Blockade of endogenous opiates reduces activity in the rat
Naloxone (2 mg/kg, SC) was found to result in a substantial and significant reduction in general activity levels in the rat (90–120 days old). This effect was seen both under baseline conditions and after stress manipulations which would be expected to result in elevated levels of endogenous opiate...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1981, Vol.14 (1), p.113-116 |
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| container_end_page | 116 |
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| container_issue | 1 |
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| container_title | Pharmacology, biochemistry and behavior |
| container_volume | 14 |
| creator | Michael Walker, J. Berntson, Gary G. Paulucci, Thomas S. Champney, Timothy C. |
| description | Naloxone (2 mg/kg, SC) was found to result in a substantial and significant reduction in general activity levels in the rat (90–120 days old). This effect was seen both under baseline conditions and after stress manipulations which would be expected to result in elevated levels of endogenous opiate peptides. Thus, under baseline conditions general activity was reduced to less than half of the saline control value thirty min after injection. Similarly, a reduction was seen after stress induced by a 30 min swim. While naloxone may have some non-opiate effects, these results support the view that endogenous opiate systems may play an important activational role in behavioral regulation, under baseline conditions and conditions of stress. |
| doi_str_mv | 10.1016/0091-3057(81)90112-X |
| format | Article |
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This effect was seen both under baseline conditions and after stress manipulations which would be expected to result in elevated levels of endogenous opiate peptides. Thus, under baseline conditions general activity was reduced to less than half of the saline control value thirty min after injection. Similarly, a reduction was seen after stress induced by a 30 min swim. While naloxone may have some non-opiate effects, these results support the view that endogenous opiate systems may play an important activational role in behavioral regulation, under baseline conditions and conditions of stress.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(81)90112-X</identifier><identifier>PMID: 7465604</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Depression, Chemical ; Endorphins ; Endorphins - antagonists & inhibitors ; Female ; Male ; Motor Activity - drug effects ; Naloxone ; Naloxone - pharmacology ; Rats ; Stress ; Swimming ; Temperature ; Time Factors</subject><ispartof>Pharmacology, biochemistry and behavior, 1981, Vol.14 (1), p.113-116</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-7dc1075cfd592dd4ddd39f729e3550ae6950f7cd475ef4e5c5e0a0c4884a5c003</citedby><cites>FETCH-LOGICAL-c357t-7dc1075cfd592dd4ddd39f729e3550ae6950f7cd475ef4e5c5e0a0c4884a5c003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-3057(81)90112-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7465604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Michael Walker, J.</creatorcontrib><creatorcontrib>Berntson, Gary G.</creatorcontrib><creatorcontrib>Paulucci, Thomas S.</creatorcontrib><creatorcontrib>Champney, Timothy C.</creatorcontrib><title>Blockade of endogenous opiates reduces activity in the rat</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Naloxone (2 mg/kg, SC) was found to result in a substantial and significant reduction in general activity levels in the rat (90–120 days old). 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While naloxone may have some non-opiate effects, these results support the view that endogenous opiate systems may play an important activational role in behavioral regulation, under baseline conditions and conditions of stress.</description><subject>Animals</subject><subject>Depression, Chemical</subject><subject>Endorphins</subject><subject>Endorphins - antagonists & inhibitors</subject><subject>Female</subject><subject>Male</subject><subject>Motor Activity - drug effects</subject><subject>Naloxone</subject><subject>Naloxone - pharmacology</subject><subject>Rats</subject><subject>Stress</subject><subject>Swimming</subject><subject>Temperature</subject><subject>Time Factors</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhC0EKqXwBiDlhOAQWCd2nHCoBBV_UiUuIPVmGXsDhjQutlOpb09Kqx45zWFmZ3c_Qk4pXFGgxTVARdMcuLgo6WUFlGbpbI8MaSnylFMh9slwFzkkRyF8AQDLCjEgA8EKXgAbkpu7xulvZTBxdYKtcR_Yui4kbmFVxJB4NJ3uVelolzauEtsm8RMTr-IxOahVE_BkqyPy9nD_OnlKpy-Pz5PbaapzLmIqjKYguK4NrzJjmDEmr2qRVZhzDgqLikMttGGCY82Qa46gQLOyZIprgHxEzje9C-9-OgxRzm3Q2DSqxf5UKThnooCiD7JNUHsXgsdaLrydK7-SFOQamVzzkGsesqTyD5mc9WNn2_7ufY5mN7Rl1PvjjY_9k0uLXgZtsdVorEcdpXH2_wW_vMN6hg</recordid><startdate>1981</startdate><enddate>1981</enddate><creator>Michael Walker, J.</creator><creator>Berntson, Gary G.</creator><creator>Paulucci, Thomas S.</creator><creator>Champney, Timothy C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1981</creationdate><title>Blockade of endogenous opiates reduces activity in the rat</title><author>Michael Walker, J. ; Berntson, Gary G. ; Paulucci, Thomas S. ; Champney, Timothy C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-7dc1075cfd592dd4ddd39f729e3550ae6950f7cd475ef4e5c5e0a0c4884a5c003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Depression, Chemical</topic><topic>Endorphins</topic><topic>Endorphins - antagonists & inhibitors</topic><topic>Female</topic><topic>Male</topic><topic>Motor Activity - drug effects</topic><topic>Naloxone</topic><topic>Naloxone - pharmacology</topic><topic>Rats</topic><topic>Stress</topic><topic>Swimming</topic><topic>Temperature</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Michael Walker, J.</creatorcontrib><creatorcontrib>Berntson, Gary G.</creatorcontrib><creatorcontrib>Paulucci, Thomas S.</creatorcontrib><creatorcontrib>Champney, Timothy C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Michael Walker, J.</au><au>Berntson, Gary G.</au><au>Paulucci, Thomas S.</au><au>Champney, Timothy C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blockade of endogenous opiates reduces activity in the rat</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1981</date><risdate>1981</risdate><volume>14</volume><issue>1</issue><spage>113</spage><epage>116</epage><pages>113-116</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><abstract>Naloxone (2 mg/kg, SC) was found to result in a substantial and significant reduction in general activity levels in the rat (90–120 days old). 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| fulltext | fulltext |
| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 1981, Vol.14 (1), p.113-116 |
| issn | 0091-3057 1873-5177 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Depression, Chemical Endorphins Endorphins - antagonists & inhibitors Female Male Motor Activity - drug effects Naloxone Naloxone - pharmacology Rats Stress Swimming Temperature Time Factors |
| title | Blockade of endogenous opiates reduces activity in the rat |
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