Colony-stimulating factor-1 in primary ascites of ovarian cancer is a significant predictor of survival
Objective: Our purpose was to determine whether the concentration of colony-stimulating factor in ascites of ovarian carcinoma is a prognostic factor for survival. Study Design: Forty-four ascites samples from patients undergoing primary surgery for ovarian carcinoma were measured for colony-stimula...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1993-02, Vol.168 (2), p.520-527 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Price, Fredric V. Chambers, Setsuko K. Chambers, Joseph T. Carcangiu, Maria Luisa Schwartz, Peter E. Kohorn, Ernest I. Stanley, E. Richard Kacinski, Barry M. |
| description | Objective: Our purpose was to determine whether the concentration of colony-stimulating factor in ascites of ovarian carcinoma is a prognostic factor for survival.
Study Design: Forty-four ascites samples from patients undergoing primary surgery for ovarian carcinoma were measured for colony-stimulating factor-1 by radioimmunoassay. Retrospective analysis of clinical data allowed comparison of accepted prognostic factors to ascites colony-stimulating factor-1 concentration for impact on survival by means of life-table analysis (Kaplan-Meier) by the Wilcoxon test and the Cox regression methods.
Results: In patients with advanced disease (International Federation of Gynecology and Obstetrics stages III and IV,
n = 37) ascites colony-stimulating factor-1 concentration levels below a crtical cutoff of 8.59 ng/ml were associated with longer overall survival (
p < 0.05) and were a better predictor of survival than any other prognostic factor except zero residual disease after cytoreduction. International Federation of Gynecology and Obstetrics stage, tumor histologic type, malignant cells in fluid, grade of tumor, age, and performance status at presentation were not predictive of outcome.
Conclusion: Colony-stimulating factor-1 in ascites may be an independent indicator of prognosis in patients with epithelial ovarian cancer. |
| doi_str_mv | 10.1016/0002-9378(93)90485-2 |
| format | Article |
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Study Design: Forty-four ascites samples from patients undergoing primary surgery for ovarian carcinoma were measured for colony-stimulating factor-1 by radioimmunoassay. Retrospective analysis of clinical data allowed comparison of accepted prognostic factors to ascites colony-stimulating factor-1 concentration for impact on survival by means of life-table analysis (Kaplan-Meier) by the Wilcoxon test and the Cox regression methods.
Results: In patients with advanced disease (International Federation of Gynecology and Obstetrics stages III and IV,
n = 37) ascites colony-stimulating factor-1 concentration levels below a crtical cutoff of 8.59 ng/ml were associated with longer overall survival (
p < 0.05) and were a better predictor of survival than any other prognostic factor except zero residual disease after cytoreduction. International Federation of Gynecology and Obstetrics stage, tumor histologic type, malignant cells in fluid, grade of tumor, age, and performance status at presentation were not predictive of outcome.
Conclusion: Colony-stimulating factor-1 in ascites may be an independent indicator of prognosis in patients with epithelial ovarian cancer.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(93)90485-2</identifier><identifier>PMID: 8438921</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Adult ; Aging - physiology ; ascites ; Ascites - etiology ; Ascites - metabolism ; Ascites - mortality ; Biological and medical sciences ; Colony-Stimulating Factors - metabolism ; cytokines ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Macrophage colony-stimulating factor ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Osmolar Concentration ; ovarian carcinoma ; Ovarian Neoplasms - complications ; Ovarian Neoplasms - metabolism ; Ovarian Neoplasms - surgery ; Prognosis ; Regression Analysis ; Survival Analysis ; Tumors</subject><ispartof>American journal of obstetrics and gynecology, 1993-02, Vol.168 (2), p.520-527</ispartof><rights>1993 Mosby</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-2ad45a5aff9bd762f92cf3f46b674eb28e36db5fda187bacb25d80ccce80fb133</citedby><cites>FETCH-LOGICAL-c301t-2ad45a5aff9bd762f92cf3f46b674eb28e36db5fda187bacb25d80ccce80fb133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0002937893904852$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4678038$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8438921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Price, Fredric V.</creatorcontrib><creatorcontrib>Chambers, Setsuko K.</creatorcontrib><creatorcontrib>Chambers, Joseph T.</creatorcontrib><creatorcontrib>Carcangiu, Maria Luisa</creatorcontrib><creatorcontrib>Schwartz, Peter E.</creatorcontrib><creatorcontrib>Kohorn, Ernest I.</creatorcontrib><creatorcontrib>Stanley, E. Richard</creatorcontrib><creatorcontrib>Kacinski, Barry M.</creatorcontrib><title>Colony-stimulating factor-1 in primary ascites of ovarian cancer is a significant predictor of survival</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective: Our purpose was to determine whether the concentration of colony-stimulating factor in ascites of ovarian carcinoma is a prognostic factor for survival.
