The evidence of platelet activation in bronchial asthma
The possible involvement of platelets in bronchial asthma was investigated under three different conditions: (1) chronic asthma, (2) bronchial provocation inhaling house dust mite (HDM), and (3) status asthmaticus. Plasma levels of β-thromboglobulin (β-TG), platelet factor 4 (PF4), and in part, plat...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 1993, Vol.91 (1), p.79-87 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Yamamoto, Hideaki Nagata, Makoto Tabe, Kazuaki Kimura, Isao Kiuchi, Hidenori Sakamoto, Yoshio Yamamoto, Keiichiro Dohi, Yutaka |
| description | The possible involvement of platelets in bronchial asthma was investigated under three different conditions: (1) chronic asthma, (2) bronchial provocation inhaling house dust mite (HDM), and (3) status asthmaticus. Plasma levels of β-thromboglobulin (β-TG), platelet factor 4 (PF4), and in part, platelet-activating factor (PAF) were measured. Approximately one third of the subjects with symptomatic or asymptomatic chronic asthma showed an increased level of β-TG or PF4. Statistically significant differences occurred in β-TG and PF4 levels only between healthy controls and symptomatic subjects. Five out of six subjects showed no elevation of β-TG and PF4 during immediate asthmatic response. In two out of nine subjects with status asthmaticus, β-TG or PF4 was elevated, and statistically significant correlations occurred between the initial level of PAF and that of β-TG or PF4. Those results suggest that the platelet activation in the circulation is sometimes provoked in asthma, but plasma level of α-granule—derived proteins does not reflect the intensity or severity of asthma, and that PAF is likely to be a mediator responsible for the platelet activation. |
| doi_str_mv | 10.1016/0091-6749(93)90299-U |
| format | Article |
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Plasma levels of β-thromboglobulin (β-TG), platelet factor 4 (PF4), and in part, platelet-activating factor (PAF) were measured. Approximately one third of the subjects with symptomatic or asymptomatic chronic asthma showed an increased level of β-TG or PF4. Statistically significant differences occurred in β-TG and PF4 levels only between healthy controls and symptomatic subjects. Five out of six subjects showed no elevation of β-TG and PF4 during immediate asthmatic response. In two out of nine subjects with status asthmaticus, β-TG or PF4 was elevated, and statistically significant correlations occurred between the initial level of PAF and that of β-TG or PF4. Those results suggest that the platelet activation in the circulation is sometimes provoked in asthma, but plasma level of α-granule—derived proteins does not reflect the intensity or severity of asthma, and that PAF is likely to be a mediator responsible for the platelet activation.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/0091-6749(93)90299-U</identifier><identifier>PMID: 8423274</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Allergic diseases ; Asthma - blood ; Asthma - epidemiology ; beta-Thromboglobulin - analysis ; Biological and medical sciences ; Bronchial asthma ; Bronchial Provocation Tests - methods ; Chronic Disease ; Female ; Humans ; Immunopathology ; Least-Squares Analysis ; Male ; Medical sciences ; Middle Aged ; Platelet Activating Factor - analysis ; Platelet Activation ; platelet factor 4 ; Platelet Factor 4 - analysis ; platelet-activating factor ; Respiratory and ent allergic diseases ; Status Asthmaticus - blood ; Status Asthmaticus - epidemiology ; β-thromboglobulin</subject><ispartof>Journal of allergy and clinical immunology, 1993, Vol.91 (1), p.79-87</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-85e19f9febfa41b0b7628f9a79b5cdd715559426156543e12dd4b49f0c9259293</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/009167499390299U$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,4009,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4603427$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8423274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamamoto, Hideaki</creatorcontrib><creatorcontrib>Nagata, Makoto</creatorcontrib><creatorcontrib>Tabe, Kazuaki</creatorcontrib><creatorcontrib>Kimura, Isao</creatorcontrib><creatorcontrib>Kiuchi, Hidenori</creatorcontrib><creatorcontrib>Sakamoto, Yoshio</creatorcontrib><creatorcontrib>Yamamoto, Keiichiro</creatorcontrib><creatorcontrib>Dohi, Yutaka</creatorcontrib><title>The evidence of platelet activation in bronchial asthma</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>The possible involvement of platelets in bronchial asthma was investigated under three different conditions: (1) chronic asthma, (2) bronchial provocation inhaling house dust mite (HDM), and (3) status asthmaticus. Plasma levels of β-thromboglobulin (β-TG), platelet factor 4 (PF4), and in part, platelet-activating factor (PAF) were measured. Approximately one third of the subjects with symptomatic or asymptomatic chronic asthma showed an increased level of β-TG or PF4. Statistically significant differences occurred in β-TG and PF4 levels only between healthy controls and symptomatic subjects. Five out of six subjects showed no elevation of β-TG and PF4 during immediate asthmatic response. In two out of nine subjects with status asthmaticus, β-TG or PF4 was elevated, and statistically significant correlations occurred between the initial level of PAF and that of β-TG or PF4. Those results suggest that the platelet activation in the circulation is sometimes provoked in asthma, but plasma level of α-granule—derived proteins does not reflect the intensity or severity of asthma, and that PAF is likely to be a mediator responsible for the platelet activation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergic