Effects of nutrition on brain development in humans
Brain development in humans is remarkably resistant to permanent damage from protein-energy malnutrition. However, specific nutrients have crucial roles. Iodine deficiency is the most important and widespread nutrient deficiency; it causes endemic cretinism, associated with deaf-mutism and cerebral...
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| Veröffentlicht in: | The American journal of clinical nutrition 1993-02, Vol.57 (2), p.286S-290S |
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| description | Brain development in humans is remarkably resistant to permanent damage from protein-energy malnutrition. However, specific nutrients have crucial roles. Iodine deficiency is the most important and widespread nutrient deficiency; it causes endemic cretinism, associated with deaf-mutism and cerebral palsy. Iodine deficiency during pregnancy causes both maternal and fetal hypothyroxinemia, resulting in irreversible impairment of brain development at a critical stage. Neuropathological data place this after 14 wk, perhaps continuing through the third trimester. Gross brain structure, including the gyral pattern of the cerebral cortex, develops normally; the insult affects neuron and dendrite growth. Recent magnetic-resonance-imaging (MRI) images of neurological cretin brains show remarkably normal appearance except for gliotic lesions of the globus pallidus, correlating with the proximal motor rigidity seen clinically. Myxedematous cretinism is paradoxical in showing more severe hypothyroidism and growth failure, yet better intellectual, motor, and hearing function; these observations implicate a second independent factor in its pathogenesis. |
| doi_str_mv | 10.1093/ajcn/57.2.286S |
| format | Article |
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However, specific nutrients have crucial roles. Iodine deficiency is the most important and widespread nutrient deficiency; it causes endemic cretinism, associated with deaf-mutism and cerebral palsy. Iodine deficiency during pregnancy causes both maternal and fetal hypothyroxinemia, resulting in irreversible impairment of brain development at a critical stage. Neuropathological data place this after 14 wk, perhaps continuing through the third trimester. Gross brain structure, including the gyral pattern of the cerebral cortex, develops normally; the insult affects neuron and dendrite growth. Recent magnetic-resonance-imaging (MRI) images of neurological cretin brains show remarkably normal appearance except for gliotic lesions of the globus pallidus, correlating with the proximal motor rigidity seen clinically. Myxedematous cretinism is paradoxical in showing more severe hypothyroidism and growth failure, yet better intellectual, motor, and hearing function; these observations implicate a second independent factor in its pathogenesis.</description><subject>Avitaminosis - complications</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - embryology</subject><subject>CARENCE EN OLIGOELEMENT</subject><subject>CARENCE EN VITAMINE</subject><subject>CARENCE MINERALE</subject><subject>CARENCE PROTEIQUE</subject><subject>CEREBRO</subject><subject>Congenital Hypothyroidism - etiology</subject><subject>cretinism</subject><subject>DEFICIENCIA DE MINERALES</subject><subject>DEFICIENCIA DE OLIGOELEMENTOS</subject><subject>DEFICIENCIA DE PROTEINAS</subject><subject>DEFICIENCIA DE VITAMINAS</subject><subject>DESARROLLO EMBRIONARIO</subject><subject>DEVELOPPEMENT EMBRYONNAIRE</subject><subject>ENCEPHALE</subject><subject>ENFERMEDADES GLANDULAS ENDOCRINAS</subject><subject>Female</subject><subject>fetal brain</subject><subject>Fetuses</subject><subject>GLANDULA TIROIDE</subject><subject>Humans</subject><subject>IODE</subject><subject>iodine</subject><subject>Iodine - deficiency</subject><subject>MALNUTRICION</subject><subject>MALNUTRITION</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>neuropathology</subject><subject>Nutrition</subject><subject>Nutritional Physiological Phenomena</subject><subject>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><subject>Pregnancy</subject><subject>THYROIDE</subject><subject>TROUBLE