Expression cloning of an epithelial amiloride-sensitive Na + channel : A new channel type with homologies to Caenorhabditis elegans degenerins
A complementary DNA encoding an amiloride-sensitive Na + channel has been cloned and characterized from rat colon. The protein encoded by the cDNA has a sequence of 699 amino acids (79 kDa) containing several putative membrane spanning domains and potential phosphorylation sites. It forms a channel...
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| Veröffentlicht in: | FEBS letters 1993-02, Vol.318 (1), p.95-99 |
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| creator | Lingueglia, Eric Voilley, Nicolas Waldmann, Rainer Lazdunski, Michel Barbry, Pascal |
| description | A complementary DNA encoding an amiloride-sensitive Na
+ channel has been cloned and characterized from rat colon. The protein encoded by the cDNA has a sequence of 699 amino acids (79 kDa) containing several putative membrane spanning domains and potential phosphorylation sites. It forms a channel that has the electrophysiological and pharmacological properties characteristic of the epithelial Na
+ channel. Homologies (including in transmembrane domains) have been found between a part of the channel sequence and the Mec4 gene product of
Caenorhabditis elegans, a protein associated with mutation-induced neuronal degeneration. |
| doi_str_mv | 10.1016/0014-5793(93)81336-X |
| format | Article |
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+ channel has been cloned and characterized from rat colon. The protein encoded by the cDNA has a sequence of 699 amino acids (79 kDa) containing several putative membrane spanning domains and potential phosphorylation sites. It forms a channel that has the electrophysiological and pharmacological properties characteristic of the epithelial Na
+ channel. Homologies (including in transmembrane domains) have been found between a part of the channel sequence and the Mec4 gene product of
Caenorhabditis elegans, a protein associated with mutation-induced neuronal degeneration.</description><subject>Amiloride</subject><subject>Amiloride - pharmacology</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - chemistry</subject><subject>Caenorhabditis elegans - genetics</subject><subject>Caenorhabditis elegans Proteins</subject><subject>Cloning, Molecular</subject><subject>Colon</subject><subject>Colon - chemistry</subject><subject>Colon - drug effects</subject><subject>DNA</subject><subject>Epithelia</subject><subject>Epithelial Sodium Channels</subject><subject>Epithelium - chemistry</subject><subject>Epithelium - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Helminth Proteins - chemistry</subject><subject>Helminth Proteins - genetics</subject><subject>Membrane Proteins - chemistry</subject><subject>Membrane Proteins - genetics</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Neuronal degeneration</subject><subject>Phosphorylation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sequence Homology, Amino Acid</subject><subject>Sodium channel</subject><subject>Sodium Channels - chemistry</subject><subject>Sodium Channels - drug effects</subject><subject>Sodium Channels - genetics</subject><subject>Xenopus</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVFrFDEQx4NY6ln9Bgp5EFHK6uayu8n6IJSjtkLRF4W-hdlk9i6STbaZvdZ-CT-ze95xj0IgDPP7_2f4D2OvRPlBlKL5WJaiKmrVynetfK-FlE1x-4QthFaykFWjn7LFEXnGnhP9Kudai_aUnWqpl0ItF-zP5e8xI5FPkduQoo9rnnoOkePopw0GD4HD4EPK3mFBGMlP_h75N-Dn3G4gRgz8E7_gER-O9fQ4In-Y9XyThhTS2iPxKfEVYEx5A52bTYhjwDVE4g7XGDH7SC_YSQ-B8OXhP2M_v1z-WF0XN9-vvq4ubgorZT0VqhUKu1ZLaARUvbLWuQ4bXQmllRUgpcUOml64Woi26XUJlWjbulLaaZSlPGNv975jTndbpMkMniyGABHTloyqa13PQ2aw2oM2J6KMvRmzHyA_GlGa3RnMLmOzy9jM798ZzO0se33w33YDuqPokPvcf3PoA1kIfYZoPR2xqlaiWu7W_LzHcM7i3mM2ZD1Gi85ntJNxyf9_j7_FAaW-</recordid><startdate>19930222</startdate><enddate>19930222</enddate><creator>Lingueglia, Eric</creator><creator>Voilley, Nicolas</creator><creator>Waldmann, Rainer</creator><creator>Lazdunski, Michel</creator><creator>Barbry, Pascal</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930222</creationdate><title>Expression