diseases</subject><subject>Asthma - blood</subject><subject>Asthma - epidemiology</subject><subject>beta-Thromboglobulin - analysis</subject><subject>Biological and medical sciences</subject><subject>Bronchial asthma</subject><subject>Bronchial Provocation Tests - methods</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Least-Squares Analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Platelet Activating Factor - analysis</subject><subject>Platelet Activation</subject><subject>platelet factor 4</subject><subject>Platelet Factor 4 - analysis</subject><subject>platelet-activating factor</subject><subject>Respiratory and ent allergic diseases</subject><subject>Status Asthmaticus - blood</subject><subject>Status Asthmaticus - epidemiology</subject><subject>β-thromboglobulin</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMouq7-A4UeRPRQTdJ8dC6CiF8geHHPIU0nbKTbrkl3wX9v6y571NMwzPO-DA8hZ4zeMMrULaXAcqUFXEFxDZQD5LM9MmEUdK5KLvfJZIcckeOUPumwFyUcksNS8IJrMSH6Y44ZrkONrcOs89mysT022GfW9WFt-9C1WWizKnatmwfbZDb184U9IQfeNglPt3NKZk-PHw8v-dv78-vD_VvuRFn0eSmRgQePlbeCVbTSipcerIZKurrWTEoJgismlRQFMl7XohLgqQMugUMxJZeb3mXsvlaYerMIyWHT2Ba7VTJ6KBBK6n9BpjTnUogBFBvQxS6liN4sY1jY-G0YNaNYM1ozozUDhfkVa2ZD7Hzbv6oWWO9CW5PD_WJ7t8nZxkfbupB2mFC0EHx8826D4SBtHTCa5MLovg4RXW_qLvz9xw8yw5K8</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Yamamoto, Hideaki</creator><creator>Nagata, Makoto</creator><creator>Tabe, Kazuaki</creator><creator>Kimura, Isao</creator><creator>Kiuchi, Hidenori</creator><creator>Sakamoto, Yoshio</creator><creator>Yamamoto, Keiichiro</creator><creator>Dohi, Yutaka</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>The evidence of platelet activation in bronchial asthma</title><author>Yamamoto, Hideaki ; Nagata, Makoto ; Tabe, Kazuaki ; Kimura, Isao ; Kiuchi, Hidenori ; Sakamoto, Yoshio ; Yamamoto, Keiichiro ; Dohi, Yutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-85e19f9febfa41b0b7628f9a79b5cdd715559426156543e12dd4b49f0c9259293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergic diseases</topic><topic>Asthma - blood</topic><topic>Asthma - epidemiology</topic><topic>beta-Thromboglobulin - analysis</topic><topic>Biological and medical sciences</topic><topic>Bronchial asthma</topic><topic>Bronchial Provocation Tests - methods</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Least-Squares Analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Platelet Activating Factor - analysis</topic><topic>Platelet Activation</topic><topic>platelet factor 4</topic><topic>Platelet Factor 4 - analysis</topic><topic>platelet-activating factor</topic><topic>Respiratory and ent allergic diseases</topic><topic>Status Asthmaticus - blood</topic><topic>Status Asthmaticus - epidemiology</topic><topic>β-thromboglobulin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamoto, Hideaki</creatorcontrib><creatorcontrib>Nagata, Makoto</creatorcontrib><creatorcontrib>Tabe, Kazuaki</creatorcontrib><creatorcontrib>Kimura, Isao</creatorcontrib><creatorcontrib>Kiuchi, Hidenori</creatorcontrib><creatorcontrib>Sakamoto, Yoshio</creatorcontrib><creatorcontrib>Yamamoto, Keiichiro</creatorcontrib><creatorcontrib>Dohi, Yutaka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamoto, Hideaki</au><au>Nagata, Makoto</au><au>Tabe, Kazuaki</au><au>Kimura, Isao</au><au>Kiuchi, Hidenori</au><au>Sakamoto, Yoshio</au><au>Yamamoto, Keiichiro</au><au>Dohi, Yutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The evidence of platelet activation in bronchial asthma</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>1993</date><risdate>1993</risdate><volume>91</volume><issue>1</issue><spage>79</spage><epage>87</epage><pages>79-87</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>The possible involvement of platelets in bronchial asthma was investigated under three different conditions: (1) chronic asthma, (2) bronchial provocation inhaling house dust mite (HDM), and (3) status asthmaticus. Plasma levels of β-thromboglobulin (β-TG), platelet factor 4 (PF4), and in part, platelet-activating factor (PAF) were measured. Approximately one third of the subjects with symptomatic or asymptomatic chronic asthma showed an increased level of β-TG or PF4. Statistically significant differences occurred in β-TG and PF4 levels only between healthy controls and symptomatic subjects. Five out of six subjects showed no elevation of β-TG and PF4 during immediate asthmatic response. In two out of nine subjects with status asthmaticus, β-TG or PF4 was elevated, and statistically significant correlations occurred between the initial level of PAF and that of β-TG or PF4. Those results suggest that the platelet activation in the circulation is sometimes provoked in asthma, but plasma level of α-granule—derived proteins does not reflect the intensity or severity of asthma, and that PAF is likely to be a mediator responsible for the platelet activation.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>8423274</pmid><doi>10.1016/0091-6749(93)90299-U</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of allergy and clinical immunology, 1993, Vol.91 (1), p.79-87 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Allergic diseases Asthma - blood Asthma - epidemiology beta-Thromboglobulin - analysis Biological and medical sciences Bronchial asthma Bronchial Provocation Tests - methods Chronic Disease Female Humans Immunopathology Least-Squares Analysis Male Medical sciences Middle Aged Platelet Activating Factor - analysis Platelet Activation platelet factor 4 Platelet Factor 4 - analysis platelet-activating factor Respiratory and ent allergic diseases Status Asthmaticus - blood Status Asthmaticus - epidemiology β-thromboglobulin |
| title | The evidence of platelet activation in bronchial asthma |
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