Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Genomes Detected in Plasma Distinct from Viral Genomes in Peripheral Blood Mononuclear Cells

The emergence of zidovudine (3′-azido-2′,3′-deoxythymidine)-resistant strains of human immunodeficiency virus type 1 (HIV-1) from AIDS patients treated with zidovudine has been linked to six amino acid substitutions localized within the viral polymerase gene. Here, in 2 patients, three resistance mu...

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Veröffentlicht in:	The Journal of infectious diseases 1993-02, Vol.167 (2), p.445-448
Hauptverfasser:	Smith, Marilyn S., Koerber, Karen L., Pagano, Joseph S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - microbiology AIDS AIDS/HIV Biological and medical sciences Blood plasma Codons Concise Communications Cultured cells DNA, Viral - chemistry Dose-Response Relationship, Drug Drug Resistance, Microbial - genetics Fundamental and applied biological sciences. Psychology Genetic mutation Genetics Genotype Genotypes HIV 1 HIV Reverse Transcriptase HIV-1 - drug effects HIV-1 - genetics human immunodeficiency virus Humans Leukocytes, Mononuclear - microbiology Microbiology Mutation Plasma - microbiology Polymerase Chain Reaction RNA-Directed DNA Polymerase - genetics T lymphocytes Virology Viruses Zidovudine - pharmacology Zidovudine - therapeutic use
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