Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells
The cellular localization of peripheral-type benzodiazepine receptors (PBRs) was characterized in several human blood cell subpopulations including erythrocytes, platelets, monocytes and polymorphonuclear neutrophils (PMN), B, NK, T8 and T4-cells. Pharmacological properties of the PBR were establish...
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Veröffentlicht in: | Life sciences (1973) 1993, Vol.52 (1), p.107-118 |
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container_title | Life sciences (1973) |
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creator | Canat, Xavier Carayon, Pierre Bouaboula, Monsif Cahard, Dominique Shire, David Roque, Claude Le Fur, Gérard Casellas, Pierre |
description | The cellular localization of peripheral-type benzodiazepine receptors (PBRs) was characterized in several human blood cell subpopulations including erythrocytes, platelets, monocytes and polymorphonuclear neutrophils (PMN), B, NK, T8 and T4-cells. Pharmacological properties of the PBR were established by binding studies and PBR mRNA expression was measured by quantitative polymerase chain reaction based method. These data clearly indicate 1) the PBR is pharmacologically homogeneous in the various types of blood cells, 2) the rank order of PBR cell density is monocytes = PMN > lymphocytes ⪢ platelets > erythrocytes, 3) the PBR appears to be transcriptionally regulated since mRNA levels are roughly correlated with PBR density. |
doi_str_mv | 10.1016/0024-3205(93)90293-C |
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Pharmacological properties of the PBR were established by binding studies and PBR mRNA expression was measured by quantitative polymerase chain reaction based method. These data clearly indicate 1) the PBR is pharmacologically homogeneous in the various types of blood cells, 2) the rank order of PBR cell density is monocytes = PMN > lymphocytes ⪢ platelets > erythrocytes, 3) the PBR appears to be transcriptionally regulated since mRNA levels are roughly correlated with PBR density.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(93)90293-C</identifier><identifier>PMID: 8380214</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Antibodies, Monoclonal ; Base Sequence ; Biological and medical sciences ; Blood Cells - metabolism ; Blotting, Southern ; Carbon Radioisotopes ; Cell Line ; Fundamental and applied biological sciences. Psychology ; Hematopoietic Stem Cells - metabolism ; Humans ; Isoquinolines - metabolism ; Molecular Sequence Data ; Polymerase Chain Reaction ; Radioligand Assay ; Receptors, GABA-A - metabolism ; RNA, Messenger - analysis ; Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><ispartof>Life sciences (1973), 1993, Vol.52 (1), p.107-118</ispartof><rights>1992</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-c36193cd9e453335708eb3e277fad3de636666300c1e64f6afb193b12f2e07fd3</citedby><cites>FETCH-LOGICAL-c367t-c36193cd9e453335708eb3e277fad3de636666300c1e64f6afb193b12f2e07fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/002432059390293C$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4481371$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8380214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Canat, Xavier</creatorcontrib><creatorcontrib>Carayon, Pierre</creatorcontrib><creatorcontrib>Bouaboula, Monsif</creatorcontrib><creatorcontrib>Cahard, Dominique</creatorcontrib><creatorcontrib>Shire, David</creatorcontrib><creatorcontrib>Roque, Claude</creatorcontrib><creatorcontrib>Le Fur, Gérard</creatorcontrib><creatorcontrib>Casellas, Pierre</creatorcontrib><title>Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>The cellular localization of peripheral-type benzodiazepine receptors (PBRs) was characterized in several human blood cell subpopulations including erythrocytes, platelets, monocytes and polymorphonuclear neutrophils (PMN), B, NK, T8 and T4-cells. Pharmacological properties of the PBR were established by binding studies and PBR mRNA expression was measured by quantitative polymerase chain reaction based method. These data clearly indicate 1) the PBR is pharmacologically homogeneous in the various types of blood cells, 2) the rank order of PBR cell density is monocytes = PMN > lymphocytes ⪢ platelets > erythrocytes, 3) the PBR appears to be transcriptionally regulated since mRNA levels are roughly correlated with PBR density.