ATP-Modulated K+Channels Sensitive to Antidiabetic Sulfonylureas are Present in Adenohypophysis and are Involved in Growth Hormone Release

The adenohypophysis contains high-affinity binding sites for antidiabetic sulfonylureas that are specific blockers of ATP-sensitive K+channels. The binding protein has a Mrof 145,000 ± 5000. The presence of ATP-sensitive K+channels (26 pS) has been demonstrated by electrophysiological techniques. In...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-02, Vol.90 (4), p.1340-1344
Hauptverfasser:	Bernardi, Henri, De Weille, Jan R., Epelbaum, Jacques, Mourre, Christiane, Amoroso, Salvatore, Slama, Annie, Fosset, Michel, Lazdunski, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Adenosine Triphosphate - pharmacology Affinity Labels - metabolism Animals Anterior pituitary B lymphocytes Binding sites Biological and medical sciences Calcium - metabolism Cells, Cultured Computer Science Diazoxide - pharmacology Electrophysiology Female Fundamental and applied biological sciences. Psychology Glipizide - pharmacology Glyburide - metabolism Growth Hormone - metabolism Growth hormones Hypoglycemic agents Hypoglycemic Agents - pharmacology Hypothalamus. Hypophysis. Epiphysis. Urophysis Kinetics Life Sciences Membrane Potentials - drug effects Microsomes Morphology. Functional localizations Oligomycins - pharmacology Pancreatic cells Pituitary gland Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Pituitary Gland, Anterior - physiology Potassium Channels - drug effects Potassium Channels - physiology Rats Receptors, Drug - metabolism Secretion Sulfonylurea Compounds - pharmacology Vertebrates: endocrinology
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