Effects of a Glucoside-Hydrolase Inhibitor (Bay g 5421) on Serum Lipids, Lipoproteins and Bile Acids, Fecal Fat and Bacterial Flora, and Intestinal Gas Production in Hyperlipidemic Patients
Significant decrease in serum very low density lipoproteins and low density lipoproteins was observed after Bay g 5421 trial (300mg/day for 6 weeks) in 14 hyperlipidemic patients. Although no significant changes were demonstrated in serum fractions of bile acids, the alteration in the patterns of fe...
Gespeichert in:
| Veröffentlicht in: | The Tohoku Journal of Experimental Medicine 1980, Vol.132(4), pp.453-462 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 462 |
|---|---|
| container_issue | 4 |
| container_start_page | 453 |
| container_title | The Tohoku Journal of Experimental Medicine |
| container_volume | 132 |
| creator | MARUHAMA, YOSHISUKE NAGASAKI, AKIO KANAZAWA, YOSHIHIKO HIRAKAWA, HIDENORI GOTO, YOSHIO NISHIYAMA, HIROCHIKA KISHIMOTO, YOSHIMI SHIMOYAMA, TAKASHI |
| description | Significant decrease in serum very low density lipoproteins and low density lipoproteins was observed after Bay g 5421 trial (300mg/day for 6 weeks) in 14 hyperlipidemic patients. Although no significant changes were demonstrated in serum fractions of bile acids, the alteration in the patterns of fecal bacterial flora including the increase in obligate anaerobes was observed after the trial and this was accompanied by the increase in fecal fat excretion. Thus, the possible change in the intestinal bile acid metabolism with the altered flora may lead to an increased catabolism of cholesterol and to the reduction of serum low density lipoproteins. The meteorism developed in several patients but its etiology was shown to be independent of the patterns of the pre-trial bacterial flora and diet composition. |
| doi_str_mv | 10.1620/tjem.132.453 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75547185</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75547185</sourcerecordid><originalsourceid>FETCH-LOGICAL-c579t-b17abc4a6b0a0035e9b76cd4294fa911624d2c8290dac2656c4812b994f6697e3</originalsourceid><addsrcrecordid>eNo9kc2K2zAUhUXpMM1Mu-u2oFVpIU4lWbai5cww-YFAB9quzbV8PaNgW6kkL_JwfbfKSchGF853OJLuIeQzZwteCvYj7rFf8FwsZJG_IzOeS53ludDvyYwxybKlEuoDuQthz1gumSpvya0SRZnkGfn33LZoYqCupUDX3WhcsA1mm2PjXQcB6XZ4s7WNztNvj3Ckr7SQgn-nbqC_0I893dmDbcJ8mu7gXUQ7BApDQx9th_TBnOAKDXR0BfFMwET0dlI652F-ErdDxBDtkNQ1BPriXTOaaNM9dqCb4wF9N92EvTX0BaLFIYaP5KaFLuCny7wnf1bPv5822e7nevv0sMtMoXTMaq6gNhLKmkHaQYG6VqVppNCyBc3TFmUjzFJo1oARZVEaueSi1gmXpVaY35Ov59z0wb9jembV22Cw62BAN4ZKFYVUfFkk4_xsNN6F4LGtDt724I8VZ9XUVjW1VaW2qtRWsn-55I51j83VfKkn8dWZ70OEV7xy8NGaDk9hXKfUU-DlTMFXg3kDX-GQ_weJBamk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75547185</pqid></control><display><type>article</type><title>Effects of a Glucoside-Hydrolase Inhibitor (Bay g 5421) on Serum Lipids, Lipoproteins and Bile Acids, Fecal Fat and Bacterial Flora, and Intestinal Gas Production in Hyperlipidemic Patients</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>MARUHAMA, YOSHISUKE ; NAGASAKI, AKIO ; KANAZAWA, YOSHIHIKO ; HIRAKAWA, HIDENORI ; GOTO, YOSHIO ; NISHIYAMA, HIROCHIKA ; KISHIMOTO, YOSHIMI ; SHIMOYAMA, TAKASHI</creator><creatorcontrib>MARUHAMA, YOSHISUKE ; NAGASAKI, AKIO ; KANAZAWA, YOSHIHIKO ; HIRAKAWA, HIDENORI ; GOTO, YOSHIO ; NISHIYAMA, HIROCHIKA ; KISHIMOTO, YOSHIMI ; SHIMOYAMA, TAKASHI</creatorcontrib><description>Significant decrease in serum very low density lipoproteins and low density