The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition

Previous studies on the role of specific residues of the peptide or MHC molecule in Ag presentation have revealed the sensitivity of this complex system to even small changes in structure. In our study, we have analyzed the effect of amino acid substitution in a major CD4+ T cell determinant (T1) of...

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Veröffentlicht in:	The Journal of immunology (1950) 1993-01, Vol.150 (2), p.331-341
Hauptverfasser:	BOEHNCKE, W.-H, TAKESHITA, T, PENDLETON, C. D, HOUGHTEN, R. A, SADEGH-NASSERI, S, RACIOPPI, L, BERZOFSKY, J. A, GERMAIN, R. N
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Animals Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Products, env - immunology Histocompatibility Antigens Class II - metabolism HIV Envelope Protein gp160 Hybridomas - immunology Immunobiology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Male Mice Mice, Inbred C3H Molecular Sequence Data Peptide Fragments - immunology Peptide Fragments - metabolism Polymorphism, Genetic Protein Precursors - immunology Receptors, Antigen, T-Cell - metabolism Structure-Activity Relationship
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