Diversity of immunoglobulin expression in leukaemic cells resembling B-lymphocyte precursors
Approximately 20% of patients with acute lymphocytic leukaemia (ALL) have leukaemic blasts with features of pre-B cells 1 which are the recently characterized precursors of B lymphocytes in normal development (for a review, see ref. 2). Pre-B cells isolated from normal bone marrow or fetal liver, an...
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| Veröffentlicht in: | Nature (London) 1981-03, Vol.290 (5804), p.339-341 |
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| creator | Vogler, L. B Preud'homme, J. L Seligmann, M Gathings, W. E Crist, W. M Cooper, M. D Bollum, F. J |
| description | Approximately 20% of patients with acute lymphocytic leukaemia (ALL) have leukaemic blasts with features of pre-B cells
1
which are the recently characterized precursors of B lymphocytes in normal development (for a review, see ref. 2). Pre-B cells isolated from normal bone marrow or fetal liver, and malignant cells from patients with pre-B cell leukaemia, are rapidly dividing lymphoid cells that contain cytoplasmic immunoglobulin
μ
heavy chains, but have no detectable surface immunoglobulin. The resemblance of immunoglobulin-containing ALL cells to normal precursors of B lymphocytes and their availability in relatively pure preparations allowed us to explore them as models of early stages in the differentiation of the B-lymphocyte line. We report here observations on the occurrence of intermediate pre-B/B-cell phenotypes, immunoglobulin isotype switching and the asynchrony of immunoglobulin heavy and light chain expression in 30 cases of ALL and 3 cases of chronic myelogenous leukaemia in lymphoblastic crisis (CML-BC). |
| doi_str_mv | 10.1038/290339a0 |
| format | Article |
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1
which are the recently characterized precursors of B lymphocytes in normal development (for a review, see ref. 2). Pre-B cells isolated from normal bone marrow or fetal liver, and malignant cells from patients with pre-B cell leukaemia, are rapidly dividing lymphoid cells that contain cytoplasmic immunoglobulin
μ
heavy chains, but have no detectable surface immunoglobulin. The resemblance of immunoglobulin-containing ALL cells to normal precursors of B lymphocytes and their availability in relatively pure preparations allowed us to explore them as models of early stages in the differentiation of the B-lymphocyte line. We report here observations on the occurrence of intermediate pre-B/B-cell phenotypes, immunoglobulin isotype switching and the asynchrony of immunoglobulin heavy and light chain expression in 30 cases of ALL and 3 cases of chronic myelogenous leukaemia in lymphoblastic crisis (CML-BC).</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/290339a0</identifier><identifier>PMID: 6782491</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>B-Lymphocytes - cytology ; B-Lymphocytes - immunology ; Cell Differentiation ; Gene Expression Regulation ; Humanities and Social Sciences ; Humans ; Immunoglobulin alpha-Chains - genetics ; Immunoglobulin gamma-Chains - genetics ; Immunoglobulin Light Chains - genetics ; Immunoglobulin mu-Chains - genetics ; letter ; Leukemia, Myeloid - immunology ; Leukemia, Myeloid, Acute - immunology ; multidisciplinary ; Receptors, Antigen, B-Cell - genetics ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1981-03, Vol.290 (5804), p.339-341</ispartof><rights>Springer Nature Limited 1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2500-ec3a1b2c6ba0a9f8c10aa8d44030325de03f0a80892eb141295f4cec39a6c2733</citedby><cites>FETCH-LOGICAL-c2500-ec3a1b2c6ba0a9f8c10aa8d44030325de03f0a80892eb141295f4cec39a6c2733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/290339a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/290339a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6782491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vogler, L. B</creatorcontrib><creatorcontrib>Preud'homme, J. L</creatorcontrib><creatorcontrib>Seligmann, M</creatorcontrib><creatorcontrib>Gathings, W. E</creatorcontrib><creatorcontrib>Crist, W. M</creatorcontrib><creatorcontrib>Cooper, M. D</creatorcontrib><creatorcontrib>Bollum, F. J</creatorcontrib><title>Diversity of immunoglobulin expression in leukaemic cells resembling B-lymphocyte precursors</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Approximately 20% of patients with acute lymphocytic leukaemia (ALL) have leukaemic blasts with features of pre-B cells
1