lipoproteins was observed after Bay g 5421 trial (300mg/day for 6 weeks) in 14 hyperlipidemic patients. Although no significant changes were demonstrated in serum fractions of bile acids, the alteration in the patterns of fecal bacterial flora including the increase in obligate anaerobes was observed after the trial and this was accompanied by the increase in fecal fat excretion. Thus, the possible change in the intestinal bile acid metabolism with the altered flora may lead to an increased catabolism of cholesterol and to the reduction of serum low density lipoproteins. The meteorism developed in several patients but its etiology was shown to be independent of the patterns of the pre-trial bacterial flora and diet composition.</description><identifier>ISSN: 0040-8727</identifier><identifier>EISSN: 1349-3329</identifier><identifier>DOI: 10.1620/tjem.132.453</identifier><identifier>PMID: 7256727</identifier><language>eng</language><publisher>Japan: Tohoku University Medical Press</publisher><subject>Acarbose ; Adolescent ; Adult ; Aged ; bile acids ; Bile Acids and Salts - blood ; Body Weight - drug effects ; Drug Evaluation ; Fats - analysis ; fecal flora ; Feces - analysis ; Feces - microbiology ; Female ; Gases ; glucoside-hydrolase inhibitor ; Humans ; Hyperlipidemias - blood ; Intestines - physiopathology ; Lipids - blood ; Lipoproteins - blood ; Male ; meteorism ; Middle Aged ; Oligosaccharides - pharmacology ; serum lipoproteins ; Trisaccharides - pharmacology</subject><ispartof>The Tohoku Journal of Experimental Medicine, 1980, Vol.132(4), pp.453-462</ispartof><rights>Tohoku University Medical Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c579t-b17abc4a6b0a0035e9b76cd4294fa911624d2c8290dac2656c4812b994f6697e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7256727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MARUHAMA, YOSHISUKE</creatorcontrib><creatorcontrib>NAGASAKI, AKIO</creatorcontrib><creatorcontrib>KANAZAWA, YOSHIHIKO</creatorcontrib><creatorcontrib>HIRAKAWA, HIDENORI</creatorcontrib><creatorcontrib>GOTO, YOSHIO</creatorcontrib><creatorcontrib>NISHIYAMA, HIROCHIKA</creatorcontrib><creatorcontrib>KISHIMOTO, YOSHIMI</creatorcontrib><creatorcontrib>SHIMOYAMA, TAKASHI</creatorcontrib><title>Effects of a Glucoside-Hydrolase Inhibitor (Bay g 5421) on Serum Lipids, Lipoproteins and Bile Acids, Fecal Fat and Bacterial Flora, and Intestinal Gas Production in Hyperlipidemic Patients</title><title>The Tohoku Journal of Experimental Medicine</title><addtitle>Tohoku J. Exp. Med.</addtitle><description>Significant decrease in serum very low density lipoproteins and low density lipoproteins was observed after Bay g 5421 trial (300mg/day for 6 weeks) in 14 hyperlipidemic patients. Although no significant changes were demonstrated in serum fractions of bile acids, the alteration in the patterns of fecal bacterial flora including the increase in obligate anaerobes was observed after the trial and this was accompanied by the increase in fecal fat excretion. Thus, the possible change in the intestinal bile acid metabolism with the altered flora may lead to an increased catabolism of cholesterol and to the reduction of serum low density lipoproteins. The meteorism developed in several patients but its etiology was shown to be independent of the patterns of the pre-trial bacterial flora and diet composition.