Study Design: Forty-four ascites samples from patients undergoing primary surgery for ovarian carcinoma were measured for colony-stimulating factor-1 by radioimmunoassay. Retrospective analysis of clinical data allowed comparison of accepted prognostic factors to ascites colony-stimulating factor-1 concentration for impact on survival by means of life-table analysis (Kaplan-Meier) by the Wilcoxon test and the Cox regression methods.
Results: In patients with advanced disease (International Federation of Gynecology and Obstetrics stages III and IV,
n = 37) ascites colony-stimulating factor-1 concentration levels below a crtical cutoff of 8.59 ng/ml were associated with longer overall survival (
p < 0.05) and were a better predictor of survival than any other prognostic factor except zero residual disease after cytoreduction. International Federation of Gynecology and Obstetrics stage, tumor histologic type, malignant cells in fluid, grade of tumor, age, and performance status at presentation were not predictive of outcome.
Conclusion: Colony-stimulating factor-1 in ascites may be an independent indicator of prognosis in patients with epithelial ovarian cancer.</description><subject>Adult</subject><subject>Aging - physiology</subject><subject>ascites</subject><subject>Ascites - etiology</subject><subject>Ascites - metabolism</subject><subject>Ascites - mortality</subject><subject>Biological and medical sciences</subject><subject>Colony-Stimulating Factors - metabolism</subject><subject>cytokines</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Macrophage colony-stimulating factor</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Staging</subject><subject>Osmolar Concentration</subject><subject>ovarian carcinoma</subject><subject>Ovarian Neoplasms - complications</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovarian Neoplasms - surgery</subject><subject>Prognosis</subject><subject>Regression Analysis</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtr3DAURkVpSKdp_0ELWoTQLJzq4Ye0KZShTQuBbJK1uNZjuMVjJZI9kH8fOWNm2Y2EdM_3IR1CvnB2wxlvvzPGRKVlp75pea1ZrZpKvCMbznRXtapV78nmhHwgH3P-txyFFufkXNVSacE3ZLeNQxxfqjzhfh5gwnFHA9gppopTHOlTwj2kFwrZ4uQzjYHGAySEkVoYrU8UMwWacTdiwHI1lYh3uDQscJ7TAQ8wfCJnAYbsP6_7BXn8_eth-6e6u7_9u_15V1nJ-FQJcHUDDYSge9e1Imhhgwx127dd7XuhvGxd3wQHXHU92F40TjFrrVcs9FzKC3J17H1K8Xn2eTJ7zNYPA4w-ztl0TaMbybsC1kfQpphz8sGsXzWcmcWvWWyZRV5ZzJtfI0rs69o_93vvTqFVaJlfrvNiDIaQiiTMJ6xuO8WkKtiPI-aLiwP6ZIpfX3w6TN5OxkX8_zteAa_kmQA</recordid><startdate>199302</startdate><enddate>199302</enddate><creator>Price, Fredric V.</creator><creator>Chambers, Setsuko K.</creator><creator>Chambers, Joseph T.</creator><creator>Carcangiu, Maria Luisa</creator><creator>Schwartz, Peter E.</creator><creator>Kohorn, Ernest I.</creator><creator>Stanley, E. Richard</creator><creator>Kacinski, Barry M.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199302</creationdate><title>Colony-stimulating factor-1 in primary ascites of ovarian cancer is a significant predictor of survival</title><author>Price, Fredric V. ; Chambers, Setsuko K. ; Chambers, Joseph T. ; Carcangiu, Maria Luisa ; Schwartz, Peter E. ; Kohorn, Ernest I. ; Stanley, E. Richard ; Kacinski, Barry M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-2ad45a5aff9bd762f92cf3f46b674eb28e36db5fda187bacb25d80ccce80fb133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Aging - physiology</topic><topic>ascites</topic><topic>Ascites - etiology</topic><topic>Ascites - metabolism</topic><topic>Ascites - mortality</topic><topic>Biological and medical sciences</topic><topic>Colony-Stimulating Factors - metabolism</topic><topic>cytokines</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Macrophage colony-stimulating factor</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Staging</topic><topic>Osmolar Concentration</topic><topic>ovarian carcinoma</topic><topic>Ovarian Neoplasms - complications</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Ovarian Neoplasms - surgery</topic><topic>Prognosis</topic><topic>Regression Analysis</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Price, Fredric V.