Urinary dopamine response to angiotensin II is not abnormal in type 1 (insulin-dependent) diabetes mellitus
To examine the interaction between angiotensin II (ANGII) and dopamine in type I diabetes mellitus, urinary dopamine excretion was examined during ANGII infusion in 15 diabetic patients and 10 control subjects after pretreatment with lithium 750 mg and placebo. The antinatriuretic response and the u...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 1993, Vol.8 (1), p.36-40 |
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| container_title | Nephrology, dialysis, transplantation |
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| creator | Eadington, D. W. Swainson, C. P. Frier, B. M. Johnston, N. Samson, R. R. Lee, M. R. |
| description | To examine the interaction between angiotensin II (ANGII) and dopamine in type I diabetes mellitus, urinary dopamine excretion was examined during ANGII infusion in 15 diabetic patients and 10 control subjects after pretreatment with lithium 750 mg and placebo. The antinatriuretic response and the urinary dopamine response to ANGII did not differ within or between the two groups on each study day. No correlation was observed between the decrements in urinary sodium excretion and urinary dopamine output during ANGII infusion in either group. The effect of insulin on urinary dopamine excretion was studied separately in seven non-diabetic subjects; sodium and potassium retention occurred during a hyperinsulinaemic euglycaemic clamp, but urinary dopamine did not change. The data suggest that the relationship between urinary sodium excretion and tubular dopamine synthesis remains normal in early type 1 diabetes mellitus both at baseline and during the antinatriuresis induced by angiotensin II. The cause of the reduction in urinary dopamine during ANGII infusion is unclear, but is probably not mediated directly by changes in proximal tubular sodium transport. |
| doi_str_mv | 10.1093/oxfordjournals.ndt.a092268 |
| format | Article |
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W. ; Swainson, C. P. ; Frier, B. M. ; Johnston, N. ; Samson, R. R. ; Lee, M. R.</creator><creatorcontrib>Eadington, D. W. ; Swainson, C. P. ; Frier, B. M. ; Johnston, N. ; Samson, R. R. ; Lee, M. R.</creatorcontrib><description>To examine the interaction between angiotensin II (ANGII) and dopamine in type I diabetes mellitus, urinary dopamine excretion was examined during ANGII infusion in 15 diabetic patients and 10 control subjects after pretreatment with lithium 750 mg and placebo. The antinatriuretic response and the urinary dopamine response to ANGII did not differ within or between the two groups on each study day. No correlation was observed between the decrements in urinary sodium excretion and urinary dopamine output during ANGII infusion in either group. The effect of insulin on urinary dopamine excretion was studied separately in seven non-diabetic subjects; sodium and potassium retention occurred during a hyperinsulinaemic euglycaemic clamp, but urinary dopamine did not change. The data suggest that the relationship between urinary sodium excretion and tubular dopamine synthesis remains normal in early type 1 diabetes mellitus both at baseline and during the antinatriuresis induced by angiotensin II. The cause of the reduction in urinary dopamine during ANGII infusion is unclear, but is probably not mediated directly by changes in proximal tubular sodium transport.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/oxfordjournals.ndt.a092268</identifier><identifier>PMID: 8381932</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; angiotensin II ; Angiotensin II - administration & dosage ; Angiotensin II - pharmacology ; Biological and medical sciences ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetes Mellitus, Type 1 - urine ; Diabetes. Impaired glucose tolerance ; dopamine ; Dopamine - physiology ; Dopamine - urine ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Humans ; Infusions, Intravenous ; Insulin - pharmacology ; Lithium - pharmacokinetics ; lithium clearance ; Male ; Medical sciences ; Natriuresis - drug effects ; Natriuresis - physiology ; Potassium - urine ; sodium ; type 1 diabetes mellitus</subject><ispartof>Nephrology, dialysis, transplantation, 1993, Vol.8 (1), p.36-40</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c296t-e9f1a76dc4bbe301068452e4b03f993c17e38260722032759aeb90c85fe4d1ab3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4533661$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8381932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eadington, D. W.</creatorcontrib><creatorcontrib>Swainson, C. P.</creatorcontrib><creatorcontrib>Frier, B. M.</creatorcontrib><creatorcontrib>Johnston, N.</creatorcontrib><creatorcontrib>Samson, R. R.</creatorcontrib><creatorcontrib>Lee, M. R.</creatorcontrib><title>Urinary dopamine response to angiotensin II is not abnormal in type 1 (insulin-dependent) diabetes mellitus</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>To examine the interaction between angiotensin II (ANGII) and dopamine in type I diabetes mellitus, urinary dopamine excretion was examined during ANGII infusion in 15 diabetic patients and 10 control subjects after pretreatment with lithium 750 mg and placebo. The antinatriuretic response and the urinary dopamine response to ANGII did not differ within or between the two groups on each study day. No correlation was observed between the decrements in urinary sodium excretion and urinary dopamine output during ANGII infusion in either group. The effect of insulin on urinary dopamine excretion was studied separately in seven non-diabetic subjects; sodium and potassium retention occurred during a hyperinsulinaemic euglycaemic clamp, but urinary dopamine did not change. The data suggest that the relationship between urinary sodium excretion and tubular dopamine synthesis remains normal in early type 1 diabetes mellitus both at baseline and during the antinatriuresis induced by angiotensin II. The cause of the reduction in urinary dopamine during ANGII infusion is unclear, but is probably not mediated directly by changes in proximal tubular sodium transport.