HIV infection and severe malnutrition : a clinical and epidemiological study in Burkina Faso
To define a clinical profile indicative of HIV infection in a population of severely malnourished children in Burkina Faso. A total of 433 children (average age, 19 months) were recruited at the Sanou Souro National Hospital, Bobo Dioulasso, Burkina Faso. Sixty-three per cent presented with marasmus...
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| Veröffentlicht in: | AIDS (London) 1993, Vol.7 (1), p.103-108 |
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| creator | PRAZUCK, T TALL, F LAFAIX, C NACRO, B ROCHEREAU, A TRAORE, A SANOU, T MALKIN, J.-E APAIRE-MARCHAIS, V MASSON, D DUBLANCHET, A |
| description | To define a clinical profile indicative of HIV infection in a population of severely malnourished children in Burkina Faso. A total of 433 children (average age, 19 months) were recruited at the Sanou Souro National Hospital, Bobo Dioulasso, Burkina Faso.
Sixty-three per cent presented with marasmus, 13% with kwashiorkor and 24% with both forms of malnutrition. The prevalence of HIV infection in children aged over 12 months was 13.8%, with a marked predominance of HIV-1 (95.8%). Mother-to-child transmission was proven in 77% of the cases; in 10% of the observed paediatric AIDS cases, transmission may have occurred through multi-injections with contaminated equipment. Marasmus was the form of malnutrition most frequently associated with HIV (P < 0.001); its severity was exacerbated by HIV infection. Adenopathy (P < 0.0001), oral candidiasis (P < 0.0006), skin disorders (P < 0.01) and hepatomegaly (P = 0.01) appeared to be significantly related to HIV infection. Discriminant analysis revealed that the presence of adenopathies was the strongest indicator symptom of HIV infection. Multivariate analysis revealed that a clinical profile of marasmus, adenopathies and oral candidiasis (specificity, 82%) was indicative of HIV infection in this population. The short-term clinical prognosis was poor and usually led to the death of the child when seropositive (P < 0.001).
Among children exhibiting severe malnutrition, HIV-positive children are distinguished by a high horizontal transmission rate, a high specific clinical profile and a very poor prognosis. |
| doi_str_mv | 10.1097/00002030-199301000-00016 |
| format | Article |
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Sixty-three per cent presented with marasmus, 13% with kwashiorkor and 24% with both forms of malnutrition. The prevalence of HIV infection in children aged over 12 months was 13.8%, with a marked predominance of HIV-1 (95.8%). Mother-to-child transmission was proven in 77% of the cases; in 10% of the observed paediatric AIDS cases, transmission may have occurred through multi-injections with contaminated equipment. Marasmus was the form of malnutrition most frequently associated with HIV (P < 0.001); its severity was exacerbated by HIV infection. Adenopathy (P < 0.0001), oral candidiasis (P < 0.0006), skin disorders (P < 0.01) and hepatomegaly (P = 0.01) appeared to be significantly related to HIV infection. Discriminant analysis revealed that the presence of adenopathies was the strongest indicator symptom of HIV infection. Multivariate analysis revealed that a clinical profile of marasmus, adenopathies and oral candidiasis (specificity, 82%) was indicative of HIV infection in this population. The short-term clinical prognosis was poor and usually led to the death of the child when seropositive (P < 0.001).
