Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells

The cellular localization of peripheral-type benzodiazepine receptors (PBRs) was characterized in several human blood cell subpopulations including erythrocytes, platelets, monocytes and polymorphonuclear neutrophils (PMN), B, NK, T8 and T4-cells. Pharmacological properties of the PBR were establish...

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Veröffentlicht in:Life sciences (1973) 1993, Vol.52 (1), p.107-118
Hauptverfasser: Canat, Xavier, Carayon, Pierre, Bouaboula, Monsif, Cahard, Dominique, Shire, David, Roque, Claude, Le Fur, Gérard, Casellas, Pierre
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container_end_page 118
container_issue 1
container_start_page 107
container_title Life sciences (1973)
container_volume 52
creator Canat, Xavier
Carayon, Pierre
Bouaboula, Monsif
Cahard, Dominique
Shire, David
Roque, Claude
Le Fur, Gérard
Casellas, Pierre
description The cellular localization of peripheral-type benzodiazepine receptors (PBRs) was characterized in several human blood cell subpopulations including erythrocytes, platelets, monocytes and polymorphonuclear neutrophils (PMN), B, NK, T8 and T4-cells. Pharmacological properties of the PBR were established by binding studies and PBR mRNA expression was measured by quantitative polymerase chain reaction based method. These data clearly indicate 1) the PBR is pharmacologically homogeneous in the various types of blood cells, 2) the rank order of PBR cell density is monocytes = PMN > lymphocytes ⪢ platelets > erythrocytes, 3) the PBR appears to be transcriptionally regulated since mRNA levels are roughly correlated with PBR density.
doi_str_mv 10.1016/0024-3205(93)90293-C
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Antibodies, Monoclonal
Base Sequence
Biological and medical sciences
Blood Cells - metabolism
Blotting, Southern
Carbon Radioisotopes
Cell Line
Fundamental and applied biological sciences. Psychology
Hematopoietic Stem Cells - metabolism
Humans
Isoquinolines - metabolism
Molecular Sequence Data
Polymerase Chain Reaction
Radioligand Assay
Receptors, GABA-A - metabolism
RNA, Messenger - analysis
Vertebrates: blood, hematopoietic organs, reticuloendothelial system
title Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells
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