</description><subject>Adult</subject><subject>angiotensin II</subject><subject>Angiotensin II - administration & dosage</subject><subject>Angiotensin II - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetes Mellitus, Type 1 - urine</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>dopamine</subject><subject>Dopamine - physiology</subject><subject>Dopamine - urine</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Insulin - pharmacology</subject><subject>Lithium - pharmacokinetics</subject><subject>lithium clearance</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Natriuresis - drug effects</subject><subject>Natriuresis - physiology</subject><subject>Potassium - urine</subject><subject>sodium</subject><subject>type 1 diabetes mellitus</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkF1rFDEUhoNY6lr9CUIQEb2YNR-TZNI7KdpdWuhFrYo3ITNzRtLOJGOSgfbfG9lhwasD533OBw9CbynZUqL5p_A4hNjfhyV6O6at7_PWEs2YbJ6hDa0lqRhvxHO0KTCtiCD6BXqZ0j0hhVLqFJ02vKGasw16uIvO2_iE-zDbyXnAEdIcfAKcA7b-twsZfHIe7_fYJexDxrb1IU52xKWbn2bAFH9wPi2j81UPM_gefP6Ie2dbyJDwBOPo8pJeoZOh_Auv13qG7r5--Xaxq65vLvcXn6-rjmmZK9ADtUr2Xd22wAklsqkFg7olfNCad1QBb5gkijHCmRLaQqtJ14gB6p7alp-h94e9cwx_FkjZTC515QnrISzJKCGk0EwX8PwAdjGkFGEwc3RTsWEoMf9Mm_9Nm2LarKbL8Jv1ytJO0B9HV7Ulf7fmNnV2HKL1nUtHrBacS0kLVh0wlzI8HmMbH4xUXAmz-_nL7JpLdsW-_zC3_C9i1p21</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Eadington, D. W.</creator><creator>Swainson, C. P.</creator><creator>Frier, B. M.</creator><creator>Johnston, N.</creator><creator>Samson, R. R.</creator><creator>Lee, M. R.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Urinary dopamine response to angiotensin II is not abnormal in type 1 (insulin-dependent) diabetes mellitus</title><author>Eadington, D. W. ; Swainson, C. P. ; Frier, B. M. ; Johnston, N. ; Samson, R. R. ; Lee, M. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-e9f1a76dc4bbe301068452e4b03f993c17e38260722032759aeb90c85fe4d1ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>angiotensin II</topic><topic>Angiotensin II - administration & dosage</topic><topic>Angiotensin II - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetes Mellitus, Type 1 - urine</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>dopamine</topic><topic>Dopamine - physiology</topic><topic>Dopamine - urine</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Insulin - pharmacology</topic><topic>Lithium - pharmacokinetics</topic><topic>lithium clearance</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Natriuresis - drug effects</topic><topic>Natriuresis - physiology</topic><topic>Potassium - urine</topic><topic>sodium</topic><topic>type 1 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eadington, D. W.</creatorcontrib><creatorcontrib>Swainson, C. P.</creatorcontrib><creatorcontrib>Frier, B. M.</creatorcontrib><creatorcontrib>Johnston, N.</creatorcontrib><creatorcontrib>Samson, R. R.</creatorcontrib><creatorcontrib>Lee, M. R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eadington, D. W.</au><au>Swainson, C. P.</au><au>Frier, B. M.</au><au>Johnston, N.</au><au>Samson, R. R.</au><au>Lee, M. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary dopamine response to angiotensin II is not abnormal in type 1 (insulin-dependent) diabetes mellitus</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>1993</date><risdate>1993</risdate><volume>8</volume><issue>1</issue><spage>36</spage><epage>40</epage><pages>36-40</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>To examine the interaction between angiotensin II (ANGII) and dopamine in type I diabetes mellitus, urinary dopamine excretion was examined during ANGII infusion in 15 diabetic patients and 10 control subjects after pretreatment with lithium 750 mg and placebo. The antinatriuretic response and the urinary dopamine response to ANGII did not differ within or between the two groups on each study day. No correlation was observed between the decrements in urinary sodium excretion and urinary dopamine output during ANGII infusion in either group. The effect of insulin on urinary dopamine excretion was studied separately in seven non-diabetic subjects; sodium and potassium retention occurred during a hyperinsulinaemic euglycaemic clamp, but urinary dopamine did not change. The data suggest that the relationship between urinary sodium excretion and tubular dopamine synthesis remains normal in early type 1 diabetes mellitus both at baseline and during the antinatriuresis induced by angiotensin II. The cause of the reduction in urinary dopamine during ANGII infusion is unclear, but is probably not mediated directly by changes in proximal tubular sodium transport.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8381932</pmid><doi>10.1093/oxfordjournals.ndt.a092268</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult angiotensin II Angiotensin II - administration & dosage Angiotensin II - pharmacology Biological and medical sciences Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - physiopathology Diabetes Mellitus, Type 1 - urine Diabetes. Impaired glucose tolerance dopamine Dopamine - physiology Dopamine - urine Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Humans Infusions, Intravenous Insulin - pharmacology Lithium - pharmacokinetics lithium clearance Male Medical sciences Natriuresis - drug effects Natriuresis - physiology Potassium - urine sodium type 1 diabetes mellitus |
| title | Urinary dopamine response to angiotensin II is not abnormal in type 1 (insulin-dependent) diabetes mellitus |
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