</description><subject>Antibodies, Monoclonal</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blood Cells - metabolism</subject><subject>Blotting, Southern</subject><subject>Carbon Radioisotopes</subject><subject>Cell Line</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hematopoietic Stem Cells - metabolism</subject><subject>Humans</subject><subject>Isoquinolines - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Polymerase Chain Reaction</subject><subject>Radioligand Assay</subject><subject>Receptors, GABA-A - metabolism</subject><subject>RNA, Messenger - analysis</subject><subject>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFv1TAMgCMEGm-DfwBSD2iCQ0dSt017QUKPAZMmcYFzlCaO5qltSpIibb9-6d7TO5KDY8mfLftj7J3gV4KL9jPnVV1CxZuPPXzqedVDuX_BdqKTfclbEC_Z7oS8Zucx3nPOm0bCGTvroOOVqHfs_hvFFGhYE_m5WIJ3NGKhZ7vlC4ZEGAvvipzScodBj2V6WLAYcH70lvQjLjRjEdDgknzI7FzcrZPOESe_eMJEpjA4jvENe-X0GPHt8b9gf75f_97_LG9__bjZf70tDbQybVH0YGyPdQMAjeQdDoCVlE5bsNhCmx9wbgS2tWu1GzI_iMpVyKWzcMEuD3PzBX9XjElNFLcN9Ix-jUo2zfPkDNYH0AQfY0CnlkCTDg9KcLUpVps_tflTPahnxWqf294f56_DhPbUdHSa6x-OdR2NHl3Qs6F4wuq6EyBFxr4cMMwu_hEGFQ3hbNBStpmU9fT_PZ4AyOeZkA</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Canat, Xavier</creator><creator>Carayon, Pierre</creator><creator>Bouaboula, Monsif</creator><creator>Cahard, Dominique</creator><creator>Shire, David</creator><creator>Roque, Claude</creator><creator>Le Fur, Gérard</creator><creator>Casellas, Pierre</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells</title><author>Canat, Xavier ; Carayon, Pierre ; Bouaboula, Monsif ; Cahard, Dominique ; Shire, David ; Roque, Claude ; Le Fur, Gérard ; Casellas, Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-c36193cd9e453335708eb3e277fad3de636666300c1e64f6afb193b12f2e07fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Antibodies, Monoclonal</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blood Cells - metabolism</topic><topic>Blotting, Southern</topic><topic>Carbon Radioisotopes</topic><topic>Cell Line</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hematopoietic Stem Cells - metabolism</topic><topic>Humans</topic><topic>Isoquinolines - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Polymerase Chain Reaction</topic><topic>Radioligand Assay</topic><topic>Receptors, GABA-A - metabolism</topic><topic>RNA, Messenger - analysis</topic><topic>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Canat, Xavier</creatorcontrib><creatorcontrib>Carayon, Pierre</creatorcontrib><creatorcontrib>Bouaboula, Monsif</creatorcontrib><creatorcontrib>Cahard, Dominique</creatorcontrib><creatorcontrib>Shire, David</creatorcontrib><creatorcontrib>Roque, Claude</creatorcontrib><creatorcontrib>Le Fur, Gérard</creatorcontrib><creatorcontrib>Casellas, Pierre</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Canat, Xavier</au><au>Carayon, Pierre</au><au>Bouaboula, Monsif</au><au>Cahard, Dominique</au><au>Shire, David</au><au>Roque, Claude</au><au>Le Fur, Gérard</au><au>Casellas, Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1993</date><risdate>1993</risdate><volume>52</volume><issue>1</issue><spage>107</spage><epage>118</epage><pages>107-118</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>The cellular localization of peripheral-type benzodiazepine receptors (PBRs) was characterized in several human blood cell subpopulations including erythrocytes, platelets, monocytes and polymorphonuclear neutrophils (PMN), B, NK, T8 and T4-cells. 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subjects | Antibodies, Monoclonal Base Sequence Biological and medical sciences Blood Cells - metabolism Blotting, Southern Carbon Radioisotopes Cell Line Fundamental and applied biological sciences. Psychology Hematopoietic Stem Cells - metabolism Humans Isoquinolines - metabolism Molecular Sequence Data Polymerase Chain Reaction Radioligand Assay Receptors, GABA-A - metabolism RNA, Messenger - analysis Vertebrates: blood, hematopoietic organs, reticuloendothelial system |
title | Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells |
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