cloning of an epithelial amiloride-sensitive Na + channel : A new channel type with homologies to Caenorhabditis elegans degenerins</title><author>Lingueglia, Eric ; Voilley, Nicolas ; Waldmann, Rainer ; Lazdunski, Michel ; Barbry, Pascal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-7917eb983a61a4f7ccddbe6841787c1a33ceba6f1d51196f80a41995478d8e303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Amiloride</topic><topic>Amiloride - pharmacology</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans - chemistry</topic><topic>Caenorhabditis elegans - genetics</topic><topic>Caenorhabditis elegans Proteins</topic><topic>Cloning, Molecular</topic><topic>Colon</topic><topic>Colon - chemistry</topic><topic>Colon - drug effects</topic><topic>DNA</topic><topic>Epithelia</topic><topic>Epithelial Sodium Channels</topic><topic>Epithelium - chemistry</topic><topic>Epithelium - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Helminth Proteins - chemistry</topic><topic>Helminth Proteins - genetics</topic><topic>Membrane Proteins - chemistry</topic><topic>Membrane Proteins - genetics</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Neuronal degeneration</topic><topic>Phosphorylation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sequence Homology, Amino Acid</topic><topic>Sodium channel</topic><topic>Sodium Channels - chemistry</topic><topic>Sodium Channels - drug effects</topic><topic>Sodium Channels - genetics</topic><topic>Xenopus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lingueglia, Eric</creatorcontrib><creatorcontrib>Voilley, Nicolas</creatorcontrib><creatorcontrib>Waldmann, Rainer</creatorcontrib><creatorcontrib>Lazdunski, Michel</creatorcontrib><creatorcontrib>Barbry, Pascal</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lingueglia, Eric</au><au>Voilley, Nicolas</au><au>Waldmann, Rainer</au><au>Lazdunski, Michel</au><au>Barbry, Pascal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression cloning of an epithelial amiloride-sensitive Na + channel : A new channel type with homologies to Caenorhabditis elegans degenerins</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1993-02-22</date><risdate>1993</risdate><volume>318</volume><issue>1</issue><spage>95</spage><epage>99</epage><pages>95-99</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>A complementary DNA encoding an amiloride-sensitive Na
+ channel has been cloned and characterized from rat colon. The protein encoded by the cDNA has a sequence of 699 amino acids (79 kDa) containing several putative membrane spanning domains and potential phosphorylation sites. It forms a channel that has the electrophysiological and pharmacological properties characteristic of the epithelial Na
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Caenorhabditis elegans, a protein associated with mutation-induced neuronal degeneration.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8382172</pmid><doi>10.1016/0014-5793(93)81336-X</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier); Alma/SFX Local Collection |
| subjects | Amiloride Amiloride - pharmacology Amino Acid Sequence Animals Base Sequence Biological and medical sciences Caenorhabditis elegans Caenorhabditis elegans - chemistry Caenorhabditis elegans - genetics Caenorhabditis elegans Proteins Cloning, Molecular Colon Colon - chemistry Colon - drug effects DNA Epithelia Epithelial Sodium Channels Epithelium - chemistry Epithelium - drug effects Fundamental and applied biological sciences. Psychology Gene expression Helminth Proteins - chemistry Helminth Proteins - genetics Membrane Proteins - chemistry Membrane Proteins - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Neuronal degeneration Phosphorylation Rats Rats, Wistar Sequence Homology, Amino Acid Sodium channel Sodium Channels - chemistry Sodium Channels - drug effects Sodium Channels - genetics Xenopus |
| title | Expression cloning of an epithelial amiloride-sensitive Na + channel : A new channel type with homologies to Caenorhabditis elegans degenerins |
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