Peripheral nerves and mast cells in normal buccal mucosa
The topographical distribution and relation to mast cells of PGP 9.5 (protein gene product 9.5. a major cytoplasmic neuron‐specific protein with ubiquitin C‐terminal hydrolase activity) and neurofilament (intermediate neuron‐specific cytoskeletal filaments) in normal human buccal mucosa was studied...
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| Veröffentlicht in: | Journal of oral pathology & medicine 1993-01, Vol.22 (1), p.30-34 |
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| container_title | Journal of oral pathology & medicine |
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| creator | Ruokonen, Hellevi Hietanen, Jarkko Malmström, Maria Sane, Juha Häyrinen-Immonen, Ritva Hukkanen, Mika Konttinen, Yrjö T. |
| description | The topographical distribution and relation to mast cells of PGP 9.5 (protein gene product 9.5. a major cytoplasmic neuron‐specific protein with ubiquitin C‐terminal hydrolase activity) and neurofilament (intermediate neuron‐specific cytoskeletal filaments) in normal human buccal mucosa was studied in five healthy volunteers. Morphometric analysis disclosed the densest innervation to be in the middle layers of the lamina propria, with a mean number of 5.9–6.1 PGP 9.5 and/or neurofilament‐immunoreactive nerve fiber profiles per one mm2. In contrast, the mean mast cell number decreased from 110/mm2 to 46/mm2 from superficial to deep lamina propria, being 69–72/mm2 in the most densely innervated middle layers. Only 16–17% of all fiber profiles contained substance P and 51–54% calcitonin gene‐related peptide (CGRP). Finally, analysis of the spatial relationship between nerve fiber profiles and mast cells in a double staining procedure disclosed no preferential neuron‐effector associations. All these findings suggest that such a relationship does not exist between peripheral nerves and mast cells in normal buccal mucosa. |
| doi_str_mv | 10.1111/j.1600-0714.1993.tb00116.x |
| format | Article |
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Morphometric analysis disclosed the densest innervation to be in the middle layers of the lamina propria, with a mean number of 5.9–6.1 PGP 9.5 and/or neurofilament‐immunoreactive nerve fiber profiles per one mm2. In contrast, the mean mast cell number decreased from 110/mm2 to 46/mm2 from superficial to deep lamina propria, being 69–72/mm2 in the most densely innervated middle layers. Only 16–17% of all fiber profiles contained substance P and 51–54% calcitonin gene‐related peptide (CGRP). Finally, analysis of the spatial relationship between nerve fiber profiles and mast cells in a double staining procedure disclosed no preferential neuron‐effector associations. All these findings suggest that such a relationship does not exist between peripheral nerves and mast cells in normal buccal mucosa.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/j.1600-0714.1993.tb00116.x</identifier><identifier>PMID: 7678295</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Calcitonin Gene-Related Peptide - analysis ; Connective Tissue - innervation ; Dentistry ; Female ; Fundamental and applied biological sciences. Psychology ; Histocytochemistry ; histology ; Humans ; Male ; mast cell ; Mast Cells ; mouth ; Mouth Mucosa - chemistry ; Mouth Mucosa - cytology ; Mouth Mucosa - innervation ; mouth, histology ; Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus ; Nerve Fibers ; nerve peripheral ; Neurofilament Proteins - analysis ; oral mucosa ; Peripheral Nerves - anatomy & histology ; Substance P - analysis ; Thiolester Hydrolases - analysis ; Ubiquitin Thiolesterase ; Vertebrates: digestive system</subject><ispartof>Journal of oral pathology & medicine, 1993-01, Vol.22 (1), p.30-34</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5010-8876f8d912721bd5c2b2709c6995e7faf7abd4fcfe083499fefdb3914240b2243</citedby><cites>FETCH-LOGICAL-c5010-8876f8d912721bd5c2b2709c6995e7faf7abd4fcfe083499fefdb3914240b2243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0714.1993.tb00116.