ENDOCRINIEN</subject><subject>YODO</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9rHCEUx6W0pNuk1x4KhaGU3mbz_DXqMYS0DQR6SHIWdbR1mdGtzgTy39dllxwKBUHl-_Hx3keEPmDYYlD00uxcuuRiS7ZEDvev0AYrKntKQLxGGwAgvcIDf4ve1boDwITJ4QydSUYEgWGD6E0I3i21y6FL61LiEnPq2rLFxNSN_slPeT_7tHTt-nudTaoX6E0wU_XvT_s5evx283D9o7_7-f32-uqud5zA0hMirLNWcaCWW6K4cd6DwwwDD4MEBcp5y1SwwpFgqDOGKRxsO4wjFZKeo6_HuvuS_6y-LnqO1flpMsnntWrBucCM0QZ-_gfc5bWk1psmFKs2q8QN2h4hV3KtxQe9L3E25Vlj0AeV-qBSc6GJPqhsDz6dqq529uMLfnLX8i-n3FRnplBMcrG-YIxLaDM27OMRCyZr86s05PFeUTIIwVooj6FvHp-iL7q66JPzYyztW_SY4__a-wuSIJcO</recordid><startdate>19930201</startdate><enddate>19930201</enddate><creator>DeLong, GR</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19930201</creationdate><title>Effects of nutrition on brain development in humans</title><author>DeLong, GR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-227bcbb9503b5b295acee0c14105f680909ceb49fb7c2fa3caa491fb3cadd3783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Avitaminosis - complications</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - embryology</topic><topic>CARENCE EN OLIGOELEMENT</topic><topic>CARENCE EN VITAMINE</topic><topic>CARENCE MINERALE</topic><topic>CARENCE PROTEIQUE</topic><topic>CEREBRO</topic><topic>Congenital Hypothyroidism - etiology</topic><topic>cretinism</topic><topic>DEFICIENCIA DE MINERALES</topic><topic>DEFICIENCIA DE OLIGOELEMENTOS</topic><topic>DEFICIENCIA DE PROTEINAS</topic><topic>DEFICIENCIA DE VITAMINAS</topic><topic>DESARROLLO EMBRIONARIO</topic><topic>DEVELOPPEMENT EMBRYONNAIRE</topic><topic>ENCEPHALE</topic><topic>ENFERMEDADES GLANDULAS ENDOCRINAS</topic><topic>Female</topic><topic>fetal brain</topic><topic>Fetuses</topic><topic>GLANDULA TIROIDE</topic><topic>Humans</topic><topic>IODE</topic><topic>iodine</topic><topic>Iodine - deficiency</topic><topic>MALNUTRICION</topic><topic>MALNUTRITION</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>neuropathology</topic><topic>Nutrition</topic><topic>Nutritional Physiological Phenomena</topic><topic>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</topic><topic>Pregnancy</topic><topic>THYROIDE</topic><topic>TROUBLE ENDOCRINIEN</topic><topic>YODO</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DeLong, GR</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DeLong, GR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of nutrition on brain development in humans</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1993-02-01</date><risdate>1993</risdate><volume>57</volume><issue>2</issue><spage>286S</spage><epage>290S</epage><pages>286S-290S</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Brain development in humans is remarkably resistant to permanent damage from protein-energy malnutrition. However, specific nutrients have crucial roles. Iodine deficiency is the most important and widespread nutrient deficiency; it causes endemic cretinism, associated with deaf-mutism and cerebral palsy. Iodine deficiency during pregnancy causes both maternal and fetal hypothyroxinemia, resulting in irreversible impairment of brain development at a critical stage. Neuropathological data place this after 14 wk, perhaps continuing through the third trimester. Gross brain structure, including the gyral pattern of the cerebral cortex, develops normally; the insult affects neuron and dendrite growth. Recent magnetic-resonance-imaging (MRI) images of neurological cretin brains show remarkably normal appearance except for gliotic lesions of the globus pallidus, correlating with the proximal motor rigidity seen clinically. 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| subjects | Avitaminosis - complications Biological and medical sciences Brain Brain - embryology CARENCE EN OLIGOELEMENT CARENCE EN VITAMINE CARENCE MINERALE CARENCE PROTEIQUE CEREBRO Congenital Hypothyroidism - etiology cretinism DEFICIENCIA DE MINERALES DEFICIENCIA DE OLIGOELEMENTOS DEFICIENCIA DE PROTEINAS DEFICIENCIA DE VITAMINAS DESARROLLO EMBRIONARIO DEVELOPPEMENT EMBRYONNAIRE ENCEPHALE ENFERMEDADES GLANDULAS ENDOCRINAS Female fetal brain Fetuses GLANDULA TIROIDE Humans IODE iodine Iodine - deficiency MALNUTRICION MALNUTRITION Medical research Medical sciences Metabolic diseases neuropathology Nutrition Nutritional Physiological Phenomena Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Pregnancy THYROIDE TROUBLE ENDOCRINIEN YODO |
| title | Effects of nutrition on brain development in humans |
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