Involved field radiotherapy for locally advanced non-small cell lung cancer: Isolated mediastinal nodal relapse
Abstract The current standard of care for locally advanced inoperable non-small cell lung cancer is high dose radiotherapy with concurrent chemotherapy. We report on a patient with stage IIIA NSCLC treated with concurrent chemoradiotherapy on the primary tumor and the 18-fluorodeoxyglucose positron...
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| Veröffentlicht in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 2010-11, Vol.70 (2), p.218-220 |
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| container_title | Lung cancer (Amsterdam, Netherlands) |
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| creator | Vanneste, B.G.L Haas, R.L.M Bard, M.P.L Rijna, H Váldes Olmos, R.A Belderbos, J.S.A |
| description | Abstract The current standard of care for locally advanced inoperable non-small cell lung cancer is high dose radiotherapy with concurrent chemotherapy. We report on a patient with stage IIIA NSCLC treated with concurrent chemoradiotherapy on the primary tumor and the 18-fluorodeoxyglucose positron emission tomography (18 FDG-PET) positive hilar and mediastinal lymph nodes. Six months after treatment this patient developed a single isolated contralateral mediastinal nodal relapse outside but in the proximity of the irradiated target volume. This patient was successfully re-irradiated to this isolated nodal relapse after reconstruction of the dose given to the localisation of this regional recurrence. This case describes the clinical problem of a regional recurrence after involved field radiotherapy that occasionally occurs. A possible explanation for those regional recurrences is an under staging of extension of the disease because the time-interval between the staging18 FDG-PET-CT scan and the start of the irradiation was too long. If the time-interval is 4 weeks or more, we strongly recommend a new18 FDG-PET-CT because of the possibility of upstaging of the disease. |
| doi_str_mv | 10.1016/j.lungcan.2010.08.008 |
| format | Article |
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We report on a patient with stage IIIA NSCLC treated with concurrent chemoradiotherapy on the primary tumor and the 18-fluorodeoxyglucose positron emission tomography (18 FDG-PET) positive hilar and mediastinal lymph nodes. Six months after treatment this patient developed a single isolated contralateral mediastinal nodal relapse outside but in the proximity of the irradiated target volume. This patient was successfully re-irradiated to this isolated nodal relapse after reconstruction of the dose given to the localisation of this regional recurrence. This case describes the clinical problem of a regional recurrence after involved field radiotherapy that occasionally occurs. A possible explanation for those regional recurrences is an under staging of extension of the disease because the time-interval between the staging18 FDG-PET-CT scan and the start of the irradiation was too long. If the time-interval is 4 weeks or more, we strongly recommend a new18 FDG-PET-CT because of the possibility of upstaging of the disease.</description><identifier>ISSN: 0169-5002</identifier><identifier>EISSN: 1872-8332</identifier><identifier>DOI: 10.1016/j.lungcan.2010.08.008</identifier><identifier>PMID: 20832897</identifier><identifier>CODEN: LUCAE5</identifier><language>eng</language><publisher>Oxford: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Carcinoma, Non-Small-Cell Lung - diagnosis ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Non-Small-Cell Lung - physiopathology ; Carcinoma, Non-Small-Cell Lung - radiotherapy ; Chemotherapy, Adjuvant ; Clinical Protocols ; Disease Progression ; Disease-Free Survival ; Hematology, Oncology and Palliative Medicine ; Humans ; Incidental dose ; Intensity modulated radiotherapy ; Involved field irradiation ; Isolated nodal failure ; Lung Neoplasms - diagnosis ; Lung Neoplasms - drug therapy ; Lung Neoplasms - pathology ; Lung Neoplasms - physiopathology ; Lung Neoplasms - radiotherapy ; Lymph Nodes - diagnostic imaging ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Male ; Mediastinum - pathology ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Non-small cell lung cancer ; Pneumology ; Pulmonary/Respiratory ; Radiography ; Radionuclide Imaging ; Radiotherapy Dosage ; Re-irradiation ; Tumors ; Tumors of the respiratory system and mediastinum</subject><ispartof>Lung cancer (Amsterdam, Netherlands), 2010-11, Vol.70 (2), p.218-220</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2010 