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0714.1993.tb00116.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4546797$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7678295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruokonen, Hellevi</creatorcontrib><creatorcontrib>Hietanen, Jarkko</creatorcontrib><creatorcontrib>Malmström, Maria</creatorcontrib><creatorcontrib>Sane, Juha</creatorcontrib><creatorcontrib>Häyrinen-Immonen, Ritva</creatorcontrib><creatorcontrib>Hukkanen, Mika</creatorcontrib><creatorcontrib>Konttinen, Yrjö T.</creatorcontrib><title>Peripheral nerves and mast cells in normal buccal mucosa</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>The topographical distribution and relation to mast cells of PGP 9.5 (protein gene product 9.5. a major cytoplasmic neuron‐specific protein with ubiquitin C‐terminal hydrolase activity) and neurofilament (intermediate neuron‐specific cytoskeletal filaments) in normal human buccal mucosa was studied in five healthy volunteers. Morphometric analysis disclosed the densest innervation to be in the middle layers of the lamina propria, with a mean number of 5.9–6.1 PGP 9.5 and/or neurofilament‐immunoreactive nerve fiber profiles per one mm2. In contrast, the mean mast cell number decreased from 110/mm2 to 46/mm2 from superficial to deep lamina propria, being 69–72/mm2 in the most densely innervated middle layers. Only 16–17% of all fiber profiles contained substance P and 51–54% calcitonin gene‐related peptide (CGRP). Finally, analysis of the spatial relationship between nerve fiber profiles and mast cells in a double staining procedure disclosed no preferential neuron‐effector associations. All these findings suggest that such a relationship does not exist between peripheral nerves and mast cells in normal buccal mucosa.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Calcitonin Gene-Related Peptide - analysis</subject><subject>Connective Tissue - innervation</subject><subject>Dentistry</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Histocytochemistry</subject><subject>histology</subject><subject>Humans</subject><subject>Male</subject><subject>mast cell</subject><subject>Mast Cells</subject><subject>mouth</subject><subject>Mouth Mucosa - chemistry</subject><subject>Mouth Mucosa - cytology</subject><subject>Mouth Mucosa - innervation</subject><subject>mouth, histology</subject><subject>Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus</subject><subject>Nerve Fibers</subject><subject>nerve peripheral</subject><subject>Neurofilament Proteins - analysis</subject><subject>oral mucosa</subject><subject>Peripheral Nerves - anatomy & histology</subject><subject>Substance P - analysis</subject><subject>Thiolester Hydrolases - analysis</subject><subject>Ubiquitin Thiolesterase</subject><subject>Vertebrates: digestive system</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMlOwzAURS0EgjJ8AlKEELsEj3GMxAJVzBVlwSQ2luPYIiVDsRsof4-jRt3jzVvcc5-fDgBHCCYovNNZglIIY8gRTZAQJFnkECKUJssNMFpHm2AEBaQxZgjvgF3vZwHihKJtsM1TnmHBRiB7NK6cfxinqqgx7tv4SDVFVCu_iLSpKh-VTdS0rg553mkdRt3p1qt9sGVV5c3BMPfA89Xl0_gmnkyvb8cXk1gziGCcZTy1WSEQ5hjlBdM4xxwKnQrBDLfKcpUX1GprYEaoENbYIicCUUxhjjEle-BktXfu2q_O-IWsS99fphrTdl5yxljGMhHAsxWoXeu9M1bOXVkr9ysRlL02OZO9G9m7kb02OWiTy1A-HH7p8toU6-rgKeTHQ658cGCdanTp1xhlNOWCB-x8hf2Ulfn9xwHybvpIYOjHq37pF2a57iv3KVNOOJOvD9cyfSP8Ht29yxfyB58al3o</recordid><startdate>199301</startdate><enddate>199301</enddate><creator>Ruokonen, Hellevi</creator><creator>Hietanen, Jarkko</creator><creator>Malmström, Maria</creator><creator>Sane, Juha</creator><creator>Häyrinen-Immonen, Ritva</creator><creator>Hukkanen, Mika</creator><creator>Konttinen, Yrjö T.