</description><subject>Acarbose</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>bile acids</subject><subject>Bile Acids and Salts - blood</subject><subject>Body Weight - drug effects</subject><subject>Drug Evaluation</subject><subject>Fats - analysis</subject><subject>fecal flora</subject><subject>Feces - analysis</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Gases</subject><subject>glucoside-hydrolase inhibitor</subject><subject>Humans</subject><subject>Hyperlipidemias - blood</subject><subject>Intestines - physiopathology</subject><subject>Lipids - blood</subject><subject>Lipoproteins - blood</subject><subject>Male</subject><subject>meteorism</subject><subject>Middle Aged</subject><subject>Oligosaccharides - pharmacology</subject><subject>serum lipoproteins</subject><subject>Trisaccharides - pharmacology</subject><issn>0040-8727</issn><issn>1349-3329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc2K2zAUhUXpMM1Mu-u2oFVpIU4lWbai5cww-YFAB9quzbV8PaNgW6kkL_JwfbfKSchGF853OJLuIeQzZwteCvYj7rFf8FwsZJG_IzOeS53ludDvyYwxybKlEuoDuQthz1gumSpvya0SRZnkGfn33LZoYqCupUDX3WhcsA1mm2PjXQcB6XZ4s7WNztNvj3Ckr7SQgn-nbqC_0I893dmDbcJ8mu7gXUQ7BApDQx9th_TBnOAKDXR0BfFMwET0dlI652F-ErdDxBDtkNQ1BPriXTOaaNM9dqCb4wF9N92EvTX0BaLFIYaP5KaFLuCny7wnf1bPv5822e7nevv0sMtMoXTMaq6gNhLKmkHaQYG6VqVppNCyBc3TFmUjzFJo1oARZVEaueSi1gmXpVaY35Ov59z0wb9jembV22Cw62BAN4ZKFYVUfFkk4_xsNN6F4LGtDt724I8VZ9XUVjW1VaW2qtRWsn-55I51j83VfKkn8dWZ70OEV7xy8NGaDk9hXKfUU-DlTMFXg3kDX-GQ_weJBamk</recordid><startdate>19800101</startdate><enddate>19800101</enddate><creator>MARUHAMA, YOSHISUKE</creator><creator>NAGASAKI, AKIO</creator><creator>KANAZAWA, YOSHIHIKO</creator><creator>HIRAKAWA, HIDENORI</creator><creator>GOTO, YOSHIO</creator><creator>NISHIYAMA, HIROCHIKA</creator><creator>KISHIMOTO, YOSHIMI</creator><creator>SHIMOYAMA, TAKASHI</creator><general>Tohoku University Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19800101</creationdate><title>Effects of a Glucoside-Hydrolase Inhibitor (Bay g 5421) on Serum Lipids, Lipoproteins and Bile Acids, Fecal Fat and Bacterial Flora, and Intestinal Gas Production in Hyperlipidemic Patients</title><author>MARUHAMA, YOSHISUKE ; NAGASAKI, AKIO ; KANAZAWA, YOSHIHIKO ; HIRAKAWA, HIDENORI ; GOTO, YOSHIO ; NISHIYAMA, HIROCHIKA ; KISHIMOTO, YOSHIMI ; SHIMOYAMA, TAKASHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c579t-b17abc4a6b0a0035e9b76cd4294fa911624d2c8290dac2656c4812b994f6697e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Acarbose</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>bile acids</topic><topic>Bile Acids and Salts - blood</topic><topic>Body Weight - drug effects</topic><topic>Drug Evaluation</topic><topic>Fats - analysis</topic><topic>fecal flora</topic><topic>Feces - analysis</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Gases</topic><topic>glucoside-hydrolase inhibitor</topic><topic>Humans</topic><topic>Hyperlipidemias - blood</topic><topic>Intestines - physiopathology</topic><topic>Lipids - blood</topic><topic>Lipoproteins - blood</topic><topic>Male</topic><topic>meteorism</topic><topic>Middle Aged</topic><topic>Oligosaccharides - pharmacology</topic><topic>serum lipoproteins</topic><topic>Trisaccharides - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MARUHAMA, YOSHISUKE</creatorcontrib><creatorcontrib>NAGASAKI, AKIO</creatorcontrib><creatorcontrib>KANAZAWA, YOSHIHIKO</creatorcontrib><creatorcontrib>HIRAKAWA, HIDENORI</creatorcontrib><creatorcontrib>GOTO, YOSHIO</creatorcontrib><creatorcontrib>NISHIYAMA, HIROCHIKA</creatorcontrib><creatorcontrib>KISHIMOTO, YOSHIMI</creatorcontrib><creatorcontrib>SHIMOYAMA, TAKASHI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Tohoku