Carrageenan stimulates populations of mouse “B” cells mostly nonoverlapping with those stimulated with LPS or dextran sulfate
Mouse spleen cells have been stimulated in vitro with three different mitogens: lipopolysaccharide, dextran sulfate, and ι-carrageenan. After removal of the blast cells by either filtration through Sephadex G-10, uv illumination following the incorporation of bromodeoxyuridine, or separation by dens...
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| Veröffentlicht in: | Cellular immunology 1981-01, Vol.57 (2), p.348-360 |
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| container_title | Cellular immunology |
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| creator | Kolb, Jean-Pierre B. Quan, Phuc Canh Poupon, Marie-France Desaymard, Catherine |
| description | Mouse spleen cells have been stimulated
in vitro with three different mitogens: lipopolysaccharide, dextran sulfate, and ι-carrageenan. After removal of the blast cells by either filtration through Sephadex G-10, uv illumination following the incorporation of bromodeoxyuridine, or separation by density gradient centrifugation, the remaining cells are only poorly restimulated with the mitogen used in the first culture, yet they are significantly restimulated with the other two mitogens. Furthermore, in irradiated, bone-marrow-reconstituted mice, the kinetics of reappearance of a mitogenic reactivity are different for the three mitogens tested. Thus, LPS, dextran sulfate, and carrageenan seem to act on subpopulations of “B” cells which are mostly nonoverlapping. |
| doi_str_mv | 10.1016/0008-8749(81)90093-9 |
| format | Article |
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in vitro with three different mitogens: lipopolysaccharide, dextran sulfate, and ι-carrageenan. After removal of the blast cells by either filtration through Sephadex G-10, uv illumination following the incorporation of bromodeoxyuridine, or separation by density gradient centrifugation, the remaining cells are only poorly restimulated with the mitogen used in the first culture, yet they are significantly restimulated with the other two mitogens. Furthermore, in irradiated, bone-marrow-reconstituted mice, the kinetics of reappearance of a mitogenic reactivity are different for the three mitogens tested. Thus, LPS, dextran sulfate, and carrageenan seem to act on subpopulations of “B” cells which are mostly nonoverlapping.</description><subject>Animals</subject><subject>B-Lymphocytes - immunology</subject><subject>Carrageenan - pharmacology</subject><subject>Cell Separation</subject><subject>Dextran Sulfate</subject><subject>Dextrans - pharmacology</subject><subject>Female</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred DBA</subject><subject>Mice, Nude</subject><subject>Mitogens</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAUhS0EKkPhDUDyCtFF4Dq2k3iDVEYFKo0EErC2PM5Na5TEwXb6s2vfA16uT4LDjGbJytY9556r8xHyksFbBqx6BwBN0dRCvWnYiQJQvFCPyIqBgqJkFX9MVgfLU_Isxp8AjAkFR-SoyrqU5Yrcr00I5gJxNCONyQ1zbxJGOvlp-Tk_Ruo7Ovg5In24-_3h4e4Ptdj3Mc9i6m_p6Ed_haE30-TGC3rt0iVNlz7bD3Htbrr5-o36QFu8SWG5NvddFp-TJ53pI77Yv8fkx8ez7-vPxebLp_P16aawXNap2HKBNTSCt1spO6hMx5VgppOykSVH1RlRCtsqrhRnxnJlUZUg2sYYlKWq-DF5vcudgv81Y0x6cHFpYkbM7XSdkxhUdTaKndEGH2PATk_BDSbcagZ6Ia8XrHrBqhum_5HXKq-92ufP2wHbw9Ieddbf73TMJa8cBh2tw9Fi6wLapFvv_n_gL3culug</recordid><startdate>19810115</startdate><enddate>19810115</enddate><creator>Kolb, Jean-Pierre B.</creator><creator>Quan, Phuc Canh</creator><creator>Poupon, Marie-France</creator><creator>Desaymard, Catherine</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19810115</creationdate><title>Carrageenan stimulates populations of mouse “B” cells mostly nonoverlapping with those stimulated with LPS or dextran sulfate</title><author>Kolb, Jean-Pierre B. ; Quan, Phuc Canh ; Poupon, Marie-France ; Desaymard, Catherine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-b34e70843db55f06af3941af558523e9fa424cd939931ac39ce9204d8aae52963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>B-Lymphocytes - immunology</topic><topic>Carrageenan - pharmacology</topic><topic>Cell Separation</topic><topic>Dextran Sulfate</topic><topic>Dextrans - pharmacology</topic><topic>Female</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred DBA</topic><topic>Mice, Nude</topic><topic>Mitogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kolb, Jean-Pierre B.</creatorcontrib><creatorcontrib>Quan, Phuc Canh</creatorcontrib><creatorcontrib>Poupon, Marie-France</creatorcontrib><creatorcontrib>Desaymard, Catherine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kolb, Jean-Pierre B.</au><au>Quan, Phuc Canh</au><au>Poupon, Marie-France</au><au>Desaymard, Catherine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carrageenan stimulates populations of mouse “B” cells mostly nonoverlapping with those stimulated with LPS or dextran sulfate</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>1981-01-15</date><risdate>1981</risdate><volume>57</volume><issue>2</issue><spage>348</spage><epage>360</epage><pages>348-360</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><abstract>Mouse spleen cells have been stimulated
in vitro with three different mitogens: lipopolysaccharide, dextran sulfate, and ι-carrageenan. After removal of the blast cells by either filtration through Sephadex G-10, uv illumination following the incorporation of bromodeoxyuridine, or separation by density gradient centrifugation, the remaining cells are only poorly restimulated with the mitogen used in the first culture, yet they are significantly restimulated with the other two mitogens. Furthermore, in irradiated, bone-marrow-reconstituted mice, the kinetics of reappearance of a mitogenic reactivity are different for the three mitogens tested. Thus, LPS, dextran sulfate, and carrageenan seem to act on subpopulations of “B” cells which are mostly nonoverlapping.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>6163552</pmid><doi>10.1016/0008-8749(81)90093-9</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Cellular immunology, 1981-01, Vol.57 (2), p.348-360 |
| issn | 0008-8749 1090-2163 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals B-Lymphocytes - immunology Carrageenan - pharmacology Cell Separation Dextran Sulfate Dextrans - pharmacology Female Lipopolysaccharides - pharmacology Lymphocyte Activation Male Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Nude Mitogens |
| title | Carrageenan stimulates populations of mouse “B” cells mostly nonoverlapping with those stimulated with LPS or dextran sulfate |
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