Regulation of Serine Protease Activity by Aluminum: Implications for Alzheimer Disease

The brain of Alzheimer disease patients contains plaques that are diagnostic for the disease. The plaques also contain β-amyloid peptide, α1-antichymotrypsin, and the element aluminum. We present indirect evidence that can relate all three components of plaques to each other in such a way as to sugg...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-02, Vol.90 (3), p.1009-1012
Hauptverfasser:	CLAUBERG, M, JOSHI, J. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum Aluminum - pharmacology Alzheimer Disease - enzymology Alzheimer Disease - etiology Alzheimer's disease Alzheimers disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Aprotinin - metabolism Biological and medical sciences Brain Brain - enzymology Brain - metabolism Chymotrypsin - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Enzyme Activation Enzymes Ferritins Humans Hydrogen-Ion Concentration Medical research Medical sciences Neurology Physiological regulation Protease inhibitors Protein precursors Serine Endopeptidases - drug effects Transferrin - metabolism Transferrins Ungulates
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