Occurrence of Clostridium difficile toxin during the course of inflammatory bowel disease
Clostridium difficile toxin, the presumed mechanism of antibiotic-associated pseudomembranous colitis, has been suggested as a contributory factor to mucosal injury in inflammatory bowel disease. We evaluated its incidence and apparent role in 65 consecutive patients with diarrheal and inflammatory...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1981-04, Vol.80 (4), p.697-700 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
| container_volume | 80 |
| creator | Meyers, S. Mayer, L. Bottone, E. Desmond, E. Janowitz, H.D. |
| description | Clostridium difficile toxin, the presumed mechanism of antibiotic-associated pseudomembranous colitis, has been suggested as a contributory factor to mucosal injury in inflammatory bowel disease. We evaluated its incidence and apparent role in 65 consecutive patients with diarrheal and inflammatory bowel diseases. Toxin was demonstrated in 3 of 18 patients with ulcerative colitis (17%), 1 of 26 with Crohn's colitis (4%), and 5 of 21 with a variety of diarrheal illnesses (24%). Toxin appeared only in those who had been exposed to antimicrobials within 2 mo. In inflammatory bowel disease, presence of toxin was not correlated with disease severity. We conclude that Clostridium difficile toxin appears only in patients exposed to antimicrobials and is unlikely to be a significant contributory factor in inflammatory bowel disease. |
| doi_str_mv | 10.1016/0016-5085(81)90128-1 |
| format | Article |
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We evaluated its incidence and apparent role in 65 consecutive patients with diarrheal and inflammatory bowel diseases. Toxin was demonstrated in 3 of 18 patients with ulcerative colitis (17%), 1 of 26 with Crohn's colitis (4%), and 5 of 21 with a variety of diarrheal illnesses (24%). Toxin appeared only in those who had been exposed to antimicrobials within 2 mo. In inflammatory bowel disease, presence of toxin was not correlated with disease severity. We conclude that Clostridium difficile toxin appears only in patients exposed to antimicrobials and is unlikely to be a significant contributory factor in inflammatory bowel disease.</description><identifier>ISSN: 0016-5085</identifier><identifier>ISSN: 1528-0012</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/0016-5085(81)90128-1</identifier><identifier>PMID: 7202942</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anti-Bacterial Agents - therapeutic use ; Clostridium - immunology ; Clostridium difficile ; Endotoxins - analysis ; Enterocolitis, Pseudomembranous - drug therapy ; Humans ; Inflammation ; Intestinal Diseases - immunology</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1981-04, Vol.80 (4), p.697-700</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-75ffdc83b8f99262c04dbc255c1bbb832ee7119f4d939745ce3255bf66cfcbc3</citedby><cites>FETCH-LOGICAL-c454t-75ffdc83b8f99262c04dbc255c1bbb832ee7119f4d939745ce3255bf66cfcbc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0016-5085(81)90128-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7202942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meyers, S.</creatorcontrib><creatorcontrib>Mayer, L.</creatorcontrib><creatorcontrib>Bottone, E.</creatorcontrib><creatorcontrib>Desmond, E.</creatorcontrib><creatorcontrib>Janowitz, H.D.</creatorcontrib><title>Occurrence of Clostridium difficile toxin during the course of inflammatory bowel disease</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>Clostridium difficile toxin, the presumed mechanism of antibiotic-associated pseudomembranous colitis, has been suggested as a contributory factor to mucosal injury in inflammatory bowel disease. 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We conclude that Clostridium difficile toxin appears only in patients exposed to antimicrobials and is unlikely to be a significant contributory factor in inflammatory bowel disease.</description><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Clostridium - immunology</subject><subject>Clostridium difficile</subject><subject>Endotoxins - analysis</subject><subject>Enterocolitis, Pseudomembranous - drug therapy</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Intestinal Diseases - immunology</subject><issn>0016-5085</issn><issn>1528-0012</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQx4Mouj6-gUJPoodqHk0fF0EWXyB48eIpNJOJRtpGk1bdb2_WXTzqZWbg_xj4EXLI6BmjrDynaeSS1vKkZqcNZbzO2QaZMZmOpPFNMvu17JDdGF8ppY2o2TbZrjjlTcFn5OkBYAoBB8DM22ze-TgGZ9zUZ8ZZ68B1mI3-yw2ZmYIbnrPxBTPwU4g_ATfYru37dvRhkWn_iV3KRWwj7pMt23YRD9Z7jzxeXz3Ob_P7h5u7-eV9DoUsxryS1hqoha5t0_CSAy2MBi4lMK11LThixVhjC9OIpiokoEiitmUJFjSIPXK8qn0L_n3COKreRcCuawf0U1SVlGUlBf_XyKRgXHCajMXKCMHHGNCqt-D6NiwUo2pJXi2xqiVWVTP1Q16xFDta90-6R_MbWqNO-sVKxwTjw2FQEdySu3EBYVTGu78ffAN8dJN1</recordid><startdate>198104</startdate><enddate>198104</enddate><creator>Meyers, S.</creator><creator>Mayer, L.</creator><creator>Bottone, E.</creator><creator>Desmond, E.</creator><creator>Janowitz, H.D.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>198104</creationdate><title>Occurrence of Clostridium difficile toxin during the course of inflammatory bowel disease</title><author>Meyers, S. ; Mayer, L. ; Bottone, E. ; Desmond, E. ; Janowitz, H.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-75ffdc83b8f99262c04dbc255c1bbb832ee7119f4d939745ce3255bf66cfcbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Clostridium - immunology</topic><topic>Clostridium difficile</topic><topic>Endotoxins - analysis</topic><topic>Enterocolitis, Pseudomembranous - drug therapy</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Intestinal Diseases - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meyers, S.</creatorcontrib><creatorcontrib>Mayer, L.</creatorcontrib><creatorcontrib>Bottone, E.</creatorcontrib><creatorcontrib>Desmond, E.</creatorcontrib><creatorcontrib>Janowitz, H.D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meyers, S.</au><au>Mayer, L.</au><au>Bottone, E.</au><au>Desmond, E.</au><au>Janowitz, H.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Occurrence of Clostridium difficile toxin during the course of inflammatory bowel disease</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1981-04</date><risdate>1981</risdate><volume>80</volume><issue>4</issue><spage>697</spage><epage>700</epage><pages>697-700</pages><issn>0016-5085</issn><issn>1528-0012</issn><eissn>1528-0012</eissn><abstract>Clostridium difficile toxin, the presumed mechanism of antibiotic-associated pseudomembranous colitis, has been suggested as a contributory factor to mucosal injury in inflammatory bowel disease. 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| fulltext | fulltext |
| identifier | ISSN: 0016-5085 |
| ispartof | Gastroenterology (New York, N.Y. 1943), 1981-04, Vol.80 (4), p.697-700 |
| issn | 0016-5085 1528-0012 1528-0012 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Alma/SFX Local Collection |
| subjects | Anti-Bacterial Agents - therapeutic use Clostridium - immunology Clostridium difficile Endotoxins - analysis Enterocolitis, Pseudomembranous - drug therapy Humans Inflammation Intestinal Diseases - immunology |
| title | Occurrence of Clostridium difficile toxin during the course of inflammatory bowel disease |
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