Gene Injection Into Canine Myocardium as a Useful Model for Studying Gene Expression in the Heart of Large Mammals

We have investigated the regulated expression of genes injected into the heart of large mammals in situ. Reporter constructs using the chloramphenicol acetyltransferase gene under the control of muscle-specific β-myosin heavy chain (β-MHC) or promiscuous (mouse sarcoma virus) promoters were injected...

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Veröffentlicht in:	Circulation research 1993-03, Vol.72 (3), p.688-695
Hauptverfasser:	Harsdorf, Rüdiger von, Schott, Robert J, Shen, You-Tang, Vatner, Stephen F, Mahdavi, Vijak, Nadal-Ginard, Bernardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chloramphenicol O-Acetyltransferase - genetics DNA Dogs Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genetic Techniques Heart Male Microinjections Myocardium - metabolism Myosins - genetics Space life sciences Vertebrates: cardiovascular system
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