Journal of Experimental Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MARUHAMA, YOSHISUKE</au><au>NAGASAKI, AKIO</au><au>KANAZAWA, YOSHIHIKO</au><au>HIRAKAWA, HIDENORI</au><au>GOTO, YOSHIO</au><au>NISHIYAMA, HIROCHIKA</au><au>KISHIMOTO, YOSHIMI</au><au>SHIMOYAMA, TAKASHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a Glucoside-Hydrolase Inhibitor (Bay g 5421) on Serum Lipids, Lipoproteins and Bile Acids, Fecal Fat and Bacterial Flora, and Intestinal Gas Production in Hyperlipidemic Patients</atitle><jtitle>The Tohoku Journal of Experimental Medicine</jtitle><addtitle>Tohoku J. Exp. Med.</addtitle><date>1980-01-01</date><risdate>1980</risdate><volume>132</volume><issue>4</issue><spage>453</spage><epage>462</epage><pages>453-462</pages><issn>0040-8727</issn><eissn>1349-3329</eissn><abstract>Significant decrease in serum very low density lipoproteins and low density lipoproteins was observed after Bay g 5421 trial (300mg/day for 6 weeks) in 14 hyperlipidemic patients. Although no significant changes were demonstrated in serum fractions of bile acids, the alteration in the patterns of fecal bacterial flora including the increase in obligate anaerobes was observed after the trial and this was accompanied by the increase in fecal fat excretion. Thus, the possible change in the intestinal bile acid metabolism with the altered flora may lead to an increased catabolism of cholesterol and to the reduction of serum low density lipoproteins. The meteorism developed in several patients but its etiology was shown to be independent of the patterns of the pre-trial bacterial flora and diet composition.</abstract><cop>Japan</cop><pub>Tohoku University Medical Press</pub><pmid>7256727</pmid><doi>10.1620/tjem.132.453</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0040-8727 |
| ispartof | The Tohoku Journal of Experimental Medicine, 1980, Vol.132(4), pp.453-462 |
| issn | 0040-8727 1349-3329 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75547185 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acarbose Adolescent Adult Aged bile acids Bile Acids and Salts - blood Body Weight - drug effects Drug Evaluation Fats - analysis fecal flora Feces - analysis Feces - microbiology Female Gases glucoside-hydrolase inhibitor Humans Hyperlipidemias - blood Intestines - physiopathology Lipids - blood Lipoproteins - blood Male meteorism Middle Aged Oligosaccharides - pharmacology serum lipoproteins Trisaccharides - pharmacology |
| title | Effects of a Glucoside-Hydrolase Inhibitor (Bay g 5421) on Serum Lipids, Lipoproteins and Bile Acids, Fecal Fat and Bacterial Flora, and Intestinal Gas Production in Hyperlipidemic Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T06%3A37%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20a%20Glucoside-Hydrolase%20Inhibitor%20(Bay%20g%205421)%20on%20Serum%20Lipids,%20Lipoproteins%20and%20Bile%20Acids,%20Fecal%20Fat%20and%20Bacterial%20Flora,%20and%20Intestinal%20Gas%20Production%20in%20Hyperlipidemic%20Patients&rft.jtitle=The%20Tohoku%20Journal%20of%20Experimental%20Medicine&rft.au=MARUHAMA,%20YOSHISUKE&rft.date=1980-01-01&rft.volume=132&rft.issue=4&rft.spage=453&rft.epage=462&rft.pages=453-462&rft.issn=0040-8727&rft.eissn=1349-3329&rft_id=info:doi/10.1620/tjem.132.453&rft_dat=%3Cproquest_cross%3E75547185%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75547185&rft_id=info:pmid/7256727&rfr_iscdi=true |