Achievement of Therapeutic Concentrations of Cefuroxime in Early Preterm Gestations With Premature Rupture of the Membranes

OBJECTIVE:To determine whether therapeutic cefuroxime concentrations can be achieved in maternal plasma, amniotic fluid (AF), neonatal plasma, placenta, and membranes in women with premature rupture of the membranes (PROM) at 27-33 weeksʼ gestation METHODS:In an open nonrandomized, dose-response stu...

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Veröffentlicht in:	Obstetrics and gynecology (New York. 1953) 1993-02, Vol.81 (2), p.255-260
Hauptverfasser:	DE LEEUW, JAN W, ROUMEN, FRANS J. M. E, BOUCKAERT, PETER X. J. M, CREMERS, HARRY M. H. G, VREE, TOM B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amniotic Fluid - chemistry Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cefuroxime - administration & dosage Cefuroxime - pharmacokinetics Cefuroxime - therapeutic use Chorioamnionitis - prevention & control Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Female Fetal Membranes, Premature Rupture - drug therapy Humans Infant, Newborn Medical sciences Pharmacology. Drug treatments Pilot Projects Pregnancy Pregnancy Outcome Prospective Studies
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