which are the recently characterized precursors of B lymphocytes in normal development (for a review, see ref. 2). Pre-B cells isolated from normal bone marrow or fetal liver, and malignant cells from patients with pre-B cell leukaemia, are rapidly dividing lymphoid cells that contain cytoplasmic immunoglobulin
μ
heavy chains, but have no detectable surface immunoglobulin. The resemblance of immunoglobulin-containing ALL cells to normal precursors of B lymphocytes and their availability in relatively pure preparations allowed us to explore them as models of early stages in the differentiation of the B-lymphocyte line. We report here observations on the occurrence of intermediate pre-B/B-cell phenotypes, immunoglobulin isotype switching and the asynchrony of immunoglobulin heavy and light chain expression in 30 cases of ALL and 3 cases of chronic myelogenous leukaemia in lymphoblastic crisis (CML-BC).</description><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - immunology</subject><subject>Cell Differentiation</subject><subject>Gene Expression Regulation</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immunoglobulin alpha-Chains - genetics</subject><subject>Immunoglobulin gamma-Chains - genetics</subject><subject>Immunoglobulin Light Chains - genetics</subject><subject>Immunoglobulin mu-Chains - genetics</subject><subject>letter</subject><subject>Leukemia, Myeloid - immunology</subject><subject>Leukemia, Myeloid, Acute - immunology</subject><subject>multidisciplinary</subject><subject>Receptors, Antigen, B-Cell - genetics</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtPwzAQhC0EKqUg8QdAOSE4BNaPJM4RylOqxAVuSJHjbkogiYNdI_rvcZXSE6fVar4Z7Q4hxxQuKXB5xXLgPFewQ8ZUZGksUpntkjEAkzFInu6TA-c-ACChmRiRUZpJJnI6Jm-39TdaVy9Xkamium19ZxaNKX1TdxH-9Badq00Xha1B_6mwrXWksWlcFCRsy8Atopu4WbX9u9GrJUbBo711xrpDslepxuHRZk7I6_3dy_Qxnj0_PE2vZ7FmCUCMmitaMp2WClReSU1BKTkXAjhwlswReAVKgswZllRQlieV0MGVq1SzjPMJORtye2u-PLpl0dZufaTq0HhXZEmSJcBFAM8HUFvjnMWq6G3dKrsqKBTrIou_IgN6ssn0ZYvzLbhpLugXg-6C0i3QFh_G2y68-V_W6cB2auktbrO2wC93MoY4</recordid><startdate>19810326</startdate><enddate>19810326</enddate><creator>Vogler, L. 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B</creatorcontrib><creatorcontrib>Preud'homme, J. L</creatorcontrib><creatorcontrib>Seligmann, M</creatorcontrib><creatorcontrib>Gathings, W. E</creatorcontrib><creatorcontrib>Crist, W. M</creatorcontrib><creatorcontrib>Cooper, M. D</creatorcontrib><creatorcontrib>Bollum, F. J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vogler, L. B</au><au>Preud'homme, J. L</au><au>Seligmann, M</au><au>Gathings, W. E</au><au>Crist, W. M</au><au>Cooper, M. D</au><au>Bollum, F. 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1
which are the recently characterized precursors of B lymphocytes in normal development (for a review, see ref. 2). Pre-B cells isolated from normal bone marrow or fetal liver, and malignant cells from patients with pre-B cell leukaemia, are rapidly dividing lymphoid cells that contain cytoplasmic immunoglobulin
μ
heavy chains, but have no detectable surface immunoglobulin. The resemblance of immunoglobulin-containing ALL cells to normal precursors of B lymphocytes and their availability in relatively pure preparations allowed us to explore them as models of early stages in the differentiation of the B-lymphocyte line. We report here observations on the occurrence of intermediate pre-B/B-cell phenotypes, immunoglobulin isotype switching and the asynchrony of immunoglobulin heavy and light chain expression in 30 cases of ALL and 3 cases of chronic myelogenous leukaemia in lymphoblastic crisis (CML-BC).</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>6782491</pmid><doi>10.1038/290339a0</doi><tpages>3</tpages></addata></record> |
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| ispartof | Nature (London), 1981-03, Vol.290 (5804), p.339-341 |
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| language | eng |
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| subjects | B-Lymphocytes - cytology B-Lymphocytes - immunology Cell Differentiation Gene Expression Regulation Humanities and Social Sciences Humans Immunoglobulin alpha-Chains - genetics Immunoglobulin gamma-Chains - genetics Immunoglobulin Light Chains - genetics Immunoglobulin mu-Chains - genetics letter Leukemia, Myeloid - immunology Leukemia, Myeloid, Acute - immunology multidisciplinary Receptors, Antigen, B-Cell - genetics Science Science (multidisciplinary) |
| title | Diversity of immunoglobulin expression in leukaemic cells resembling B-lymphocyte precursors |
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