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-24b4781428fa1661cfc304fe970b29b2b7957da99933b850c69eacc42aee42f13</citedby><cites>FETCH-LOGICAL-c449t-24b4781428fa1661cfc304fe970b29b2b7957da99933b850c69eacc42aee42f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0169500210003879$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23309657$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20832897$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vanneste, B.G.L</creatorcontrib><creatorcontrib>Haas, R.L.M</creatorcontrib><creatorcontrib>Bard, M.P.L</creatorcontrib><creatorcontrib>Rijna, H</creatorcontrib><creatorcontrib>Váldes Olmos, R.A</creatorcontrib><creatorcontrib>Belderbos, J.S.A</creatorcontrib><title>Involved field radiotherapy for locally advanced non-small cell lung cancer: Isolated mediastinal nodal relapse</title><title>Lung cancer (Amsterdam, Netherlands)</title><addtitle>Lung Cancer</addtitle><description>Abstract The current standard of care for locally advanced inoperable non-small cell lung cancer is high dose radiotherapy with concurrent chemotherapy. We report on a patient with stage IIIA NSCLC treated with concurrent chemoradiotherapy on the primary tumor and the 18-fluorodeoxyglucose positron emission tomography (18 FDG-PET) positive hilar and mediastinal lymph nodes. Six months after treatment this patient developed a single isolated contralateral mediastinal nodal relapse outside but in the proximity of the irradiated target volume. This patient was successfully re-irradiated to this isolated nodal relapse after reconstruction of the dose given to the localisation of this regional recurrence. This case describes the clinical problem of a regional recurrence after involved field radiotherapy that occasionally occurs. A possible explanation for those regional recurrences is an under staging of extension of the disease because the time-interval between the staging18 FDG-PET-CT scan and the start of the irradiation was too long. If the time-interval is 4 weeks or more, we strongly recommend a new18 FDG-PET-CT because of the possibility of upstaging of the disease.</description><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnosis</subject><subject>Carcinoma, Non-Small-Cell Lung - drug therapy</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - physiopathology</subject><subject>Carcinoma, Non-Small-Cell Lung - radiotherapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Clinical Protocols</subject><subject>Disease Progression</subject><subject>Disease-Free Survival</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Incidental dose</subject><subject>Intensity modulated radiotherapy</subject><subject>Involved field irradiation</subject><subject>Isolated nodal failure</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - physiopathology</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>Lymph Nodes - diagnostic imaging</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Mediastinum - pathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>Non-small cell lung cancer</subject><subject>Pneumology</subject><subject>Pulmonary/Respiratory</subject><subject>Radiography</subject><subject>Radionuclide Imaging</subject><subject>Radiotherapy Dosage</subject><subject>Re-irradiation</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0169-5002</issn><issn>1872-8332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2P0zAQQC0EYsvCTwDlgjiljD-S2BxAaMVCpZU4AGfLcSbg4sbFTiv13zNRyyJx4TKWxm_G42cz9pzDmgNvX2_X8TB9925aC6Ac6DWAfsBWXHei1lKKh2xFnKkbAHHFnpSyBeAdB_OYXQnQUmjTrVjaTMcUjzhUY8A4VNkNIc0_MLv9qRpTrmLyLsZT5YajmzxxU5rqsqNc5ZHCMkXll638ptqUFN1M0A6H4MocJhepYKCYMbp9wafs0ehiwWeX9Zp9u_3w9eZTfff54-bm_V3tlTJzLVSvOs2V0KPjbcv96CWoEU0HvTC96DvTdIMzxkjZ6wZ8a9B5r4RDVGLk8pq9Ovfd5_TrgGW2u1CWgd2E6VBs1zTUSylJZHMmfU6lZBztPoedyyfLwS6q7dZeVNtFtQVtSTXVvbiccOjpuvdVf9wS8PICuEIOx0ySQvnLSQmmbRbu3ZlD8nEMmG3xARfXIaOf7ZDCf0d5-08HH8MU6NCfeMKyTYdMD1Est0VYsF-Wf7F8Cw4AUndG_gZeY7VQ</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Vanneste, B.G.L</creator><creator>Haas, R.L.M</creator><creator>Bard, M.P.L</creator><creator>Rijna, H</creator><creator>Váldes Olmos, R.A</creator><creator>Belderbos, J.S.A</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101101</creationdate><title>Involved field radiotherapy for locally advanced non-small cell lung cancer: Isolated mediastinal nodal relapse</title><author>Vanneste, B.G.L ; Haas, R.L.M ; Bard, M.P.L ; Rijna, H ; Váldes Olmos, R.A ; Belderbos, J.S.