Effect of nonisotonic solutions on tear film osmolality
We found that the original osmolality of the tear film is regained rapidly subsequent to the installation of hypotonic artificial tears or other nonisotonic solutions. The minor irritation due to nonisotonicity and the increased tear volume both contribute to the increased turnover rate which in tur...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 1981-02, Vol.20 (2), p.236-245 |
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| container_title | Investigative ophthalmology & visual science |
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| creator | Holly, F J Lamberts, D W |
| description | We found that the original osmolality of the tear film is regained rapidly subsequent to the installation of hypotonic artificial tears or other nonisotonic solutions. The minor irritation due to nonisotonicity and the increased tear volume both contribute to the increased turnover rate which in turn results in the short half-life (measured in seconds) of these solutions in the eye. Despite the expected fluctuation in tear volume and probably in tear secretion rate during the experiment, the osmolality of the tears followed an exponential decay with relatively good correlation. |
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The minor irritation due to nonisotonicity and the increased tear volume both contribute to the increased turnover rate which in turn results in the short half-life (measured in seconds) of these solutions in the eye. Despite the expected fluctuation in tear volume and probably in tear secretion rate during the experiment, the osmolality of the tears followed an exponential decay with relatively good correlation.</description><identifier>ISSN: 0146-0404</identifier><identifier>PMID: 7461925</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Female ; Humans ; Hypotonic Solutions - pharmacology ; Male ; Models, Biological ; Ophthalmic Solutions - pharmacology ; Osmolar Concentration ; Saline Solution, Hypertonic - pharmacology ; Secretory Rate - drug effects ; Sodium Chloride - pharmacology ; Tears - drug effects ; Tears - secretion ; Time Factors</subject><ispartof>Investigative ophthalmology & visual science, 1981-02, Vol.20 (2), p.236-245</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7461925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holly, F J</creatorcontrib><creatorcontrib>Lamberts, D W</creatorcontrib><title>Effect of nonisotonic solutions on tear film osmolality</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>We found that the original osmolality of the tear film is regained rapidly subsequent to the installation of hypotonic artificial tears or other nonisotonic solutions. The minor irritation due to nonisotonicity and the increased tear volume both contribute to the increased turnover rate which in turn results in the short half-life (measured in seconds) of these solutions in the eye. Despite the expected fluctuation in tear volume and probably in tear secretion rate during the experiment, the osmolality of the tears followed an exponential decay with relatively good correlation.</description><subject>Adult</subject><subject>Female</subject><subject>Humans</subject><subject>Hypotonic Solutions - pharmacology</subject><subject>Male</subject><subject>Models, Biological</subject><subject>Ophthalmic Solutions - pharmacology</subject><subject>Osmolar Concentration</subject><subject>Saline Solution, Hypertonic - pharmacology</subject><subject>Secretory Rate - drug effects</subject><subject>Sodium Chloride - pharmacology</subject><subject>Tears - drug effects</subject><subject>Tears - secretion</subject><subject>Time Factors</subject><issn>0146-0404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj71qwzAYRTW0pGmaRyho6mb49G-PJaQ_EOjSzuazLIGCbLmWPOTta6iXe4Z7uHDvyB6Y1BVIkA_kMecrAGeMw47sjNSs4WpPzNl7ZwtNno5pDDmVNS3NKS4lpDHTNNLicKY-xIGmPKSIMZTbE7n3GLM7bjyQn7fz9-mjuny9f55eL9XEOCtVp4wAVYNnoqttrWxveGd445nrpe9gbW2tNaIFhRwRpMPVdr3uUQumxYG8_O9Oc_pdXC7tELJ1MeLo0pJbo5RsmGlW8XkTl25wfTvNYcD51m5PxR_5CE5p</recordid><startdate>198102</startdate><enddate>198102</enddate><creator>Holly, F J</creator><creator>Lamberts, D W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198102</creationdate><title>Effect of nonisotonic solutions on tear film osmolality</title><author>Holly, F J ; Lamberts, D W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p121t-b5730580f13b8c85cd72b729f1ed4fb0730c866aac05a2aa04ea80fed6da63163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adult</topic><topic>Female</topic><topic>Humans</topic><topic>Hypotonic Solutions - pharmacology</topic><topic>Male</topic><topic>Models, Biological</topic><topic>Ophthalmic Solutions - pharmacology</topic><topic>Osmolar Concentration</topic><topic>Saline Solution, Hypertonic - pharmacology</topic><topic>Secretory Rate - drug effects</topic><topic>Sodium Chloride - pharmacology</topic><topic>Tears - drug effects</topic><topic>Tears - secretion</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holly, F J</creatorcontrib><creatorcontrib>Lamberts, D W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holly, F J</au><au>Lamberts, D W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of nonisotonic solutions on tear film osmolality</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>1981-02</date><risdate>1981</risdate><volume>20</volume><issue>2</issue><spage>236</spage><epage>245</epage><pages>236-245</pages><issn>0146-0404</issn><abstract>We found that the original osmolality of the tear film is regained rapidly subsequent to the installation of hypotonic artificial tears or other nonisotonic solutions. The minor irritation due to nonisotonicity and the increased tear volume both contribute to the increased turnover rate which in turn results in the short half-life (measured in seconds) of these solutions in the eye. Despite the expected fluctuation in tear volume and probably in tear secretion rate during the experiment, the osmolality of the tears followed an exponential decay with relatively good correlation.</abstract><cop>United States</cop><pmid>7461925</pmid><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-0404 |
| ispartof | Investigative ophthalmology & visual science, 1981-02, Vol.20 (2), p.236-245 |
| issn | 0146-0404 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Female Humans Hypotonic Solutions - pharmacology Male Models, Biological Ophthalmic Solutions - pharmacology Osmolar Concentration Saline Solution, Hypertonic - pharmacology Secretory Rate - drug effects Sodium Chloride - pharmacology Tears - drug effects Tears - secretion Time Factors |
| title | Effect of nonisotonic solutions on tear film osmolality |
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