Hormone resistance, invasiveness, and metastatic potential in breast cancer

Critical phenotypic changes that occur during the progression of breast cancer include the loss of hormone-dependence, acquired resistance to systemic therapies, and increased metastatic potential. We have isolated a series of MCF-7 human breast cancer variants which exhibit hormone-independent grow...

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Veröffentlicht in:	Breast cancer research and treatment 1993-01, Vol.24 (3), p.227-239
Hauptverfasser:	Clarke, R, Thompson, E W, Leonessa, F, Lippman, J, McGarvey, M, Frandsen, T L, Brünner, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma - drug therapy Carcinoma - genetics Carcinoma - pathology Drug Resistance Estrogen Antagonists - therapeutic use Female Gene Expression Regulation, Neoplastic Hormones - physiology Humans Neoplasm Invasiveness Neoplasm Metastasis Neoplasms, Hormone-Dependent - genetics Phenotype
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