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-24b4781428fa1661cfc304fe970b29b2b7957da99933b850c69eacc42aee42f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnosis</topic><topic>Carcinoma, Non-Small-Cell Lung - drug therapy</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Non-Small-Cell Lung - physiopathology</topic><topic>Carcinoma, Non-Small-Cell Lung - radiotherapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Clinical Protocols</topic><topic>Disease Progression</topic><topic>Disease-Free Survival</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Incidental dose</topic><topic>Intensity modulated radiotherapy</topic><topic>Involved field irradiation</topic><topic>Isolated nodal failure</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - physiopathology</topic><topic>Lung Neoplasms - radiotherapy</topic><topic>Lymph Nodes - diagnostic imaging</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Mediastinum - pathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasm Staging</topic><topic>Non-small cell lung cancer</topic><topic>Pneumology</topic><topic>Pulmonary/Respiratory</topic><topic>Radiography</topic><topic>Radionuclide Imaging</topic><topic>Radiotherapy Dosage</topic><topic>Re-irradiation</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vanneste, B.G.L</creatorcontrib><creatorcontrib>Haas, R.L.M</creatorcontrib><creatorcontrib>Bard, M.P.L</creatorcontrib><creatorcontrib>Rijna, H</creatorcontrib><creatorcontrib>Váldes Olmos, R.A</creatorcontrib><creatorcontrib>Belderbos, J.S.A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vanneste, B.G.L</au><au>Haas, R.L.M</au><au>Bard, M.P.L</au><au>Rijna, H</au><au>Váldes Olmos, R.A</au><au>Belderbos, J.S.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involved field radiotherapy for locally advanced non-small cell lung cancer: Isolated mediastinal nodal relapse</atitle><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle><addtitle>Lung Cancer</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>70</volume><issue>2</issue><spage>218</spage><epage>220</epage><pages>218-220</pages><issn>0169-5002</issn><eissn>1872-8332</eissn><coden>LUCAE5</coden><abstract>Abstract The current standard of care for locally advanced inoperable non-small cell lung cancer is high dose radiotherapy with concurrent chemotherapy. We report on a patient with stage IIIA NSCLC treated with concurrent chemoradiotherapy on the primary tumor and the 18-fluorodeoxyglucose positron emission tomography (18 FDG-PET) positive hilar and mediastinal lymph nodes. Six months after treatment this patient developed a single isolated contralateral mediastinal nodal relapse outside but in the proximity of the irradiated target volume. This patient was successfully re-irradiated to this isolated nodal relapse after reconstruction of the dose given to the localisation of this regional recurrence. This case describes the clinical problem of a regional recurrence after involved field radiotherapy that occasionally occurs. A possible explanation for those regional recurrences is an under staging of extension of the disease because the time-interval between the staging18 FDG-PET-CT scan and the start of the irradiation was too long. If the time-interval is 4 weeks or more, we strongly recommend a new18 FDG-PET-CT because of the possibility of upstaging of the disease.</abstract><cop>Oxford</cop><pub>Elsevier Ireland Ltd</pub><pmid>20832897</pmid><doi>10.1016/j.lungcan.2010.08.008</doi><tpages>3</tpages></addata></record> |
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| ispartof | Lung cancer (Amsterdam, Netherlands), 2010-11, Vol.70 (2), p.218-220 |
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| subjects | Biological and medical sciences Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - physiopathology Carcinoma, Non-Small-Cell Lung - radiotherapy Chemotherapy, Adjuvant Clinical Protocols Disease Progression Disease-Free Survival Hematology, Oncology and Palliative Medicine Humans Incidental dose Intensity modulated radiotherapy Involved field irradiation Isolated nodal failure Lung Neoplasms - diagnosis Lung Neoplasms - drug therapy Lung Neoplasms - pathology Lung Neoplasms - physiopathology Lung Neoplasms - radiotherapy Lymph Nodes - diagnostic imaging Lymph Nodes - pathology Lymphatic Metastasis Male Mediastinum - pathology Medical sciences Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Non-small cell lung cancer Pneumology Pulmonary/Respiratory Radiography Radionuclide Imaging Radiotherapy Dosage Re-irradiation Tumors Tumors of the respiratory system and mediastinum |
| title | Involved field radiotherapy for locally advanced non-small cell lung cancer: Isolated mediastinal nodal relapse |
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