Effect of dermorphin on behavior and hippocampal electrical activity in rabbits
Dermorphin, a naturally occurring heptapeptide that selectively binds to μ-opioid receptors, was injected intravenously 0.4 mg/kg in male rabbits. Eight days before injection the spontaneous behavior of the animals was observed in a neutral environment in the absence of external stimuli. At the same...
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| Veröffentlicht in: | Life sciences (1973) 1993, Vol.52 (3), p.323-328 |
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| container_title | Life sciences (1973) |
| container_volume | 52 |
| creator | Fontani, G. Vergnani, L. Salvadori, S. Voglino, N. Aloisi, A.M. Portaluppi, F. degli Uberti, E.C. |
| description | Dermorphin, a naturally occurring heptapeptide that selectively binds to μ-opioid receptors, was injected intravenously 0.4 mg/kg in male rabbits. Eight days before injection the spontaneous behavior of the animals was observed in a neutral environment in the absence of external stimuli. At the same time, hippocampal EEG was recorded by telemetry. After dermorphin injection, the same experimental procedure was repeated. Behavior showed a strong increase in quiet immobility and a concomitant reduction in voluntary activities as compared to control periods. Treatment did not affect either the pattern or the frequency of hippocampal electrical activity. |
| doi_str_mv | 10.1016/0024-3205(93)90224-Q |
| format | Article |
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Eight days before injection the spontaneous behavior of the animals was observed in a neutral environment in the absence of external stimuli. At the same time, hippocampal EEG was recorded by telemetry. After dermorphin injection, the same experimental procedure was repeated. Behavior showed a strong increase in quiet immobility and a concomitant reduction in voluntary activities as compared to control periods. 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Eight days before injection the spontaneous behavior of the animals was observed in a neutral environment in the absence of external stimuli. At the same time, hippocampal EEG was recorded by telemetry. After dermorphin injection, the same experimental procedure was repeated. Behavior showed a strong increase in quiet immobility and a concomitant reduction in voluntary activities as compared to control periods. Treatment did not affect either the pattern or the frequency of hippocampal electrical activity.</description><subject>activity</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>behaviour</subject><subject>Biological and medical sciences</subject><subject>dermorphin</subject><subject>EEG</subject><subject>effects on</subject><subject>Electrophysiology</subject><subject>hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Oligopeptides - administration & dosage</subject><subject>Oligopeptides - pharmacology</subject><subject>opiates</subject><subject>Opioid Peptides</subject><subject>Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabbits</subject><subject>receptors</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVpSTZJ_0EDPpTSHtzoa2zrEihL0hYCIdCexVgfrIJtOZJ3If--2u6yx_ak0czzDsNDyAdGvzLKmhtKuawFp_BZiS-K8vJ7ekNWrGtVTRvB3pLVCTknFzk_U0oBWnFGzjqqREdhRR7vvHdmqaKvrEtjTPMmTFWcqt5tcBdiqnCy1SbMczQ4zjhUbih8CqaUaJawC8trVSIJ-z4s-Yq88zhk9_74XpLf93e_1j_qh8fvP9ffHmojG7HUfQdAPXbQNo4x9NJb1iIKyThXDBrlbNMqWzpWMo-tUbwHobDn5e6Wc3FJPh32zim-bF1e9BiyccOAk4vbrFsAKUHCf0HWSKBUigLKA2hSzDk5r-cURkyvmlG9F673NvXeplZC_xWun0rs-rh_24_OnkJHw2X-8TjHXJz5hJMJ-YRJAA7QFez2gLkibRdc0tkENxlnQyq-tY3h33f8AeUBm3k</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Fontani, G.</creator><creator>Vergnani, L.</creator><creator>Salvadori, S.</creator><creator>Voglino, N.</creator><creator>Aloisi, A.M.</creator><creator>Portaluppi, F.</creator><creator>degli Uberti, E.C.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Effect of dermorphin on behavior and hippocampal electrical activity in rabbits</title><author>Fontani, G. ; Vergnani, L. ; Salvadori, S. ; Voglino, N. ; Aloisi, A.M. ; Portaluppi, F. ; degli Uberti, E.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-b8550fa8576e11af4fd17aa3412291569ed679daa3d41fa7c92b539ab29387223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>activity</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - pharmacology</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>behaviour</topic><topic>Biological and medical sciences</topic><topic>dermorphin</topic><topic>EEG</topic><topic>effects on</topic><topic>Electrophysiology</topic><topic>hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. 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| subjects | activity Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacology Animals Behavior, Animal - drug effects behaviour Biological and medical sciences dermorphin EEG effects on Electrophysiology hippocampus Hippocampus - drug effects Hippocampus - physiology Injections, Intravenous Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Oligopeptides - administration & dosage Oligopeptides - pharmacology opiates Opioid Peptides Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Rabbits receptors |
| title | Effect of dermorphin on behavior and hippocampal electrical activity in rabbits |
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