Estradiol induction of rhodamine 123 efflux and the multidrug resistance pump in rat pituitary tumor cells

Rhodamine 123 is a fluorescent dye that localizes in mitochondria, is a substrate for the multidrug resistance pump, and is retained for long periods of time by carcinoma cells. 17 beta-Estradiol causes GH4C1 cells (rat pituitary tumor cells) to lose rhodamine 123 fluorescence faster than untreated...

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Veröffentlicht in:	Molecular pharmacology 1993-01, Vol.43 (1), p.51-56
Hauptverfasser:	JANCIS, E. M, CARBONE, R, LOECHNER, K. J, DANNIES, P. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cyclosporins - pharmacology Drug Resistance - genetics Estradiol - pharmacology General aspects Medical sciences Pharmacology. Drug treatments Pituitary Neoplasms - metabolism Rats Rhodamine 123 Rhodamines - pharmacokinetics RNA, Messenger - analysis Tumor Cells, Cultured Verapamil - pharmacology
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