Carboxyl Methylation of Ras-Related Proteins During Signal Transduction in Neutrophils

In human neutrophils, as in other cell types, Ras-related guanosine triphosphate-binding proteins are directed toward their regulatory targets in membranes by a series of posttrans-lational modifications that include methyl esterification of a carboxyl-terminal prenylcysteine residue. In intact cell...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1993-02, Vol.259 (5097), p.977-980
Hauptverfasser:	Philips, Mark R., Pillinger, Michael H., Staud, Roland, Volker, Craig, Rosenfeld, Melvin G., Weissmann, Gerald, Stock, Jeffry B.
Format:	Artikel
Sprache:	eng
Schlagworte:	activation Automatic frequency control Average fixed cost Biological and medical sciences Cell Membrane - metabolism Cell membranes Cell physiology Cellular signal transduction chemoattractants Cytosol Cytosol - metabolism Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - metabolism Guanine Nucleotide Dissociation Inhibitors Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Guanosine Triphosphate - pharmacology Humans leukocytes (neutrophilic) man Methionine - analogs & derivatives Methionine - metabolism Methylation Molecular and cellular biology N-formyl-methionyl-leucyl-phenylalanine N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils Neutrophils - physiology P branes Plasma membranes Protein Methyltransferases - metabolism Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins p21(ras) - metabolism rap GTP-Binding Proteins ras-related protein rho-Specific Guanine Nucleotide Dissociation Inhibitors S-Adenosylmethionine - metabolism Signal transduction Signal Transduction - physiology String theory Tritium
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