Characterisation of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus

The transient activation of the N- methyl- D- aspartate (NMDA) receptor system by high frequency (tetanic) stimulation results in a rapidly developing and long-lasting potentiation of synaptic transmission in the CA1 region of the hippocampus. This potentiation can be divided into an early decrement...

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Veröffentlicht in:	Neuropharmacology 1993, Vol.32 (1), p.1-9
Hauptverfasser:	Bortolotto, Zuner A., Collingridge, Graham L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Animals Biological and medical sciences Ca 2+ stores Calcium-Transporting ATPases - antagonists & inhibitors Central nervous system Cycloleucine - analogs & derivatives Cycloleucine - pharmacology Electric Stimulation Electrophysiology Fundamental and applied biological sciences. Psychology glutamate metabotropic receptor hippocampus Hippocampus - drug effects Hippocampus - metabolism In Vitro Techniques long-term potentiation Neuronal Plasticity - drug effects NMDA receptor Phosphatidylinositols - physiology protein kinase C Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Rats Receptors, Glutamate - drug effects Receptors, N-Methyl-D-Aspartate - physiology Signal Transduction - physiology Staurosporine Stereoisomerism Synapses - drug effects Synapses - metabolism Terpenes - pharmacology Thapsigargin Vertebrates: nervous system and sense organs
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