Enhanced c-erbB-2/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A

Amplification or overexpression of c-erbB-2/neu protooncogene, or both, occur frequently in many different types of human cancers and have been shown to correlate with decreased survival in ovarian cancer patients. We have previously found that the ovarian carcinoma cell line SK-OV-3 overexpresses c...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1993-02, Vol.53 (4), p.891-898
Hauptverfasser:	DIHUA YU, WOLF, J. K, SCANLON, M, PRICE, J. E, MIEN-CHIE HUNG
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus E1A Proteins - biosynthesis Adenovirus E1A Proteins - genetics Animals Biological and medical sciences Cell Division Cell Transformation, Neoplastic - genetics Female Female genital diseases Gene Amplification Gene Expression Regulation, Neoplastic - genetics Genes, Tumor Suppressor - genetics Genes, Viral Gynecology. Andrology. Obstetrics Humans Medical sciences Mice Mice, Nude Neoplasm Transplantation Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Receptor, ErbB-2 Transfection Tumor Cells, Cultured Tumor Stem Cell Assay Tumors
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