Among children exhibiting severe malnutrition, HIV-positive children are distinguished by a high horizontal transmission rate, a high specific clinical profile and a very poor prognosis.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/00002030-199301000-00016</identifier><identifier>PMID: 8442899</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>AIDS/HIV ; Biological and medical sciences ; Burkina Faso - epidemiology ; Child, Preschool ; Female ; HIV Infections - complications ; HIV Infections - epidemiology ; HIV Infections - transmission ; HIV-1 ; human immunodeficiency virus ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infant ; Kwashiorkor - complications ; Male ; Medical sciences ; Multivariate Analysis ; Nutrition Disorders - complications ; Population ; Prognosis ; Protein-Energy Malnutrition - complications</subject><ispartof>AIDS (London), 1993, Vol.7 (1), p.103-108</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4677523$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8442899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PRAZUCK, T</creatorcontrib><creatorcontrib>TALL, F</creatorcontrib><creatorcontrib>LAFAIX, C</creatorcontrib><creatorcontrib>NACRO, B</creatorcontrib><creatorcontrib>ROCHEREAU, A</creatorcontrib><creatorcontrib>TRAORE, A</creatorcontrib><creatorcontrib>SANOU, T</creatorcontrib><creatorcontrib>MALKIN, J.-E</creatorcontrib><creatorcontrib>APAIRE-MARCHAIS, V</creatorcontrib><creatorcontrib>MASSON, D</creatorcontrib><creatorcontrib>DUBLANCHET, A</creatorcontrib><title>HIV infection and severe malnutrition : a clinical and epidemiological study in Burkina Faso</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>To define a clinical profile indicative of HIV infection in a population of severely malnourished children in Burkina Faso. A total of 433 children (average age, 19 months) were recruited at the Sanou Souro National Hospital, Bobo Dioulasso, Burkina Faso.
Sixty-three per cent presented with marasmus, 13% with kwashiorkor and 24% with both forms of malnutrition. The prevalence of HIV infection in children aged over 12 months was 13.8%, with a marked predominance of HIV-1 (95.8%). Mother-to-child transmission was proven in 77% of the cases; in 10% of the observed paediatric AIDS cases, transmission may have occurred through multi-injections with contaminated equipment. Marasmus was the form of malnutrition most frequently associated with HIV (P < 0.001); its severity was exacerbated by HIV infection. Adenopathy (P < 0.0001), oral candidiasis (P < 0.0006), skin disorders (P < 0.01) and hepatomegaly (P = 0.01) appeared to be significantly related to HIV infection. Discriminant analysis revealed that the presence of adenopathies was the strongest indicator symptom of HIV infection. Multivariate analysis revealed that a clinical profile of marasmus, adenopathies and oral candidiasis (specificity, 82%) was indicative of HIV infection in this population. The short-term clinical prognosis was poor and usually led to the death of the child when seropositive (P < 0.001).
Among children exhibiting severe malnutrition, HIV-positive children are distinguished by a high horizontal transmission rate, a high specific clinical profile and a very poor prognosis.</description><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Burkina Faso - epidemiology</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - transmission</subject><subject>HIV-1</subject><subject>human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Kwashiorkor - complications</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Nutrition Disorders - complications</subject><subject>Population</subject><subject>Prognosis</subject><subject>Protein-Energy Malnutrition - complications</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLAzEQx4MotVY_gpCDeFvNc5N402K1UPCinoQlzUOi-6jJrtBvb2xrrwbCMDO_eTB_ACBGVxgpcY3yI4iiAitFEc5ekT8uD8AYM0ELzgU-BGNESlUoKtAxOEnpIyMcSTkCI8kYkUqNwdvj_BWG1jvTh66FurUwuW8XHWx03Q59DJv4DdTQ1KENRtcbyK2CdU3o6u59E0v9YNe5Ebwb4mdoNZzp1J2CI6_r5M52dgJeZvfP08di8fQwn94uCkMo6guDCM8LcW-wp4xqypBXzHq8tMuldtmUkgjCmLWWeKk5ldJT5BjigpQM0wm43PZdxe5rcKmvmpCMq2vdum5IleBcYYb5vyAuGVEKowzKLWhil1J0vlrF0Oi4rjCqfhWo_hSo9gpUGwVy6fluxrBsnN0X7k6e8xe7vE75cj7q1oS0x1gpBCeU_gBmX4zn</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>PRAZUCK, T</creator><creator>TALL, F</creator><creator>LAFAIX, C</creator><creator>NACRO, B</creator><creator>ROCHEREAU, A</creator><creator>TRAORE, A</creator><creator>SANOU, T</creator><creator>MALKIN, J.