staphylococcal - diagnosis ; Polls & surveys ; Practice guidelines (Medicine) ; Prevention and actions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Staphylococcus aureus - metabolism ; Staphylococcus aureus infections ; Surveys ; Toxins</subject><ispartof>Archives of disease in childhood, 2010-10, Vol.95 (10), p.855-856</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2010 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b465t-a64d48cff7802eda6b8cb981413c6f32a1326da15771f166a456fe04aa2cdf3e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://adc.bmj.com/content/95/10/855.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://adc.bmj.com/content/95/10/855.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3182,23551,27903,27904,77346,77377</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23288753$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20656735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freeman, H R</creatorcontrib><creatorcontrib>Hutchings, F A</creatorcontrib><creatorcontrib>Marriage, S C</creatorcontrib><title>Knowledge of Panton–Valentine leukocidin–associated Staphylococcus aureus infections among paediatric registrars in England</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>1 2 PVL gene carriage is relatively uncommon in the UK, 3 but the association of PVL-producing Staphylococcus aureus (PVL+S aureus) with severe disease led the UK Health Protection Agency to publish guidance on the recognition and management of PVL+S aureus infection. 4 We surveyed paediatric registrars to assess knowledge of this organism and the published guidance. The Health Protection Agency guidance advises supportive care of patients with PVL+S aureus necrotising pneumonia with early referral to intensive care. [beta]-Lactam antibiotics are not recommended owing to concerns that they may increase toxin production at suboptimal tissue concentrations, whereas antibiotics that inhibit toxin production, such as clindamycin and linezolid, are recommended.</description><subject>Antibiotics</subject><subject>Bacterial diseases</subject><subject>Bacterial Toxins - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Care and treatment</subject><subject>Causes of</subject><subject>Child</subject><subject>Childhood pneumonia</subject><subject>Clinical Competence</subject><subject>Diagnosis</subject><subject>England</subject><subject>Exotoxins - biosynthesis</subject><subject>General aspects</subject><subject>Guidance</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Leukocidins - biosynthesis</subject><subject>Medical sciences</subject><subject>Medical Staff, Hospital - standards</subject><subject>Miscellaneous</subject><subject>Patients</subject><subject>Pediatricians</subject><subject>Pneumonia</subject><subject>Pneumonia in children</subject><subject>Pneumonia, Staphylococcal - diagnosis</subject><subject>Polls & surveys</subject><subject>Practice guidelines (Medicine)</subject><subject>Prevention and actions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Staphylococcus aureus - metabolism</subject><subject>Staphylococcus aureus infections</subject><subject>Surveys</subject><subject>Toxins</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkcFu1DAQhiMEokvhzA1FQggJKa0dO45zbJeWIipKofRqzdrjkG3WXuxEtCd4h74hT4KjXVqJC6exx9_8-j1_lj2nZI9SJvbB6L2STDfJRVU9yGaUC1mUhPOH2YwQwopGSrmTPYlxSQgtpWSPs52SiErUrJplPz84_6NH02Lubf4J3ODd71-3l9CjGzqHeY_jlded6aY2xJjOMKDJvwyw_nbTe-21HmMOY8BUOmdRD513qbPyrs3XgCYNhE7nAdsuDgHChOVHru3BmafZIwt9xGfbupt9PT66mJ8Up2fv3s8PTotF-tdQgOCGS21tLUmJBsRC6kUjKadMC8tKoKwUBmhV19RSIYBXwiLhAKU2liHbzV5vdNfBfx8xDmrVRY198oB-jKquqqZOIjSRL_8hl34MLplTVJZSNKKiIlHFhmrTplTntHcDXg_a9z22qJL3-Zk6KDlvGtqQid_f8Dr4GANatQ7dCsKNokRNUaoUpZqiVJso08SLrY9xsUJzx__NLgGvtgBEDb0N4HQX7zmWwq4rdm81bR-v794hXKmkU1fq4-VcXXx-e04P2bk6TvybDb9YLf_r8g9I48Y3</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Freeman, H R</creator><creator>Hutchings, F A</creator><creator>Marriage, S C</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20101001</creationdate><title>Knowledge of Panton–Valentine leukocidin–associated Staphylococcus aureus infections among paediatric registrars in England</title><author>Freeman, H R ; Hutchings, F A ; Marriage, S C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b465t-a64d48cff7802eda6b8cb981413c6f32a1326da15771f166a456fe04aa2cdf3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antibiotics</topic><topic>Bacterial diseases</topic><topic>Bacterial Toxins - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Care and treatment</topic><topic>Causes of</topic><topic>Child</topic><topic>Childhood pneumonia</topic><topic>Clinical Competence</topic><topic>Diagnosis</topic><topic>England</topic><topic>Exotoxins - biosynthesis</topic><topic>General aspects</topic><topic>Guidance</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Leukocidins - biosynthesis</topic><topic>Medical sciences</topic><topic>Medical Staff, Hospital - standards</topic><topic>Miscellaneous</topic><topic>Patients</topic><topic>Pediatricians</topic><topic>Pneumonia</topic><topic>Pneumonia in children</topic><topic>Pneumonia, Staphylococcal - diagnosis</topic><topic>Polls & surveys</topic><topic>Practice guidelines (Medicine)</topic><topic>Prevention and actions</topic><topic>Public health. 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The Health Protection Agency guidance advises supportive care of patients with PVL+S aureus necrotising pneumonia with early referral to intensive care. [beta]-Lactam antibiotics are not recommended owing to concerns that they may increase toxin production at suboptimal tissue concentrations, whereas antibiotics that inhibit toxin production, such as clindamycin and linezolid, are recommended.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>20656735</pmid><doi>10.1136/adc.2010.184655</doi><tpages>2</tpages></addata></record> |
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| source | MEDLINE; BMJ Journals - NESLi2 |
| subjects | Antibiotics Bacterial diseases Bacterial Toxins - biosynthesis Biological and medical sciences Care and treatment Causes of Child Childhood pneumonia Clinical Competence Diagnosis England Exotoxins - biosynthesis General aspects Guidance Human bacterial diseases Humans Infections Infectious diseases Leukocidins - biosynthesis Medical sciences Medical Staff, Hospital - standards Miscellaneous Patients Pediatricians Pneumonia Pneumonia in children Pneumonia, Staphylococcal - diagnosis Polls & surveys Practice guidelines (Medicine) Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcus aureus - metabolism Staphylococcus aureus infections Surveys Toxins |
| title | Knowledge of Panton–Valentine leukocidin–associated Staphylococcus aureus infections among paediatric registrars in England |
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