Methionine but not folinic acid or vitamin B-12 alters the frequency of neural tube defects in Axd mutant mice

The Axd (axial defects) mutation, which causes open neural tube defects (NTD) in 25-30% of d 14 mouse embryos of heterozygous (Axd/+) matings and curly tails (CT) in 31%, can be useful in studying neurovertebral morphogenesis. Current interest focuses on the role of methionine in neurulation, becaus...

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Veröffentlicht in:	The Journal of nutrition 1993-01, Vol.123 (1), p.27-34
Hauptverfasser:	Essien, F.B. (Rutgers University, Piscataway, NJ), Wannberg, S.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - blood Animals Biological and medical sciences COMPLEXE VITAMINIQUE B DEFAUT DEFECTOS DIETA Embryo, Mammalian - drug effects Embryology: invertebrates and vertebrates. Teratology Female Folic Acid - administration & dosage Folic Acid - therapeutic use Fundamental and applied biological sciences. Psychology Injections, Intraperitoneal Male METHIONINE Methionine - administration & dosage Methionine - therapeutic use METIONINA Mice Mice, Inbred BALB C Mice, Inbred Strains Mice, Mutant Strains Molecular embryology Neural Tube Defects - prevention & control RATON REGIME ALIMENTAIRE SISTEMA NERVIOSO CENTRAL SOURIS SYSTEME NERVEUX CENTRAL Vitamin B 12 - administration & dosage Vitamin B 12 - therapeutic use VITAMINA B12 VITAMINAS B VITAMINE B12
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