Incorporation and release of fluorescein isothiocyanate-linked dextrans from a bead-formed macroporous hydrophilic matrix with potential for sustained release
Freeze-thaw polymerization has been used to generate a bead-formed (100–3000 μm) macroporous hydrophilic matrix with potential for the sustained release of macromolecules. While the incorporation of FITC-dextrans marginally increased the equilibrium water content, their in vitro release profiles wer...
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| Veröffentlicht in: | Biomaterials 1993, Vol.14 (1), p.16-20 |
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| container_title | Biomaterials |
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| creator | Atkins, T.W. Tighe, B.J. McCallion, R.L. |
| description | Freeze-thaw polymerization has been used to generate a bead-formed (100–3000 μm) macroporous hydrophilic matrix with potential for the sustained release of macromolecules. While the incorporation of FITC-dextrans marginally increased the equilibrium water content, their
in vitro release profiles were characterized by an initial burst followed by a low but sustained release lasting >21 d. The total cumulative release of FD-150 and the percentage of the incorporated FD-150 load subsequently released were reduced compared with FD-20S but for both dextrans these parameters could be enhanced by increasing the bead size and increasing the incubation temperature to 37°C. |
| doi_str_mv | 10.1016/0142-9612(93)90016-U |
| format | Article |
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in vitro release profiles were characterized by an initial burst followed by a low but sustained release lasting >21 d. The total cumulative release of FD-150 and the percentage of the incorporated FD-150 load subsequently released were reduced compared with FD-20S but for both dextrans these parameters could be enhanced by increasing the bead size and increasing the incubation temperature to 37°C.</description><subject>Biocompatible Materials</subject><subject>Biological and medical sciences</subject><subject>controlled release</subject><subject>Delayed-Action Preparations</subject><subject>Dextrans</subject><subject>FITC-dextrans</subject><subject>Fluorescein-5-isothiocyanate</subject><subject>Freeze-thaw polymerization</subject><subject>macroporous beads</subject><subject>Medical sciences</subject><subject>Microspheres</subject><subject>Molecular Weight</subject><subject>Particle Size</subject><subject>Polyhydroxyethyl Methacrylate - chemistry</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Technology. Biomaterials. Equipments. Material. 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Instrumentation</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atkins, T.W.</creatorcontrib><creatorcontrib>Tighe, B.J.</creatorcontrib><creatorcontrib>McCallion, R.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atkins, T.W.</au><au>Tighe, B.J.</au><au>McCallion, R.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incorporation and release of fluorescein isothiocyanate-linked dextrans from a bead-formed macroporous hydrophilic matrix with potential for sustained release</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>1993</date><risdate>1993</risdate><volume>14</volume><issue>1</issue><spage>16</spage><epage>20</epage><pages>16-20</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Freeze-thaw polymerization has been used to generate a bead-formed (100–3000 μm) macroporous hydrophilic matrix with potential for the sustained release of macromolecules. While the incorporation of FITC-dextrans marginally increased the equilibrium water content, their
in vitro release profiles were characterized by an initial burst followed by a low but sustained release lasting >21 d. The total cumulative release of FD-150 and the percentage of the incorporated FD-150 load subsequently released were reduced compared with FD-20S but for both dextrans these parameters could be enhanced by increasing the bead size and increasing the incubation temperature to 37°C.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>7678754</pmid><doi>10.1016/0142-9612(93)90016-U</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 1993, Vol.14 (1), p.16-20 |
| issn | 0142-9612 1878-5905 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75562727 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biocompatible Materials Biological and medical sciences controlled release Delayed-Action Preparations Dextrans FITC-dextrans Fluorescein-5-isothiocyanate Freeze-thaw polymerization macroporous beads Medical sciences Microspheres Molecular Weight Particle Size Polyhydroxyethyl Methacrylate - chemistry Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Technology. Biomaterials. Equipments. Material. Instrumentation Water |
| title | Incorporation and release of fluorescein isothiocyanate-linked dextrans from a bead-formed macroporous hydrophilic matrix with potential for sustained release |
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