-E</creator><creator>APAIRE-MARCHAIS, V</creator><creator>MASSON, D</creator><creator>DUBLANCHET, A</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>HIV infection and severe malnutrition : a clinical and epidemiological study in Burkina Faso</title><author>PRAZUCK, T ; TALL, F ; LAFAIX, C ; NACRO, B ; ROCHEREAU, A ; TRAORE, A ; SANOU, T ; MALKIN, J.-E ; APAIRE-MARCHAIS, V ; MASSON, D ; DUBLANCHET, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c230t-c0258445fc1f343a340f94df1bdbbae1bd6827244ddd2f8a5388f30e405726413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Burkina Faso - epidemiology</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - transmission</topic><topic>HIV-1</topic><topic>human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Kwashiorkor - complications</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Nutrition Disorders - complications</topic><topic>Population</topic><topic>Prognosis</topic><topic>Protein-Energy Malnutrition - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PRAZUCK, T</creatorcontrib><creatorcontrib>TALL, F</creatorcontrib><creatorcontrib>LAFAIX, C</creatorcontrib><creatorcontrib>NACRO, B</creatorcontrib><creatorcontrib>ROCHEREAU, A</creatorcontrib><creatorcontrib>TRAORE, A</creatorcontrib><creatorcontrib>SANOU, T</creatorcontrib><creatorcontrib>MALKIN, J.-E</creatorcontrib><creatorcontrib>APAIRE-MARCHAIS, V</creatorcontrib><creatorcontrib>MASSON, D</creatorcontrib><creatorcontrib>DUBLANCHET, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PRAZUCK, T</au><au>TALL, F</au><au>LAFAIX, C</au><au>NACRO, B</au><au>ROCHEREAU, A</au><au>TRAORE, A</au><au>SANOU, T</au><au>MALKIN, J.-E</au><au>APAIRE-MARCHAIS, V</au><au>MASSON, D</au><au>DUBLANCHET, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV infection and severe malnutrition : a clinical and epidemiological study in Burkina Faso</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>1993</date><risdate>1993</risdate><volume>7</volume><issue>1</issue><spage>103</spage><epage>108</epage><pages>103-108</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>To define a clinical profile indicative of HIV infection in a population of severely malnourished children in Burkina Faso. A total of 433 children (average age, 19 months) were recruited at the Sanou Souro National Hospital, Bobo Dioulasso, Burkina Faso.
Sixty-three per cent presented with marasmus, 13% with kwashiorkor and 24% with both forms of malnutrition. The prevalence of HIV infection in children aged over 12 months was 13.8%, with a marked predominance of HIV-1 (95.8%). Mother-to-child transmission was proven in 77% of the cases; in 10% of the observed paediatric AIDS cases, transmission may have occurred through multi-injections with contaminated equipment. Marasmus was the form of malnutrition most frequently associated with HIV (P < 0.001); its severity was exacerbated by HIV infection. Adenopathy (P < 0.0001), oral candidiasis (P < 0.0006), skin disorders (P < 0.01) and hepatomegaly (P = 0.01) appeared to be significantly related to HIV infection. Discriminant analysis revealed that the presence of adenopathies was the strongest indicator symptom of HIV infection. Multivariate analysis revealed that a clinical profile of marasmus, adenopathies and oral candidiasis (specificity, 82%) was indicative of HIV infection in this population. The short-term clinical prognosis was poor and usually led to the death of the child when seropositive (P < 0.001).
Among children exhibiting severe malnutrition, HIV-positive children are distinguished by a high horizontal transmission rate, a high specific clinical profile and a very poor prognosis.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>8442899</pmid><doi>10.1097/00002030-199301000-00016</doi><tpages>6</tpages></addata></record> |
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| ispartof | AIDS (London), 1993, Vol.7 (1), p.103-108 |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | AIDS/HIV Biological and medical sciences Burkina Faso - epidemiology Child, Preschool Female HIV Infections - complications HIV Infections - epidemiology HIV Infections - transmission HIV-1 human immunodeficiency virus Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infant Kwashiorkor - complications Male Medical sciences Multivariate Analysis Nutrition Disorders - complications Population Prognosis Protein-Energy Malnutrition - complications |
| title | HIV infection and severe malnutrition : a clinical and epidemiological study in Burkina Faso |
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