Insulin as a Potent, Specific Growth Factor in a Rat Hepatoma Cell Line
A line of rat hepatoma cells in culture which, in response to serum starvation, become arrested in the early G$_{1}$ phase of growth, can be stimulated by insulin alone to enter the cell cycle and traverse S phase. A half-maximum response is observed at 30 to 70 picomolar concentrations and the maxi...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1981-02, Vol.211 (4485), p.947-949 |
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| container_end_page | 949 |
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| container_issue | 4485 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 211 |
| creator | Koontz, John W. Iwahashi, Mieko |
| description | A line of rat hepatoma cells in culture which, in response to serum starvation, become arrested in the early G$_{1}$ phase of growth, can be stimulated by insulin alone to enter the cell cycle and traverse S phase. A half-maximum response is observed at 30 to 70 picomolar concentrations and the maximum response is essentially identical to that found with optimum serum concentrations. |
| doi_str_mv | 10.1126/science.7008195 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1981-02, Vol.211 (4485), p.947-949 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75559138 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | Amoeba Animals Cell cycle Cell Cycle - drug effects Cell Division - drug effects Cell growth Cell Line Cell lines Cell nucleus Electrodes Growth Substances Human growth Insulin Insulin - pharmacology Interphase Liver Neoplasms, Experimental - pathology Mitosis - drug effects Mitotic index Proinsulin - pharmacology Rats Structure-Activity Relationship |
| title | Insulin as a Potent, Specific Growth Factor in a Rat Hepatoma Cell Line |
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