Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini

Endoplasmic reticulum (ER) stress leads to accumulation of un- or misfolded proteins inside the ER and initiates the unfolded protein response (UPR). Several UPR components are physiologically involved in pancreatic development and are pathophysiologically activated during acute pancreatitis. Howeve...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2010-10, Vol.299 (4), p.G877-G886
Hauptverfasser:	Malo, A, Krüger, B, Seyhun, E, Schäfer, C, Hoffmann, R T, Göke, B, Kubisch, C H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylases - secretion Animals Apoptosis Apoptosis - drug effects Calcium Signaling - drug effects Cathepsin B - metabolism Cholagogues and Choleretics - pharmacology Dose-Response Relationship, Drug Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - physiology Enzyme Activation Gene expression Pancreas Pancreas - cytology Pancreas - drug effects Pancreas - secretion Phosphorylation Physiology Protein folding Proteins Rats Stress, Physiological Studies Taurochenodeoxycholic Acid - pharmacology Trypsin - metabolism
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