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199301</creationdate><title>Peripheral nerves and mast cells in normal buccal mucosa</title><author>Ruokonen, Hellevi ; Hietanen, Jarkko ; Malmström, Maria ; Sane, Juha ; Häyrinen-Immonen, Ritva ; Hukkanen, Mika ; Konttinen, Yrjö T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5010-8876f8d912721bd5c2b2709c6995e7faf7abd4fcfe083499fefdb3914240b2243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Calcitonin Gene-Related Peptide - analysis</topic><topic>Connective Tissue - innervation</topic><topic>Dentistry</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Histocytochemistry</topic><topic>histology</topic><topic>Humans</topic><topic>Male</topic><topic>mast cell</topic><topic>Mast Cells</topic><topic>mouth</topic><topic>Mouth Mucosa - chemistry</topic><topic>Mouth Mucosa - cytology</topic><topic>Mouth Mucosa - innervation</topic><topic>mouth, histology</topic><topic>Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus</topic><topic>Nerve Fibers</topic><topic>nerve peripheral</topic><topic>Neurofilament Proteins - analysis</topic><topic>oral mucosa</topic><topic>Peripheral Nerves - anatomy & histology</topic><topic>Substance P - analysis</topic><topic>Thiolester Hydrolases - analysis</topic><topic>Ubiquitin Thiolesterase</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruokonen, Hellevi</creatorcontrib><creatorcontrib>Hietanen, Jarkko</creatorcontrib><creatorcontrib>Malmström, Maria</creatorcontrib><creatorcontrib>Sane, Juha</creatorcontrib><creatorcontrib>Häyrinen-Immonen, Ritva</creatorcontrib><creatorcontrib>Hukkanen, Mika</creatorcontrib><creatorcontrib>Konttinen, Yrjö T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruokonen, Hellevi</au><au>Hietanen, Jarkko</au><au>Malmström, Maria</au><au>Sane, Juha</au><au>Häyrinen-Immonen, Ritva</au><au>Hukkanen, Mika</au><au>Konttinen, Yrjö T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral nerves and mast cells in normal buccal mucosa</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>1993-01</date><risdate>1993</risdate><volume>22</volume><issue>1</issue><spage>30</spage><epage>34</epage><pages>30-34</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>The topographical distribution and relation to mast cells of PGP 9.5 (protein gene product 9.5. a major cytoplasmic neuron‐specific protein with ubiquitin C‐terminal hydrolase activity) and neurofilament (intermediate neuron‐specific cytoskeletal filaments) in normal human buccal mucosa was studied in five healthy volunteers. Morphometric analysis disclosed the densest innervation to be in the middle layers of the lamina propria, with a mean number of 5.9–6.1 PGP 9.5 and/or neurofilament‐immunoreactive nerve fiber profiles per one mm2. In contrast, the mean mast cell number decreased from 110/mm2 to 46/mm2 from superficial to deep lamina propria, being 69–72/mm2 in the most densely innervated middle layers. Only 16–17% of all fiber profiles contained substance P and 51–54% calcitonin gene‐related peptide (CGRP). Finally, analysis of the spatial relationship between nerve fiber profiles and mast cells in a double staining procedure disclosed no preferential neuron‐effector associations. All these findings suggest that such a relationship does not exist between peripheral nerves and mast cells in normal buccal mucosa.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7678295</pmid><doi>10.1111/j.1600-0714.1993.tb00116.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Calcitonin Gene-Related Peptide - analysis Connective Tissue - innervation Dentistry Female Fundamental and applied biological sciences. Psychology Histocytochemistry histology Humans Male mast cell Mast Cells mouth Mouth Mucosa - chemistry Mouth Mucosa - cytology Mouth Mucosa - innervation mouth, histology Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus Nerve Fibers nerve peripheral Neurofilament Proteins - analysis oral mucosa Peripheral Nerves - anatomy & histology Substance P - analysis Thiolester Hydrolases - analysis Ubiquitin Thiolesterase Vertebrates: digestive system |
| title | Peripheral nerves and mast cells in normal buccal mucosa |
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