Resistance to Tetracycline, a Hydrophilic Antibiotic, Is Mediated by P-Glycoprotein in Human Multidrug-Resistant Cells

Two multidrug-resistant human leukemic CCRF-CEM sublines (CEM/VCR R and CEM/VLB100) were significantly more resistant to tetracycline, a hydrophilic antibiotic, than parental cells (P < 0.001). Verapamil and cyclosporin A completely reversed tetracycline resistance in CEM/VCR R cells, which also...

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Veröffentlicht in:	Biochemical and biophysical research communications 1993-01, Vol.190 (1), p.79-85
Hauptverfasser:	Kavallaris, M., Madafiglio, J., Norris, M.D., Haber, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP-Binding Cassette, Sub-Family B, Member 1 Biological Transport CCRF-CEM cells Cell Membrane - drug effects Cell Membrane - metabolism Cell Survival - drug effects Cyclosporine - pharmacology Drug Resistance - physiology Humans leukemia man mediation Membrane Glycoproteins - physiology multidrug resistance P-glycoprotein tetracycline Tetracycline - metabolism Tetracycline - pharmacology Tetracycline Resistance - physiology Tumor Cells, Cultured Verapamil - pharmacology Vincristine - metabolism
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