Aldose Reductase Inhibition Restores Endothelial Cell Function in Diabetic Rabbit Aorta

A possible relationship between increased aldose reductase activity and abnormal endothelium-dependent relaxation was examined in aorta from al-loxan-induced diabetic rabbits. Isolated aorta of diabetic rabbits, contracted submaximally with phenylephrine, showed significantly decreased endothelium-d...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1993-02, Vol.21 (2), p.205-205
Hauptverfasser:	Tesfamariam, Belay, Palacino, James J, Weisbrod, Robert M, Cohen, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Adenosine Diphosphate - pharmacology Aldehyde Reductase - antagonists & inhibitors Animals Aorta - physiopathology Biological and medical sciences Blood Glucose - metabolism Body Weight - drug effects Cardiovascular system Cyclic GMP - metabolism Diabetes Mellitus, Experimental - physiopathology Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Imidazoles - pharmacology Imidazolidines In Vitro Techniques Male Medical sciences Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects Pharmacology. Drug treatments Phenylephrine - pharmacology Prostaglandins - metabolism Rabbits Sorbitol - blood Vascular wall
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