</creatorcontrib><creatorcontrib>Chambers, Setsuko K.</creatorcontrib><creatorcontrib>Chambers, Joseph T.</creatorcontrib><creatorcontrib>Carcangiu, Maria Luisa</creatorcontrib><creatorcontrib>Schwartz, Peter E.</creatorcontrib><creatorcontrib>Kohorn, Ernest I.</creatorcontrib><creatorcontrib>Stanley, E. Richard</creatorcontrib><creatorcontrib>Kacinski, Barry M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Price, Fredric V.</au><au>Chambers, Setsuko K.</au><au>Chambers, Joseph T.</au><au>Carcangiu, Maria Luisa</au><au>Schwartz, Peter E.</au><au>Kohorn, Ernest I.</au><au>Stanley, E. Richard</au><au>Kacinski, Barry M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colony-stimulating factor-1 in primary ascites of ovarian cancer is a significant predictor of survival</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1993-02</date><risdate>1993</risdate><volume>168</volume><issue>2</issue><spage>520</spage><epage>527</epage><pages>520-527</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective: Our purpose was to determine whether the concentration of colony-stimulating factor in ascites of ovarian carcinoma is a prognostic factor for survival.
Study Design: Forty-four ascites samples from patients undergoing primary surgery for ovarian carcinoma were measured for colony-stimulating factor-1 by radioimmunoassay. Retrospective analysis of clinical data allowed comparison of accepted prognostic factors to ascites colony-stimulating factor-1 concentration for impact on survival by means of life-table analysis (Kaplan-Meier) by the Wilcoxon test and the Cox regression methods.
Results: In patients with advanced disease (International Federation of Gynecology and Obstetrics stages III and IV,
n = 37) ascites colony-stimulating factor-1 concentration levels below a crtical cutoff of 8.59 ng/ml were associated with longer overall survival (
p < 0.05) and were a better predictor of survival than any other prognostic factor except zero residual disease after cytoreduction. International Federation of Gynecology and Obstetrics stage, tumor histologic type, malignant cells in fluid, grade of tumor, age, and performance status at presentation were not predictive of outcome.
Conclusion: Colony-stimulating factor-1 in ascites may be an independent indicator of prognosis in patients with epithelial ovarian cancer.</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>8438921</pmid><doi>10.1016/0002-9378(93)90485-2</doi><tpages>8</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1993-02, Vol.168 (2), p.520-527 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aging - physiology ascites Ascites - etiology Ascites - metabolism Ascites - mortality Biological and medical sciences Colony-Stimulating Factors - metabolism cytokines Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Macrophage colony-stimulating factor Medical sciences Middle Aged Multivariate Analysis Neoplasm Staging Osmolar Concentration ovarian carcinoma Ovarian Neoplasms - complications Ovarian Neoplasms - metabolism Ovarian Neoplasms - surgery Prognosis Regression Analysis Survival Analysis Tumors |
| title | Colony-stimulating factor-1 in primary ascites of ovarian cancer is a significant predictor of survival |
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